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- Aurintricarboxylic_acid abstract "Aurintricarboxylic acid (ATA) is a chemical compound that readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. It also inhibits apoptosis. It prevents down-regulation of Ca2+-impermeable GluR2 receptors and inhibits calpain, a Ca2+-activated protease that is activated during apoptosis.It is used to inhibit protein biosynthesis in its initial stages. Nominally, it is used in biological experiments as a protein inhibitor, and as an ammonium salt (known as aluminon) it is used as a reagent to estimate the aluminium in water, biological tissue, and foods.It was found that ATA is a strong inhibitor of topoisomerases and other nucleases. It might be useful for increasing efficiency of RNA isolation.It has been discovered that using aurintricarboxylic acid against influenza-A post-infection has a strong protective effect by inhibiting the virus' ability to reproduce. In cultured canine kidney cells, it was found to reduce viral reproduction and infection when applied post-infection, but not when used as a 'vaccine'. It has also been shown to block the binding of the HIV coat molecule gp120 to the CD4 co-receptor on T cells through which it invades.".
- Aurintricarboxylic_acid iupacName "5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoic acid)".
- Aurintricarboxylic_acid thumbnail Aurintricarboxylic_acid.png?width=300.
- Aurintricarboxylic_acid wikiPageID "25529458".
- Aurintricarboxylic_acid wikiPageLength "5479".
- Aurintricarboxylic_acid wikiPageOutDegree "23".
- Aurintricarboxylic_acid wikiPageRevisionID "690944699".
- Aurintricarboxylic_acid wikiPageWikiLink Aluminium.
- Aurintricarboxylic_acid wikiPageWikiLink Aluminon.
- Aurintricarboxylic_acid wikiPageWikiLink Ammonium.
- Aurintricarboxylic_acid wikiPageWikiLink Category:Phenol_dyes.
- Aurintricarboxylic_acid wikiPageWikiLink Category:Salicylic_acids.
- Aurintricarboxylic_acid wikiPageWikiLink Category:Triarylmethane_dyes.
- Aurintricarboxylic_acid wikiPageWikiLink Category:Tricarboxylic_acids.
- Aurintricarboxylic_acid wikiPageWikiLink Condensation_reaction.
- Aurintricarboxylic_acid wikiPageWikiLink Food.
- Aurintricarboxylic_acid wikiPageWikiLink Formaldehyde.
- Aurintricarboxylic_acid wikiPageWikiLink Human_subject_research.
- Aurintricarboxylic_acid wikiPageWikiLink Infection.
- Aurintricarboxylic_acid wikiPageWikiLink Influenza_A_virus.
- Aurintricarboxylic_acid wikiPageWikiLink Kidney.
- Aurintricarboxylic_acid wikiPageWikiLink Nucleic_acid_methods.
- Aurintricarboxylic_acid wikiPageWikiLink Protein_biosynthesis.
- Aurintricarboxylic_acid wikiPageWikiLink Reagent.
- Aurintricarboxylic_acid wikiPageWikiLink Salicylic_acid.
- Aurintricarboxylic_acid wikiPageWikiLink Tissue_(biology).
- Aurintricarboxylic_acid wikiPageWikiLink Vaccine.
- Aurintricarboxylic_acid wikiPageWikiLink Viral_replication.
- Aurintricarboxylic_acid wikiPageWikiLink Virus.
- Aurintricarboxylic_acid wikiPageWikiLink Water.
- Aurintricarboxylic_acid wikiPageWikiLinkText "Aurintricarboxylic acid".
- Aurintricarboxylic_acid wikiPageWikiLinkText "aurintricarboxylic acid".
- Aurintricarboxylic_acid imagealt "Ball-and-stick model of the aurintricarboxylic acid molecule".
- Aurintricarboxylic_acid imagealt "Skeletal formula of aurintricarboxylic acid".
- Aurintricarboxylic_acid imagefile "Aurintricarboxylic acid.png".
- Aurintricarboxylic_acid imagefile "Aurintricarboxylic-acid-3D-balls.png".
- Aurintricarboxylic_acid iupacname "55".
- Aurintricarboxylic_acid othernames "Aluminon free acid".
- Aurintricarboxylic_acid verifiedrevid "413875357".
- Aurintricarboxylic_acid watchedfields "changed".
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Cascite.
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Chembox.
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Chembox_Hazards.
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Chembox_Identifiers.
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Chembox_Properties.
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Chemboximage.
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Chemspidercite.
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Cn.
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Ebicite.
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Reflist.
- Aurintricarboxylic_acid wikiPageUsesTemplate Template:Stdinchicite.
- Aurintricarboxylic_acid subject Category:Phenol_dyes.
- Aurintricarboxylic_acid subject Category:Salicylic_acids.
- Aurintricarboxylic_acid subject Category:Triarylmethane_dyes.
- Aurintricarboxylic_acid subject Category:Tricarboxylic_acids.
- Aurintricarboxylic_acid hypernym Compound.
- Aurintricarboxylic_acid type ChemicalCompound.
- Aurintricarboxylic_acid type ChemicalSubstance.
- Aurintricarboxylic_acid type ChemicalObject.
- Aurintricarboxylic_acid type Thing.
- Aurintricarboxylic_acid type Q11173.
- Aurintricarboxylic_acid comment "Aurintricarboxylic acid (ATA) is a chemical compound that readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.".
- Aurintricarboxylic_acid label "Aurintricarboxylic acid".
- Aurintricarboxylic_acid sameAs Q4822390.
- Aurintricarboxylic_acid sameAs آورینتریکربوکسیلیک_اسید.
- Aurintricarboxylic_acid sameAs m.09v3m4v.
- Aurintricarboxylic_acid sameAs Aurintrikarboksilna_kiselina.
- Aurintricarboxylic_acid sameAs Aurintrikarboksilna_kiselina.
- Aurintricarboxylic_acid sameAs Q4822390.
- Aurintricarboxylic_acid wasDerivedFrom Aurintricarboxylic_acid?oldid=690944699.
- Aurintricarboxylic_acid depiction Aurintricarboxylic_acid.png.
- Aurintricarboxylic_acid isPrimaryTopicOf Aurintricarboxylic_acid.
