Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Bcr-Abl_tyrosine-kinase_inhibitor> ?p ?o }
- Bcr-Abl_tyrosine-kinase_inhibitor abstract "Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML). More than 90% of CML cases are caused by a chromosomal abnormality that results in the formation of a so-called Philadelphia chromosome. This abnormality was discovered by Janet Rowley in 1972 and is a consequence of fusion between the Abelson (Abl) tyrosine kinase gene at chromosome 9 and the break point cluster (Bcr) gene at chromosome 22, resulting in a chimeric oncogene (Bcr-Abl) and a constitutively active Bcr-Abl tyrosine kinase that has been implicated in the pathogenesis of CML. Compounds have been developed to selectively inhibit the tyrosine kinase.Before the 2001 U.S. Food and Drug Administration (FDA) approval of imatinib, no drugs were available to alter the natural progression of CML. Only cytotoxic drugs such as busulfan, hydroxyurea or interferon-alpha (rIFN-α) were utilized. Even though the first Bcr-Abl TK inhibitor was named “the magic bullet” to cure cancer by TIME magazine, a second generation of Bcr-Abl TKI was subsequently developed to combat the initial resistance that emerged.New forms of resistance can arise as: missense mutations within the Abl kinase domain, over-expression of Bcr-Abl, increased production of transmembrane plasma proteins, or the constitutive activation of downstream signaling molecules such as Src-family kinases.".
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageExternalLink explore.do?structureId=2GQG.
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- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageRevisionID "706836942".
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink 2-Butyne.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink ABL_(gene).
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink ARIAD_Pharmaceuticals.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Acetylene.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Adenosine_triphosphate.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Adverse_effect.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Amino_acid.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Aminothiazole.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Aniline.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Apoptosis.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Arene_substitution_pattern.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Aryl.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Aspartic_acid.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink BCR_(gene).
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Backbone_chain.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Bcr-Abl_tyrosine-kinase_inhibitor.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Blastic_phase_chronic_myelogenous_leukemia.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Blood_proteins.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Bosutinib.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Bromine.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Busulfan.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink C-terminus.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Carboxamide.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Carboxylic_acid.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Category:Drug_discovery.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Category:Leukemia.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Category:Medical_treatments.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Category:Non-receptor_tyrosine_kinase_inhibitors.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Cell_growth.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Chemical_structure.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Chemotherapy.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Chlorine.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Chromosome_22_(human).
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Chromosome_9_(human).
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Chronic_myelogenous_leukemia.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Chronic_phase_chronic_myelogenous_leukemia.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Chronology.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Compliance_(medicine).
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Cyclopentane.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Cyclopropane.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Cytosine.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Cytotoxicity.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Dasatinib.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Digital_screening.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Docking_(molecular).
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Drug_design.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Drug_intolerance.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Drug_resistance.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Ethynyl_radical.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Fluorine.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Food_and_Drug_Administration.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Fusion_gene.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Gene.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Gene_duplication.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Genetic_code.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Glutamic_acid.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Glycine.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Helix.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Hematology.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink High-throughput_screening.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Histidine.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Human_genome.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Hydrochloride.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Hydrogen_bond.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Hydrophile.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Hydrophobe.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Hydroxycarbamide.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Hydroxyl.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Hypothesis.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink IC50.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Imatinib.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Imidazole.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Immortalised_cell_line.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Immunosuppressive_drug.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink In_vitro.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Interferon.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Isoleucine.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Janet_Rowley.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Lead_compound.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Leucine.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Lipophilicity.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Metabolic_pathway.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Methionine.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Methoxy.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Missense_mutation.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Molar_concentration.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Molecular_cloning.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Molecule.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Nilotinib.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Nitrile.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Novartis.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Nucleic_acid_sequence.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Nucleotide.
- Bcr-Abl_tyrosine-kinase_inhibitor wikiPageWikiLink Oncogene.