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- BAG_domain abstract "In molecular biology, BAG domains are protein domains found in proteins which are modulators of chaperone activity, they bind to HSP70/HSC70 proteins and promote substrate release. The proteins have anti-apoptotic activity and increase the anti-cell death function of BCL-2 induced by various stimuli. BAG-1 binds to the serine/threonine kinase Raf-1 or Hsc70/Hsp70 in a mutually exclusive interaction. BAG-1 promotes cell growth by binding to and stimulating Raf-1 activity. The binding of Hsp70 to BAG-1 diminishes Raf-1 signalling and inhibits subsequent events, such as DNA synthesis, as well as arrests the cell cycle. BAG-1 has been suggested to function as a molecular switch that encourages cells to proliferate in normal conditions but become quiescent under a stressful environment .BAG-family proteins contain a single BAG domain, except for human BAG-5 which has four BAG repeats. The BAG domain is a conserved region located at the C terminus of the BAG-family proteins that binds the ATPase domain of Hsc70/Hsp70. The BAG domain is evolutionarily conserved, and BAG domain containing proteins have been described and/or proven in a variety of organisms including Mus musculus (Mouse), Xenopus spp., Drosophila spp., Bombyx mori (Silk moth), Caenorhabditis elegans, Saccharomyces cerevisiae (Baker's yeast), Schizosaccharomyces pombe (Fission yeast), and Arabidopsis thaliana (Mouse-ear cress).The BAG domain has 110-124 amino acids and is composed of three anti-parallel alpha-helices, each approximately 30-40 amino acids in length. The first and second helices interact with the serine/threonine kinase Raf-1 and the second and third helices are the sites of the BAG domain interaction with the ATPase domain of Hsc70/Hsp70. Binding of the BAG domain to the ATPase domain is mediated by both electrostatic and hydrophobic interactions in BAG-1 and is energy requiring.".
- BAG_domain symbol "BAG".
- BAG_domain thumbnail PDB_1hx1_EBI.jpg?width=300.
- BAG_domain wikiPageID "32158798".
- BAG_domain wikiPageLength "3106".
- BAG_domain wikiPageOutDegree "39".
- BAG_domain wikiPageRevisionID "590729325".
- BAG_domain wikiPageWikiLink ATPase.
- BAG_domain wikiPageWikiLink Alpha_helix.
- BAG_domain wikiPageWikiLink Amino_acid.
- BAG_domain wikiPageWikiLink Apoptosis.
- BAG_domain wikiPageWikiLink Arabidopsis_thaliana.
- BAG_domain wikiPageWikiLink BAG1.
- BAG_domain wikiPageWikiLink BAG5.
- BAG_domain wikiPageWikiLink Bcl-2.
- BAG_domain wikiPageWikiLink Bombyx_mori.
- BAG_domain wikiPageWikiLink C-Raf.
- BAG_domain wikiPageWikiLink Caenorhabditis_elegans.
- BAG_domain wikiPageWikiLink Category:Protein_families.
- BAG_domain wikiPageWikiLink Cell_(biology).
- BAG_domain wikiPageWikiLink Cell_cycle.
- BAG_domain wikiPageWikiLink Cell_growth.
- BAG_domain wikiPageWikiLink Cell_signaling.
- BAG_domain wikiPageWikiLink Chaperone_(protein).
- BAG_domain wikiPageWikiLink Conserved_sequence.
- BAG_domain wikiPageWikiLink Drosophila.
- BAG_domain wikiPageWikiLink Electrostatics.
- BAG_domain wikiPageWikiLink Energy.
- BAG_domain wikiPageWikiLink Evolution.
- BAG_domain wikiPageWikiLink G0_phase.
- BAG_domain wikiPageWikiLink Homo_sapiens.
- BAG_domain wikiPageWikiLink Hsp70.
- BAG_domain wikiPageWikiLink Hydrophobe.
- BAG_domain wikiPageWikiLink Kinase.
- BAG_domain wikiPageWikiLink Molecular_binding.
- BAG_domain wikiPageWikiLink Organism.
- BAG_domain wikiPageWikiLink Protein_domain.
- BAG_domain wikiPageWikiLink Protein–protein_interaction.
- BAG_domain wikiPageWikiLink Saccharomyces_cerevisiae.
- BAG_domain wikiPageWikiLink Schizosaccharomyces_pombe.
- BAG_domain wikiPageWikiLink threonine-specific_protein_kinase.
- BAG_domain wikiPageWikiLink Substrate_(chemistry).
- BAG_domain wikiPageWikiLink Tandem_repeat.
- BAG_domain wikiPageWikiLink Xenopus.
- BAG_domain wikiPageWikiLinkText "BAG domain".
- BAG_domain caption "crystal structure of a bag domain in complex with the hsc70 atpase domain".
- BAG_domain interpro "IPR003103".
- BAG_domain name "BAG".
- BAG_domain pfam "PF02179".
- BAG_domain scop "1".
- BAG_domain smart "BAG".
- BAG_domain symbol "BAG".
- BAG_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- BAG_domain wikiPageUsesTemplate Template:InterPro_content.
- BAG_domain wikiPageUsesTemplate Template:Reflist.
- BAG_domain subject Category:Protein_families.
- BAG_domain hypernym Domains.
- BAG_domain type Biomolecule.
- BAG_domain type Protein.
- BAG_domain type Chemical.
- BAG_domain type Thing.
- BAG_domain type Q206229.
- BAG_domain type Q8054.
- BAG_domain comment "In molecular biology, BAG domains are protein domains found in proteins which are modulators of chaperone activity, they bind to HSP70/HSC70 proteins and promote substrate release. The proteins have anti-apoptotic activity and increase the anti-cell death function of BCL-2 induced by various stimuli. BAG-1 binds to the serine/threonine kinase Raf-1 or Hsc70/Hsp70 in a mutually exclusive interaction. BAG-1 promotes cell growth by binding to and stimulating Raf-1 activity.".
- BAG_domain label "BAG domain".
- BAG_domain sameAs Q4834553.
- BAG_domain sameAs m.0gx2blf.
- BAG_domain sameAs Q4834553.
- BAG_domain wasDerivedFrom BAG_domain?oldid=590729325.
- BAG_domain depiction PDB_1hx1_EBI.jpg.
- BAG_domain isPrimaryTopicOf BAG_domain.