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- Bcl-xL abstract "B-cell lymphoma-extra large (Bcl-xl, or BCL2-like 1 isoform 1) is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of proteins, and acts as a pro-survival protein by preventing the release of mitochondrial contents such as cytochrome c, which would lead to caspase activation. It is a well-established concept in the field of apoptosis that relative amounts of pro- and anti-survival Bcl-2 family of proteins define whether the cell will undergo cell death: if more Bcl-xL is present, then pores are non-permeable to pro-apoptotic molecules and the cell survives. However, if Bax and Bak become activated, and Bcl-xL is sequestered away by gatekeeper BH3-only factors (e.g. Bim), causing a pore to form, cytochrome c is released leading to initiation of caspase cascade leading to apoptotic events.Bcl-xL functions at the level of intrinsic apoptotic pathway, while extrinsic pathway (Fas/TNF death receptors) directly leads to caspase activation. There is a link between extrinsic and intrinsic pathways, via caspase-mediated cleavage of BID, which functions to activate pore formation at the mitochondria.".
- Bcl-xL thumbnail Bcl-xl.jpg?width=300.
- Bcl-xL wikiPageID "10029222".
- Bcl-xL wikiPageLength "2753".
- Bcl-xL wikiPageOutDegree "25".
- Bcl-xL wikiPageRevisionID "654380872".
- Bcl-xL wikiPageWikiLink Apoptosis.
- Bcl-xL wikiPageWikiLink BCL2-like_1_(gene).
- Bcl-xL wikiPageWikiLink BCL2L11.
- Bcl-xL wikiPageWikiLink BCL2L2.
- Bcl-xL wikiPageWikiLink BH3_interacting-domain_death_agonist.
- Bcl-xL wikiPageWikiLink Bcl-2.
- Bcl-xL wikiPageWikiLink Bcl-2-associated_X_protein.
- Bcl-xL wikiPageWikiLink Bcl-2_family.
- Bcl-xL wikiPageWikiLink Bcl-2_homologous_antagonist_killer.
- Bcl-xL wikiPageWikiLink Caspase.
- Bcl-xL wikiPageWikiLink Category:Cancer_research.
- Bcl-xL wikiPageWikiLink Category:Mitochondria.
- Bcl-xL wikiPageWikiLink Cytochrome_c.
- Bcl-xL wikiPageWikiLink Fas_receptor.
- Bcl-xL wikiPageWikiLink GATA1.
- Bcl-xL wikiPageWikiLink Janus_kinase_2.
- Bcl-xL wikiPageWikiLink Knockout_mouse.
- Bcl-xL wikiPageWikiLink MCL1.
- Bcl-xL wikiPageWikiLink Mitochondrion.
- Bcl-xL wikiPageWikiLink Polycythemia_vera.
- Bcl-xL wikiPageWikiLink Red_blood_cell.
- Bcl-xL wikiPageWikiLink STAT5.
- Bcl-xL wikiPageWikiLink Tumor_necrosis_factor_receptor.
- Bcl-xL wikiPageWikiLink File:Bcl-xl.jpg.
- Bcl-xL wikiPageWikiLink File:Signal_transduction_pathways.svg.
- Bcl-xL wikiPageWikiLinkText "BCL-XL".
- Bcl-xL wikiPageWikiLinkText "Bcl-XL".
- Bcl-xL wikiPageWikiLinkText "Bcl-xL".
- Bcl-xL wikiPageWikiLinkText "bcl-xL".
- Bcl-xL wikiPageUsesTemplate Template:Fas_apoptosis_signaling_pathway.
- Bcl-xL wikiPageUsesTemplate Template:Noref.
- Bcl-xL subject Category:Cancer_research.
- Bcl-xL subject Category:Mitochondria.
- Bcl-xL hypernym Molecule.
- Bcl-xL type ChemicalCompound.
- Bcl-xL type Redirect.
- Bcl-xL comment "B-cell lymphoma-extra large (Bcl-xl, or BCL2-like 1 isoform 1) is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of proteins, and acts as a pro-survival protein by preventing the release of mitochondrial contents such as cytochrome c, which would lead to caspase activation.".
- Bcl-xL label "Bcl-xL".
- Bcl-xL sameAs Q4875408.
- Bcl-xL sameAs m.02p_b21.
- Bcl-xL sameAs Q4875408.
- Bcl-xL wasDerivedFrom Bcl-xL?oldid=654380872.
- Bcl-xL depiction Bcl-xl.jpg.
- Bcl-xL isPrimaryTopicOf Bcl-xL.