Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/BMS-564,929> ?p ?o }
- BMS-564,929 abstract "BMS-564,929 is an investigational selective androgen receptor modulator, which is being developed by Bristol-Myers Squibb for treatment of the symptoms of age-related decline in androgen levels in men (\"andropause\"). These symptoms may include depression, loss of muscle mass and strength, reduction in libido and osteoporosis. Treatment with exogenous testosterone is effective in counteracting these symptoms but is associated with a range of side effects, the most serious of which is enlargement of the prostate gland, which can lead to benign prostatic hypertrophy and even prostate cancer. This means there is a clinical need for selective androgen receptor modulators, which produce anabolic effects in some tissues such as muscle and bone, but without stimulating androgen receptors in the prostate.BMS-564,929 is one such compound currently in early human clinical trials, which is an orally active, potent and selective agonist for androgen receptors (Ki 2.1nM, 20x functional selectivity for muscle tissue over prostate) and in studies on castrated rats it was shown to counteract decrease in muscle mass over time, and at higher doses even increased muscle mass, without significantly affecting prostate tissue. It does however vastly reduce luteinizing hormone levels, it being an astonishing 33x more suppressive compound than testosterone, which may be a problem in human clinical use.Selective androgen receptor modulators may also be used by athletes to assist in training and increase physical stamina and fitness, potentially producing effects similar to anabolic steroids but with significantly fewer side effects. For this reason, SARMs have already been banned by the World Anti-Doping Agency since January 2008 despite no drugs from this class yet being in clinical use, and blood tests for all known SARMs are currently being developed.".
- BMS-564,929 drugbank "DB07286".
- BMS-564,929 iupacName "(7R,7aS)-2-Chloro-4-(7-hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)-3-methylbenzonitrile".
- BMS-564,929 pubchem "9882972".
- BMS-564,929 thumbnail BMS-564,929.svg?width=300.
- BMS-564,929 wikiPageExternalLink explore.cgi?pdbId=2NW4.
- BMS-564,929 wikiPageID "19943267".
- BMS-564,929 wikiPageLength "7082".
- BMS-564,929 wikiPageOutDegree "29".
- BMS-564,929 wikiPageRevisionID "698228757".
- BMS-564,929 wikiPageWikiLink Anabolic_steroid.
- BMS-564,929 wikiPageWikiLink Anabolism.
- BMS-564,929 wikiPageWikiLink Andropause.
- BMS-564,929 wikiPageWikiLink Benign_prostatic_hyperplasia.
- BMS-564,929 wikiPageWikiLink Bristol-Myers_Squibb.
- BMS-564,929 wikiPageWikiLink Category:Alcohols.
- BMS-564,929 wikiPageWikiLink Category:Bristol-Myers_Squibb.
- BMS-564,929 wikiPageWikiLink Category:Chloroarenes.
- BMS-564,929 wikiPageWikiLink Category:Hormonal_agents.
- BMS-564,929 wikiPageWikiLink Category:Imides.
- BMS-564,929 wikiPageWikiLink Category:Lactams.
- BMS-564,929 wikiPageWikiLink Category:Nitriles.
- BMS-564,929 wikiPageWikiLink Category:Pyrroloimidazoles.
- BMS-564,929 wikiPageWikiLink Category:Ureas.
- BMS-564,929 wikiPageWikiLink Depression_(mood).
- BMS-564,929 wikiPageWikiLink Dissociation_constant.
- BMS-564,929 wikiPageWikiLink Functional_selectivity.
- BMS-564,929 wikiPageWikiLink Libido.
- BMS-564,929 wikiPageWikiLink Luteinizing_hormone.
- BMS-564,929 wikiPageWikiLink Muscle.
- BMS-564,929 wikiPageWikiLink Osteoporosis.
- BMS-564,929 wikiPageWikiLink Physical_strength.
- BMS-564,929 wikiPageWikiLink Prostate.
- BMS-564,929 wikiPageWikiLink Prostate_cancer.
- BMS-564,929 wikiPageWikiLink Protein_Data_Bank.
- BMS-564,929 wikiPageWikiLink Selective_androgen_receptor_modulator.
- BMS-564,929 wikiPageWikiLink Testosterone.
- BMS-564,929 wikiPageWikiLink World_Anti-Doping_Agency.
- BMS-564,929 wikiPageWikiLink Category:Selective_androgen_receptor_modulators.
- BMS-564,929 wikiPageWikiLinkText "BMS-564,929".
- BMS-564,929 c "14".
- BMS-564,929 chemspiderid "8058647".
- BMS-564,929 cl "1".
- BMS-564,929 drugbank "DB07286".
- BMS-564,929 h "12".
- BMS-564,929 inchi "1".
- BMS-564,929 inchikey "KEJORAMIZFOODM-PWSUYJOCBN".
- BMS-564,929 iupacName "-2".
- BMS-564,929 legalStatus "Investigational new drug".
- BMS-564,929 molecularWeight "305.716".
- BMS-564,929 n "3".
- BMS-564,929 o "3".
- BMS-564,929 pubchem "9882972".
- BMS-564,929 smiles "N#Cc3cccNCC2N1CCC2O".
- BMS-564,929 stdinchi "1".
- BMS-564,929 stdinchikey "KEJORAMIZFOODM-PWSUYJOCSA-N".
- BMS-564,929 verifiedfields "changed".
- BMS-564,929 verifiedrevid "424678818".
- BMS-564,929 wikiPageUsesTemplate Template:Androgenics.
- BMS-564,929 wikiPageUsesTemplate Template:Chemspidercite.
- BMS-564,929 wikiPageUsesTemplate Template:Drugbankcite.
- BMS-564,929 wikiPageUsesTemplate Template:Drugbox.
- BMS-564,929 wikiPageUsesTemplate Template:Reflist.
- BMS-564,929 wikiPageUsesTemplate Template:Stdinchicite.
- BMS-564,929 subject Category:Alcohols.
- BMS-564,929 subject Category:Bristol-Myers_Squibb.
- BMS-564,929 subject Category:Chloroarenes.
- BMS-564,929 subject Category:Hormonal_agents.
- BMS-564,929 subject Category:Imides.
- BMS-564,929 subject Category:Lactams.
- BMS-564,929 subject Category:Nitriles.
- BMS-564,929 subject Category:Pyrroloimidazoles.
- BMS-564,929 subject Category:Ureas.
- BMS-564,929 subject Category:Selective_androgen_receptor_modulators.
- BMS-564,929 hypernym Modulator.
- BMS-564,929 type Agent.
- BMS-564,929 type ChemicalSubstance.
- BMS-564,929 type Company.
- BMS-564,929 type Drug.
- BMS-564,929 type Group.
- BMS-564,929 type Agent.
- BMS-564,929 type Alcohol.
- BMS-564,929 type Amide.
- BMS-564,929 type Chemical.
- BMS-564,929 type Company.
- BMS-564,929 type Group.
- BMS-564,929 type Heterocycle.
- BMS-564,929 type Imide.
- BMS-564,929 type Lactam.
- BMS-564,929 type Nitrile.
- BMS-564,929 type Organohalide.
- BMS-564,929 type Preparation.
- BMS-564,929 type Organohalide.
- BMS-564,929 type ChemicalObject.
- BMS-564,929 type Thing.
- BMS-564,929 type Q8386.
- BMS-564,929 comment "BMS-564,929 is an investigational selective androgen receptor modulator, which is being developed by Bristol-Myers Squibb for treatment of the symptoms of age-related decline in androgen levels in men (\"andropause\"). These symptoms may include depression, loss of muscle mass and strength, reduction in libido and osteoporosis.".
- BMS-564,929 label "BMS-564,929".
- BMS-564,929 sameAs Q4836003.
- BMS-564,929 sameAs m.04y7b6j.