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- Autophagocytosis_associated_protein_Atg3 abstract "In molecular biology, autophagocytosis associated protein Atg3 is the E2 enzyme for the LC3 lipidation process. It is essential for autophagocytosis. The super protein complex, the Atg16L complex, consists of multiple Atg12-Atg5 conjugates. Atg16L has an E3-like role in the LC3 lipidation reaction. The activated intermediate, LC3-Atg3 (E2), is recruited to the site where the lipidation takes place.Atg3 catalyses the conjugation of Atg8 and phosphatidylethanolamine (PE). Atg3 has an alpha/beta-fold, and its core region is topologically similar to canonical E2 enzymes. Atg3 has two regions inserted in the core region and another with a long alpha-helical structure that protrudes from the core region as far as 30 A. It interacts with atg8 through an intermediate thioester bond between Cys-288 and the C-terminal Gly of atg8. It also interacts with the C-terminal region of the E1-like atg7 enzyme.Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the lysosome/vacuole. Atg3 is a ubiquitin like modifier that is topologically similar to the canonical E2 enzyme. It catalyses the conjugation of Atg8 and phosphatidylethanolamine.Atg3 consists of three domains, an N-terminal domain, a catalytic domain and a C-terminal domain. The catalytic domain contains a cysteine residue within an HPC motif, this is the putative active-site residue for recognition of the Apg5 subunit of the autophagosome complex. The small C-terminal domain is likely to be a distinct binding region for the stability of the autophagosome complex. It carries a highly characteristic conserved FLKF sequence motif.".
- Autophagocytosis_associated_protein_Atg3 symbol "Autophagy_Cterm".
- Autophagocytosis_associated_protein_Atg3 symbol "Autophagy_N".
- Autophagocytosis_associated_protein_Atg3 symbol "Autophagy_act_C".
- Autophagocytosis_associated_protein_Atg3 wikiPageID "32150100".
- Autophagocytosis_associated_protein_Atg3 wikiPageLength "5776".
- Autophagocytosis_associated_protein_Atg3 wikiPageOutDegree "23".
- Autophagocytosis_associated_protein_Atg3 wikiPageRevisionID "624756194".
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Alpha_helix.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Biocatalysis.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Biomolecular_structure.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink C-terminus.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Catalysis.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Category:Protein_domains.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Chemical_bond.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Conserved_sequence.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Cysteine.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Cytoplasm.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Enzyme.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Lipid-anchored_protein.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Molecular_binding.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Multiprotein_complex.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink N-terminus.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Protein–protein_interaction.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Sequence_motif.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Structural_motif.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Thioester.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Ubiquitin.
- Autophagocytosis_associated_protein_Atg3 wikiPageWikiLink Ubiquitin-conjugating_enzyme.
- Autophagocytosis_associated_protein_Atg3 caption "the crystal structure of saccharomyces cerevisiae atg3".
- Autophagocytosis_associated_protein_Atg3 interpro "IPR007134".
- Autophagocytosis_associated_protein_Atg3 interpro "IPR007135".
- Autophagocytosis_associated_protein_Atg3 interpro "IPR019461".
- Autophagocytosis_associated_protein_Atg3 name "Autophagocytosis associated protein C-terminal".
- Autophagocytosis_associated_protein_Atg3 name "Autophagocytosis associated protein N-terminal".
- Autophagocytosis_associated_protein_Atg3 name "Autophagocytosis associated protein active site domain".
- Autophagocytosis_associated_protein_Atg3 pfam "PF03986".
- Autophagocytosis_associated_protein_Atg3 pfam "PF03987".
- Autophagocytosis_associated_protein_Atg3 pfam "PF10381".
- Autophagocytosis_associated_protein_Atg3 symbol "Autophagy_Cterm".
- Autophagocytosis_associated_protein_Atg3 symbol "Autophagy_N".
- Autophagocytosis_associated_protein_Atg3 symbol "Autophagy_act_C".
- Autophagocytosis_associated_protein_Atg3 wikiPageUsesTemplate Template:Infobox_protein_family.
- Autophagocytosis_associated_protein_Atg3 wikiPageUsesTemplate Template:InterPro_content.
- Autophagocytosis_associated_protein_Atg3 wikiPageUsesTemplate Template:Orphan.
- Autophagocytosis_associated_protein_Atg3 wikiPageUsesTemplate Template:Reflist.
- Autophagocytosis_associated_protein_Atg3 subject Category:Protein_domains.
- Autophagocytosis_associated_protein_Atg3 hypernym Enzyme.
- Autophagocytosis_associated_protein_Atg3 type Biomolecule.
- Autophagocytosis_associated_protein_Atg3 type Protein.
- Autophagocytosis_associated_protein_Atg3 type Domain.
- Autophagocytosis_associated_protein_Atg3 type Thing.
- Autophagocytosis_associated_protein_Atg3 type Q206229.
- Autophagocytosis_associated_protein_Atg3 type Q8054.
- Autophagocytosis_associated_protein_Atg3 comment "In molecular biology, autophagocytosis associated protein Atg3 is the E2 enzyme for the LC3 lipidation process. It is essential for autophagocytosis. The super protein complex, the Atg16L complex, consists of multiple Atg12-Atg5 conjugates. Atg16L has an E3-like role in the LC3 lipidation reaction. The activated intermediate, LC3-Atg3 (E2), is recruited to the site where the lipidation takes place.Atg3 catalyses the conjugation of Atg8 and phosphatidylethanolamine (PE).".
- Autophagocytosis_associated_protein_Atg3 label "Autophagocytosis associated protein Atg3".
- Autophagocytosis_associated_protein_Atg3 sameAs Q4826895.
- Autophagocytosis_associated_protein_Atg3 sameAs m.0gx0yfl.
- Autophagocytosis_associated_protein_Atg3 sameAs Q4826895.
- Autophagocytosis_associated_protein_Atg3 wasDerivedFrom Autophagocytosis_associated_protein_Atg3?oldid=624756194.
- Autophagocytosis_associated_protein_Atg3 isPrimaryTopicOf Autophagocytosis_associated_protein_Atg3.