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- Atypical_chronic_myeloid_leukemia abstract "Atypical chronic myeloid leukemia (aCML) is a type of leukemia. It is a heterogeneous disorder belonging to the group of myelodysplastic/myeloproliferative (MDS/MPN) syndromes. In aCML many clinical features (splenomegaly, myeloid predominance in the bone marrow with some dysplastic features but without a differentiation block) and laboratory abnormalities (myeloid proliferation, low leukocyte alkaline phosphatase values) suggest the diagnosis of chronic myelogenous leukemia (CML). However the lack of the pathognomonic Philadelphia chromosome and of the resulting BCR-ABL1 fusion point to a different pathogenetic process. Since no specific recurrent genomic or karyotypic abnormalities have been identified in aCML, the molecular pathogenesis of this disease has remained elusive and the outcome dismal (median survival 37 months)with no improvement over the last 20 years. This sharply contrasts with the outcome for CML, for which the prognosis was dramatically improved by the development of imatinib as a specific inhibitor of the BCR-ABL protein and in particular for CML.In 2012 SETBP1 was identified as a novel oncogene in aCML; specific somatic mutations of this gene were discovered in people with aCML and related diseases. These mutations, which are identical to the ones present in SGS as germline mutations, impair the degradation of SETBP1 and therefore cause increased cellular levels of the protein.".
- Atypical_chronic_myeloid_leukemia wikiPageID "38813055".
- Atypical_chronic_myeloid_leukemia wikiPageLength "3171".
- Atypical_chronic_myeloid_leukemia wikiPageOutDegree "8".
- Atypical_chronic_myeloid_leukemia wikiPageRevisionID "621561374".
- Atypical_chronic_myeloid_leukemia wikiPageWikiLink Category:Leukemia.
- Atypical_chronic_myeloid_leukemia wikiPageWikiLink Chronic_myelogenous_leukemia.
- Atypical_chronic_myeloid_leukemia wikiPageWikiLink Germline_mutation.
- Atypical_chronic_myeloid_leukemia wikiPageWikiLink Imatinib.
- Atypical_chronic_myeloid_leukemia wikiPageWikiLink Leukemia.
- Atypical_chronic_myeloid_leukemia wikiPageWikiLink Philadelphia_chromosome.
- Atypical_chronic_myeloid_leukemia wikiPageWikiLink SETBP1.
- Atypical_chronic_myeloid_leukemia wikiPageWikiLink Splenomegaly.
- Atypical_chronic_myeloid_leukemia wikiPageWikiLinkText "Atypical chronic myeloid leukemia".
- Atypical_chronic_myeloid_leukemia subject Category:Leukemia.
- Atypical_chronic_myeloid_leukemia hypernym Leukemia.
- Atypical_chronic_myeloid_leukemia type Disease.
- Atypical_chronic_myeloid_leukemia comment "Atypical chronic myeloid leukemia (aCML) is a type of leukemia. It is a heterogeneous disorder belonging to the group of myelodysplastic/myeloproliferative (MDS/MPN) syndromes. In aCML many clinical features (splenomegaly, myeloid predominance in the bone marrow with some dysplastic features but without a differentiation block) and laboratory abnormalities (myeloid proliferation, low leukocyte alkaline phosphatase values) suggest the diagnosis of chronic myelogenous leukemia (CML).".
- Atypical_chronic_myeloid_leukemia label "Atypical chronic myeloid leukemia".
- Atypical_chronic_myeloid_leukemia sameAs Q11663712.
- Atypical_chronic_myeloid_leukemia sameAs 非定型慢性骨髄性白血病.
- Atypical_chronic_myeloid_leukemia sameAs Atipinė_lėtinė_mieloleukemija.
- Atypical_chronic_myeloid_leukemia sameAs m.04klpbt.
- Atypical_chronic_myeloid_leukemia sameAs Q11663712.
- Atypical_chronic_myeloid_leukemia wasDerivedFrom Atypical_chronic_myeloid_leukemia?oldid=621561374.
- Atypical_chronic_myeloid_leukemia isPrimaryTopicOf Atypical_chronic_myeloid_leukemia.