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- BU09059 abstract "BU09059 is a potent, selective, short-acting (non-\"inactivating\") antagonist of the κ-opioid receptor (KOR). It was derived from the irreversible (long-acting) KOR antagonist JDTic in search of an antagonist with a reversible profile of inactivation of the KOR that could be used with less concern to treat psychiatric disorders. In addition to its reversibility, BU09059 is much more selective for the KOR than JDTic, showing 15-fold and 616-fold preference for the KOR over the μ- and δ-opioid receptors (Ki = 1.72 nM, 26.5 nM, and 1060 nM, respectively).".
- BU09059 iupacName "[1-ethoxy-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-1-oxopropan-2-yl] (3R)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide".
- BU09059 thumbnail BU09059_structure.png?width=300.
- BU09059 wikiPageID "46402118".
- BU09059 wikiPageLength "3097".
- BU09059 wikiPageOutDegree "14".
- BU09059 wikiPageRevisionID "699727166".
- BU09059 wikiPageWikiLink AT-076.
- BU09059 wikiPageWikiLink samidorphan.
- BU09059 wikiPageWikiLink CERC-501.
- BU09059 wikiPageWikiLink Category:Kappa_antagonists.
- BU09059 wikiPageWikiLink Category:Opioid_antagonists.
- BU09059 wikiPageWikiLink Category:Synthetic_opioids.
- BU09059 wikiPageWikiLink Irreversible_antagonist.
- BU09059 wikiPageWikiLink JDTic.
- BU09059 wikiPageWikiLink Mental_disorder.
- BU09059 wikiPageWikiLink PF-4455242.
- BU09059 wikiPageWikiLink Receptor_antagonist.
- BU09059 wikiPageWikiLink Δ-opioid_receptor.
- BU09059 wikiPageWikiLink Κ-opioid_receptor.
- BU09059 wikiPageWikiLink Μ-opioid_receptor.
- BU09059 wikiPageWikiLinkText "BU09059".
- BU09059 c "28".
- BU09059 h "37".
- BU09059 iupacName "[1-ethoxy-3-[-4--3,4-dimethylpiperidin-1-yl]-1-oxopropan-2-yl] -7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide".
- BU09059 molecularWeight "495.609".
- BU09059 n "3".
- BU09059 o "5".
- BU09059 smiles "Oc3ccccC1CCNCCNCCCc2ccc4O".
- BU09059 wikiPageUsesTemplate Template:Drugbox.
- BU09059 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- BU09059 wikiPageUsesTemplate Template:Opioidergics.
- BU09059 wikiPageUsesTemplate Template:Reflist.
- BU09059 subject Category:Kappa_antagonists.
- BU09059 subject Category:Opioid_antagonists.
- BU09059 subject Category:Synthetic_opioids.
- BU09059 hypernym Antagonist.
- BU09059 type ChemicalSubstance.
- BU09059 type Drug.
- BU09059 type ChemicalObject.
- BU09059 type Thing.
- BU09059 type Q8386.
- BU09059 comment "BU09059 is a potent, selective, short-acting (non-\"inactivating\") antagonist of the κ-opioid receptor (KOR). It was derived from the irreversible (long-acting) KOR antagonist JDTic in search of an antagonist with a reversible profile of inactivation of the KOR that could be used with less concern to treat psychiatric disorders.".
- BU09059 label "BU09059".
- BU09059 sameAs Q19903625.
- BU09059 sameAs m.01347xql.
- BU09059 sameAs Q19903625.
- BU09059 wasDerivedFrom BU09059?oldid=699727166.
- BU09059 depiction BU09059_structure.png.
- BU09059 isPrimaryTopicOf BU09059.