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- Beta-Hydroxy_beta-methylbutyric_acid abstract "Beta-Hydroxy beta-methylbutyric acid β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β-methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. Its part in protein synthesis was discovered by Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement. It was discovered in pigs and small quantities can also be found in grapefruit, alfalfa, and catfish. As a supplement it is usually sold as the calcium salt calcium beta-hydroxy-beta-methylbutyrate.Research published in the Journal of Applied Physiology has shown that HMB may have an effect on increasing muscle weight and strength. A review in Nutrition & Metabolism provides an in depth and objective analysis of HMB research.The same study lists as HMB's proposed mechanisms of action the following: Increased sarcolemmal integrity via conversion to HMG-CoA Enhanced protein synthesis via the mTOR pathway Depression of protein degradation through inhibition of the ubiquitin pathwayThe human body produces about 0.2-0.4 grams per day. Standard doses in research studies have been 1.5 to 3.0 grams per day, usually divided into two doses. Toxicity at these doses is unlikely, as the no-observed-adverse-event-level (NOAEL) in rats is between 2.48 to 2.83 g/kg BW per day, roughly equivalent to 70 to 100 g/day in humans.".
- Beta-Hydroxy_beta-methylbutyric_acid iupacName "3-hydroxy-3-methylbutanoic acid".
- Beta-Hydroxy_beta-methylbutyric_acid thumbnail Hydroxymethylbutyric_acid.png?width=300.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageID "2570928".
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageLength "4343".
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageOutDegree "22".
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageRevisionID "671494352".
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Alfalfa.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Amino_acid.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Calcium_beta-hydroxy-beta-methylbutyrate.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Category:Bodybuilding_supplements.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Category:Dietary_supplements.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Category:Hydroxy_acids.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Catfish.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Essential_amino_acid.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Grapefruit.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink HMG-CoA.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Human_body.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Iowa_State_University.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Leucine.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Mechanism_of_action.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Mechanistic_target_of_rapamycin.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Metabolite.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink No-observed-adverse-effect_level.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Protein.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Proteolysis.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Salt_(chemistry).
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Sarcolemma.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLink Ubiquitin.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLinkText "''beta''-Hydroxy ''beta''-methylbutyric acid".
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLinkText "3-hydroxyisovaleric acid".
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLinkText "Beta-Hydroxy beta-methylbutyric acid".
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLinkText "HMB".
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageWikiLinkText "beta-Hydroxy beta-methylbutyric acid".
- Beta-Hydroxy_beta-methylbutyric_acid imagefile "Hydroxymethylbutyric acid.png".
- Beta-Hydroxy_beta-methylbutyric_acid imagesize "150".
- Beta-Hydroxy_beta-methylbutyric_acid iupacname "3".
- Beta-Hydroxy_beta-methylbutyric_acid name "β-Hydroxy β-methylbutyric acid".
- Beta-Hydroxy_beta-methylbutyric_acid othernames "3".
- Beta-Hydroxy_beta-methylbutyric_acid othernames "β-Hydroxyisovaleric acid".
- Beta-Hydroxy_beta-methylbutyric_acid verifiedfields "changed".
- Beta-Hydroxy_beta-methylbutyric_acid verifiedrevid "444517582".
- Beta-Hydroxy_beta-methylbutyric_acid watchedfields "changed".
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageUsesTemplate Template:Cascite.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageUsesTemplate Template:Chembox.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageUsesTemplate Template:Chembox_Hazards.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageUsesTemplate Template:Chembox_Identifiers.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageUsesTemplate Template:Chembox_Properties.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageUsesTemplate Template:Chemspidercite.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageUsesTemplate Template:Ebicite.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageUsesTemplate Template:Fdacite.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageUsesTemplate Template:Stdinchicite.
- Beta-Hydroxy_beta-methylbutyric_acid subject Category:Bodybuilding_supplements.
- Beta-Hydroxy_beta-methylbutyric_acid subject Category:Dietary_supplements.
- Beta-Hydroxy_beta-methylbutyric_acid subject Category:Hydroxy_acids.
- Beta-Hydroxy_beta-methylbutyric_acid hypernym Metabolite.
- Beta-Hydroxy_beta-methylbutyric_acid type ChemicalCompound.
- Beta-Hydroxy_beta-methylbutyric_acid type ChemicalSubstance.
- Beta-Hydroxy_beta-methylbutyric_acid type Alcohol.
- Beta-Hydroxy_beta-methylbutyric_acid type Dietetic.
- Beta-Hydroxy_beta-methylbutyric_acid type Redirect.
- Beta-Hydroxy_beta-methylbutyric_acid type ChemicalObject.
- Beta-Hydroxy_beta-methylbutyric_acid type Thing.
- Beta-Hydroxy_beta-methylbutyric_acid type Q11173.
- Beta-Hydroxy_beta-methylbutyric_acid comment "Beta-Hydroxy beta-methylbutyric acid β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β-methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. Its part in protein synthesis was discovered by Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement.".
- Beta-Hydroxy_beta-methylbutyric_acid label "Beta-Hydroxy beta-methylbutyric acid".
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Q223081.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Hydroxymetylbutyrát.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs 3-Hydroxy-3-methylbuttersäure.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs بتا-هیدروکسی_بتا-متیلبوتیریک_اسید.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Acido_3-idrossi-3-metilbutirrico.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs 3-ヒドロキシイソ吉草酸.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs 3-hydroxy-3-methylbutaanzuur.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Kwas_3-hydroksy-3-metylomasłowy.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Ácido_beta-hidroxi-beta-metilbutírico.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs m.07ns6d.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Beta-Hidroksi_beta-metilbutirna_kiselina.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Beta-Hidroksi_beta-metilbutirna_kiselina.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Q223081.
- Beta-Hydroxy_beta-methylbutyric_acid wasDerivedFrom Beta-Hydroxy_beta-methylbutyric_acid?oldid=671494352.
- Beta-Hydroxy_beta-methylbutyric_acid depiction Hydroxymethylbutyric_acid.png.
- Beta-Hydroxy_beta-methylbutyric_acid isPrimaryTopicOf Beta-Hydroxy_beta-methylbutyric_acid.
- Beta-Hydroxy_beta-methylbutyric_acid name "β-Hydroxy β-methylbutyric acid".