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- Balanol abstract "Balanol is a fungal metabolite produced by the fungus Verticillium balanoides. It is a potent inhibitor of the serine/threonine kinases protein kinase A (PKA) and protein kinase C (PKC), binding in a similar manner with that of ATP. Balanol was discovered in 1993 in the search for novel inhibitors of PKC, a member of a family of serine/threonine kinases whose overactivation is associated with numerous human diseases of signal transduction including cancer. However, much of the research on balanol focuses on how chemical modifications of the molecular structure affect binding to PKA. Indeed, balanol, its chemically altered analogs, and their interactions with PKA in particular are used to illuminate the roles of selectivity and protein flexibility in the inhibition of kinases. For instance, the X-ray crystal structure of balanol in complex with PKA was used in order to confer selectivity and to improve pharmacological efficacy of inhibitors of the H. sapiens Akt (PKB), another serine/threonine protein kinase implicated in the proper functioning of many cellular processes.".
- Balanol casNumber "63590-19-2".
- Balanol drugbank "DB04098".
- Balanol iupacName "2-{[2,6-dihydroxy-4-({[(3S,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid".
- Balanol pubchem "5287736".
- Balanol thumbnail Balanol.svg?width=300.
- Balanol wikiPageID "31922827".
- Balanol wikiPageLength "12816".
- Balanol wikiPageOutDegree "19".
- Balanol wikiPageRevisionID "667247127".
- Balanol wikiPageWikiLink Adenosine_triphosphate.
- Balanol wikiPageWikiLink Azepane.
- Balanol wikiPageWikiLink Benzophenone.
- Balanol wikiPageWikiLink Benzoyl.
- Balanol wikiPageWikiLink CGMP-dependent_protein_kinase.
- Balanol wikiPageWikiLink Carbon-13_nuclear_magnetic_resonance.
- Balanol wikiPageWikiLink Category:Benzamides.
- Balanol wikiPageWikiLink Category:Phenols.
- Balanol wikiPageWikiLink Category:Protein_kinase_inhibitors.
- Balanol wikiPageWikiLink Infrared_spectroscopy.
- Balanol wikiPageWikiLink Metabolite.
- Balanol wikiPageWikiLink Protein_kinase_A.
- Balanol wikiPageWikiLink Protein_kinase_B.
- Balanol wikiPageWikiLink Protein_kinase_C.
- Balanol wikiPageWikiLink Proton_nuclear_magnetic_resonance.
- Balanol wikiPageWikiLink Staurosporine.
- Balanol wikiPageWikiLink Two-dimensional_nuclear_magnetic_resonance_spectroscopy.
- Balanol wikiPageWikiLink Verticillium.
- Balanol wikiPageWikiLinkText "(−)-balanol".
- Balanol wikiPageWikiLinkText "Balanol".
- Balanol c "28".
- Balanol casNumber "63590".
- Balanol chemspiderid "4450040".
- Balanol drugbank "DB04098".
- Balanol h "26".
- Balanol iupacName "2".
- Balanol iupharLigand "8142".
- Balanol molecularWeight "551.17".
- Balanol n "2".
- Balanol o "10".
- Balanol pubchem "5287736".
- Balanol verifiedfields "changed".
- Balanol verifiedrevid "470470622".
- Balanol width "300".
- Balanol wikiPageUsesTemplate Template:Chemspidercite.
- Balanol wikiPageUsesTemplate Template:Drugbankcite.
- Balanol wikiPageUsesTemplate Template:Drugbox.
- Balanol subject Category:Benzamides.
- Balanol subject Category:Phenols.
- Balanol subject Category:Protein_kinase_inhibitors.
- Balanol hypernym Metabolite.
- Balanol type ChemicalCompound.
- Balanol type ChemicalSubstance.
- Balanol type Drug.
- Balanol type Process.
- Balanol type ChemicalObject.
- Balanol type Thing.
- Balanol type Q8386.
- Balanol comment "Balanol is a fungal metabolite produced by the fungus Verticillium balanoides. It is a potent inhibitor of the serine/threonine kinases protein kinase A (PKA) and protein kinase C (PKC), binding in a similar manner with that of ATP. Balanol was discovered in 1993 in the search for novel inhibitors of PKC, a member of a family of serine/threonine kinases whose overactivation is associated with numerous human diseases of signal transduction including cancer.".
- Balanol label "Balanol".
- Balanol sameAs Q4850048.
- Balanol sameAs Balanol.
- Balanol sameAs m.0gvtp21.
- Balanol sameAs Q4850048.
- Balanol wasDerivedFrom Balanol?oldid=667247127.
- Balanol depiction Balanol.svg.
- Balanol isPrimaryTopicOf Balanol.