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- BEN_domain abstract "In molecular biology, the BEN domain is a protein domain which is found in diverse proteins including: SMAR1 (Scaffold/Matrix attachment region-binding protein 1; also known as BANP), a tumour-suppressor MAR-binding protein that down-regulates Cyclin D1 expression by recruiting HDAC1-mSin3A co-repressor complex at Cyclin D1 promoter locus; SMAR1 is the target of prostaglandin A2 (PGA2) induced growth arrest. NACC1, a novel member of the POZ/BTB (Pox virus and Zinc finger/Bric-a-bracTramtrack Broad complex), but which varies from other proteins of this class in that it lacks the characteristic DNA-binding motif. Mod(mdg4) isoform C, the modifier of the mdg4 locus in Drosophila melanogaster (Fruit fly), where mdg4 encodes chromatin proteins which are involved in position effect variegation, establishment of chromatin boundaries, nerve path finding, meiotic chromosome pairing and apoptosis. Trans-splicing of Mod(mdg4) produces at least 26 transcripts. E5R protein from Chordopoxvirus virosomes, which is found in cytoplasmic sites of viral DNA replication.Several proteins of polydnaviruses.The BEN domain is predicted to function as an adaptor for the higher-order structuring of chromatin, and recruitment of chromatin modifying factors in transcriptional regulation. It has been suggested to mediate protein-DNA and protein-protein interactions during chromatin organisation and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role in the organisation of viral DNA during replication or transcription. They are generally linked to other globular domains with functions related to transcriptional regulation and chromatin structure, such as BTB, C4DM, and C2H2 fingers.This domain is predicted to form an all-alpha fold with four conserved helices. Its conservation pattern revealed several conserved residues, most of which have hydrophobic side-chains and are likely to stabilise the fold through helix-helix packing.".
- BEN_domain symbol "BEN".
- BEN_domain wikiPageID "32160483".
- BEN_domain wikiPageLength "5112".
- BEN_domain wikiPageOutDegree "37".
- BEN_domain wikiPageRevisionID "694593967".
- BEN_domain wikiPageWikiLink Apoptosis.
- BEN_domain wikiPageWikiLink BANP.
- BEN_domain wikiPageWikiLink BTBD14B.
- BEN_domain wikiPageWikiLink Category:Protein_domains.
- BEN_domain wikiPageWikiLink Chromatin.
- BEN_domain wikiPageWikiLink Chromosome.
- BEN_domain wikiPageWikiLink Conserved_sequence.
- BEN_domain wikiPageWikiLink Cytoplasm.
- BEN_domain wikiPageWikiLink DNA_replication.
- BEN_domain wikiPageWikiLink Drosophila.
- BEN_domain wikiPageWikiLink Finger.
- BEN_domain wikiPageWikiLink Gene_expression.
- BEN_domain wikiPageWikiLink Hydrophobe.
- BEN_domain wikiPageWikiLink Locus_(genetics).
- BEN_domain wikiPageWikiLink Multiprotein_complex.
- BEN_domain wikiPageWikiLink Nerve.
- BEN_domain wikiPageWikiLink Prostaglandin.
- BEN_domain wikiPageWikiLink Protein.
- BEN_domain wikiPageWikiLink Protein_domain.
- BEN_domain wikiPageWikiLink Protein_folding.
- BEN_domain wikiPageWikiLink Protein–protein_interaction.
- BEN_domain wikiPageWikiLink Regulation.
- BEN_domain wikiPageWikiLink Side_chain.
- BEN_domain wikiPageWikiLink Structural_motif.
- BEN_domain wikiPageWikiLink Trans-splicing.
- BEN_domain wikiPageWikiLink Transcription_(genetics).
- BEN_domain wikiPageWikiLink Transcriptional_regulation.
- BEN_domain wikiPageWikiLink Virus.
- BEN_domain wikiPageWikiLink Zinc.
- BEN_domain interpro "IPR018379".
- BEN_domain name "BEN".
- BEN_domain pfam "PF10523".
- BEN_domain symbol "BEN".
- BEN_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- BEN_domain wikiPageUsesTemplate Template:InterPro_content.
- BEN_domain wikiPageUsesTemplate Template:Orphan.
- BEN_domain wikiPageUsesTemplate Template:Reflist.
- BEN_domain subject Category:Protein_domains.
- BEN_domain hypernym Domain.
- BEN_domain type Biomolecule.
- BEN_domain type Protein.
- BEN_domain type Domain.
- BEN_domain type Thing.
- BEN_domain type Q206229.
- BEN_domain type Q8054.
- BEN_domain comment "In molecular biology, the BEN domain is a protein domain which is found in diverse proteins including: SMAR1 (Scaffold/Matrix attachment region-binding protein 1; also known as BANP), a tumour-suppressor MAR-binding protein that down-regulates Cyclin D1 expression by recruiting HDAC1-mSin3A co-repressor complex at Cyclin D1 promoter locus; SMAR1 is the target of prostaglandin A2 (PGA2) induced growth arrest.".
- BEN_domain label "BEN domain".
- BEN_domain sameAs Q4835439.
- BEN_domain sameAs m.0gx0yj7.
- BEN_domain sameAs Q4835439.
- BEN_domain wasDerivedFrom BEN_domain?oldid=694593967.
- BEN_domain isPrimaryTopicOf BEN_domain.