Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Asymmetric_addition_of_alkenylmetals_to_aldehydes> ?p ?o }
Showing triples 1 to 34 of
34
with 100 triples per page.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes abstract "Asymmetric addition of alkenylmetals to aldehydes is a chemical reaction in enantioselective synthesis that reacts an alkenylmetal with an aldehyde to give an allyl alcohol (Figure \"Asymmetric addition of alkenylmetals to aldehydes\"). The stereoselectivity in the reaction is typically controlled by the asymmetric ligands used providing a strategy to introduce controlled asymmetry into the molecule. Controlled molecular asymmetry (or enantioselectivity) is crucial for controlling the bioactivity of the synthesized molecules and demanded by drug authorities in drug synthesis. In this case the ligands chelate to the transition metal to create a chiral environment which enables the selective formation of a particular enantiomer. Various transition metals such as Zinc, Nickel, Chromium, and Rhodium have been used in this reaction.Asymmetric addition of alkenylmetals to aldehydes has been widely used in total synthesis of natural product. For example, the key cyclization step in the total synthesis of (R)-(-)-Muscone was an intramolecular asymmetric addition of a vinylzinc derivative to an aldehyde using a chiral amino-isoborneol ligand (Figure \"(a) Asymmetric addition of alkenylzinc to aldehyde in the total synthesis of muscone\"). The reaction used a terminal alkyne (A) as the substrate which generated alkenylborate reagent (B) through monohydroboration reaction. After transmetalation with diethylzinc, the generated alkenylzinc reagent (C) further reacted with the aldehyde (D) through exclusive addition to the π-face under the control of (-)-3-exo-(dimethylamino)isoborneol (DAIB) as a ligand (Figure \"(b) Detailed steps for the reaction\").".
- Asymmetric_addition_of_alkenylmetals_to_aldehydes thumbnail Asymmetric_addition_of_alkenylmetals_to_aldehydes.png?width=300.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageID "45199567".
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageLength "2847".
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageOutDegree "18".
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageRevisionID "689611626".
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Aldehyde.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Alkyne.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Allyl_alcohol.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Borneol.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Category:Chemical_reactions.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Chromium.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Diethylzinc.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Enantiomer.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Enantioselective_synthesis.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Ligand.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Muscone.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Nickel.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Rhodium.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Stereoselectivity.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Transmetalation.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink Zinc.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink File:(a)_Asymmetric_addition_of_alkenylzinc_to_aldehyde_in_the_total_synthesis_of_muscone._(b)_Detailed_steps_for_the_reaction._Structure_of_the_ligand_and_the_proposed_transition_state_for_the_key_addition_reaction_are_shown..png.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLink File:Asymmetric_addition_of_alkenylmetals_to_aldehydes.png.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageWikiLinkText "Asymmetric addition of alkenylmetals to aldehydes".
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wikiPageUsesTemplate Template:Reflist.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes subject Category:Chemical_reactions.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes hypernym Reaction.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes type Disease.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes comment "Asymmetric addition of alkenylmetals to aldehydes is a chemical reaction in enantioselective synthesis that reacts an alkenylmetal with an aldehyde to give an allyl alcohol (Figure \"Asymmetric addition of alkenylmetals to aldehydes\"). The stereoselectivity in the reaction is typically controlled by the asymmetric ligands used providing a strategy to introduce controlled asymmetry into the molecule.".
- Asymmetric_addition_of_alkenylmetals_to_aldehydes label "Asymmetric addition of alkenylmetals to aldehydes".
- Asymmetric_addition_of_alkenylmetals_to_aldehydes wasDerivedFrom Asymmetric_addition_of_alkenylmetals_to_aldehydes?oldid=689611626.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes depiction Asymmetric_addition_of_alkenylmetals_to_aldehydes.png.
- Asymmetric_addition_of_alkenylmetals_to_aldehydes isPrimaryTopicOf Asymmetric_addition_of_alkenylmetals_to_aldehydes.