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- Ascomycin abstract "Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It has been researched for the treatment of autoimmune diseases and skin diseases, and to prevent rejection after an organ transplant.Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines. Additionally, ascomycin preferentially inhibits the activation of mast cells, an important cellular component of the atopic response. Ascomycin produces a more selective immunomodulatory effect in that it inhibits the elicitation phase of allergic contact dermatitis but does not impair the primary immune response when administered systemically.Ascomycin is produced by the fermentation of Streptomyces hygroscopicus.".
- Ascomycin atcPrefix "none".
- Ascomycin casNumber "11011-38-4".
- Ascomycin chEBI "29582".
- Ascomycin iupacName "(3S,​4R,​5S,​8R,​9Z,​12S,​14S,​15R,​16S,​18R,​19R,​26aS)-​8-​ethyl-​5,​19-​dihydroxy-​3-​{(E)-​2-​[(1R,​3R,​4R)-​4-​hydroxy-​3-​methoxycyclohexyl]-​1-​methylvinyl}-​14,​16-​dimethoxy-​4,​10,​12,​18-​tetramethyl-​4,​5,​6,​8,​11,​12,​13,​14,​15,​16,​17,​18,​19,​24,​25,​26,​26a-​heptadecahydro-​3H-​15,​19-​epoxypyrido[2,1-c]​[1,4]oxazacyclotriclosine-1,​7,​20,​21(23H)-​tetrone".
- Ascomycin pubchem "5282071".
- Ascomycin thumbnail Ascomycin_structure.png?width=300.
- Ascomycin wikiPageExternalLink 1728_55822.htm.
- Ascomycin wikiPageID "3933000".
- Ascomycin wikiPageLength "5745".
- Ascomycin wikiPageOutDegree "19".
- Ascomycin wikiPageRevisionID "629388721".
- Ascomycin wikiPageWikiLink Allergic_contact_dermatitis.
- Ascomycin wikiPageWikiLink Autoimmune_disease.
- Ascomycin wikiPageWikiLink Category:Immunosuppressants.
- Ascomycin wikiPageWikiLink Cities_in_Flight.
- Ascomycin wikiPageWikiLink Cytokine.
- Ascomycin wikiPageWikiLink Ethyl_group.
- Ascomycin wikiPageWikiLink Fermentation.
- Ascomycin wikiPageWikiLink Immunophilins.
- Ascomycin wikiPageWikiLink Immunotherapy.
- Ascomycin wikiPageWikiLink James_Blish.
- Ascomycin wikiPageWikiLink List_of_cutaneous_conditions.
- Ascomycin wikiPageWikiLink List_of_fictional_medicines_and_drugs.
- Ascomycin wikiPageWikiLink Macrophilin-12.
- Ascomycin wikiPageWikiLink Mast_cell.
- Ascomycin wikiPageWikiLink Organ_transplantation.
- Ascomycin wikiPageWikiLink Pimecrolimus.
- Ascomycin wikiPageWikiLink Streptomyces_hygroscopicus.
- Ascomycin wikiPageWikiLink Tacrolimus.
- Ascomycin wikiPageWikiLinkText "Ascomycin".
- Ascomycin wikiPageWikiLinkText "ascomycin".
- Ascomycin atcPrefix "none".
- Ascomycin c "43".
- Ascomycin casNumber "11011".
- Ascomycin chebi "29582".
- Ascomycin chembl "8597".
- Ascomycin chemspiderid "4445297".
- Ascomycin h "69".
- Ascomycin iupacName "-​8-​ethyl-​5,​19-​dihydroxy-​3-​{-​2-​[-​4-​hydroxy-​3-​methoxycyclohexyl]-​1-​methylvinyl}-​14,​16-​dimethoxy-​4,​10,​12,​18-​tetramethyl-​4,​5,​6,​8,​11,​12,​13,​14,​15,​16,​17,​18,​19,​24,​25,​26,​26a-​heptadecahydro-​3H-​15,​19-​epoxypyrido[2,1-c]​[1,4]oxazacyclotriclosine-1,​7,​20,​21-​tetrone".
- Ascomycin molecularWeight "792.01".
- Ascomycin n "1".
- Ascomycin o "12".
- Ascomycin pubchem "5282071".
- Ascomycin smiles "O=C3CN1CCCC[C@H]1CO[C@H][C@H][C@@H]CC[C@@H]CC".
- Ascomycin stdinchi "1".
- Ascomycin stdinchikey "ZDQSOHOQTUFQEM-NURRSENYSA-N".
- Ascomycin synonyms "(17-ethyl-1,14-dihydroxy-12-[2--1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone)".
- Ascomycin verifiedfields "changed".
- Ascomycin verifiedrevid "457820106".
- Ascomycin wikiPageUsesTemplate Template:Cascite.
- Ascomycin wikiPageUsesTemplate Template:Chemspidercite.
- Ascomycin wikiPageUsesTemplate Template:Drugbankcite.
- Ascomycin wikiPageUsesTemplate Template:Drugbox.
- Ascomycin wikiPageUsesTemplate Template:Ebicite.
- Ascomycin wikiPageUsesTemplate Template:Stdinchicite.
- Ascomycin subject Category:Immunosuppressants.
- Ascomycin hypernym Analog.
- Ascomycin type ChemicalSubstance.
- Ascomycin type Drug.
- Ascomycin type Chemical.
- Ascomycin type Drug.
- Ascomycin type Immunosuppressant.
- Ascomycin type ChemicalObject.
- Ascomycin type Thing.
- Ascomycin type Q8386.
- Ascomycin comment "Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It has been researched for the treatment of autoimmune diseases and skin diseases, and to prevent rejection after an organ transplant.Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines.".
- Ascomycin label "Ascomycin".
- Ascomycin sameAs Q4803998.
- Ascomycin sameAs m.0b7fln.
- Ascomycin sameAs Askomicin.
- Ascomycin sameAs Askomicin.
- Ascomycin sameAs Q4803998.
- Ascomycin wasDerivedFrom Ascomycin?oldid=629388721.
- Ascomycin depiction Ascomycin_structure.png.
- Ascomycin isPrimaryTopicOf Ascomycin.