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- Artificial_enzyme abstract "An artificial enzyme is a synthetic, organic molecule prepared to recreate the active site of an enzyme.Enzyme catalysis of chemical reactions occur with high selectivity and rate in a small part of the enzyme macromolecule known as the active site. There, the binding of a substrate close to functional groups in the enzyme causes catalysis by so-called proximity effects. It is therefore possible to create similar catalysts from small molecule mimics of enzyme active sites by combining, in a small molecule, the ability to bind substrate with catalytic functional groups. Since the artificial enzymes need to bind molecules, they are made based on a host-molecule such as a cyclodextrin, crown ethers or calixarene etc.A number of artificial enzymes have been reported catalysing various reactions with rate increases up to 103; this is nevertheless substantially lower than natural enzymes that typically causes rate increases above 106. One of the pioneers in artificial enzyme research is chemist Ronald Breslow.New approaches based on amino acids or peptides as characteristic molecular moieties have led to a significant expansion of the field of artificial enzymes or enzyme mimics. For instance, recent results by the group of Rob Liskamp have shown that scaffolded histidine residues can be used as mimics of certain metalloproteins and -enzymes. Especially the structural mimicry of certain copper proteins (e.g. hemocyanin, tyrosinase and catechol oxidase), containing so-called type-3 copper binding sites, has been shown. This is a significant improvement since the use of scaffolded histidine residues is one step closer to the mimicry of enzymes by biological relevant species such as amino acids and peptides.".
- Artificial_enzyme thumbnail Artificial_enzyme.jpg?width=300.
- Artificial_enzyme wikiPageID "11448262".
- Artificial_enzyme wikiPageLength "6506".
- Artificial_enzyme wikiPageOutDegree "22".
- Artificial_enzyme wikiPageRevisionID "704352684".
- Artificial_enzyme wikiPageWikiLink Active_site.
- Artificial_enzyme wikiPageWikiLink Amino_acid.
- Artificial_enzyme wikiPageWikiLink Calixarene.
- Artificial_enzyme wikiPageWikiLink Catalysis.
- Artificial_enzyme wikiPageWikiLink Catechol_oxidase.
- Artificial_enzyme wikiPageWikiLink Category:Enzymes.
- Artificial_enzyme wikiPageWikiLink Category:Synthetic_biology.
- Artificial_enzyme wikiPageWikiLink Copper_protein.
- Artificial_enzyme wikiPageWikiLink Crown_ether.
- Artificial_enzyme wikiPageWikiLink Cyclodextrin.
- Artificial_enzyme wikiPageWikiLink Enzyme.
- Artificial_enzyme wikiPageWikiLink Functional_group.
- Artificial_enzyme wikiPageWikiLink Hemocyanin.
- Artificial_enzyme wikiPageWikiLink Metalloprotein.
- Artificial_enzyme wikiPageWikiLink Peptide.
- Artificial_enzyme wikiPageWikiLink Ronald_Breslow.
- Artificial_enzyme wikiPageWikiLink Small_molecule.
- Artificial_enzyme wikiPageWikiLink Substrate_(chemistry).
- Artificial_enzyme wikiPageWikiLink Tyrosinase.
- Artificial_enzyme wikiPageWikiLink File:Artificial_enzyme.jpg.
- Artificial_enzyme wikiPageWikiLink File:C3cs35486e-f1.gif.
- Artificial_enzyme wikiPageWikiLinkText "Artificial enzyme".
- Artificial_enzyme wikiPageWikiLinkText "artificial enzyme".
- Artificial_enzyme wikiPageUsesTemplate Template:For.
- Artificial_enzyme wikiPageUsesTemplate Template:Refimprove.
- Artificial_enzyme wikiPageUsesTemplate Template:Reflist.
- Artificial_enzyme subject Category:Enzymes.
- Artificial_enzyme subject Category:Synthetic_biology.
- Artificial_enzyme hypernym Molecule.
- Artificial_enzyme type ChemicalCompound.
- Artificial_enzyme comment "An artificial enzyme is a synthetic, organic molecule prepared to recreate the active site of an enzyme.Enzyme catalysis of chemical reactions occur with high selectivity and rate in a small part of the enzyme macromolecule known as the active site. There, the binding of a substrate close to functional groups in the enzyme causes catalysis by so-called proximity effects.".
- Artificial_enzyme label "Artificial enzyme".
- Artificial_enzyme sameAs Q2914572.
- Artificial_enzyme sameAs Enzim_artificial.
- Artificial_enzyme sameAs Enzyme_artificielle.
- Artificial_enzyme sameAs אנזים_מלאכותי.
- Artificial_enzyme sameAs 人工酵素.
- Artificial_enzyme sameAs Sztuczny_enzym.
- Artificial_enzyme sameAs m.02rc_nn.
- Artificial_enzyme sameAs Q2914572.
- Artificial_enzyme sameAs 人工酶.
- Artificial_enzyme wasDerivedFrom Artificial_enzyme?oldid=704352684.
- Artificial_enzyme depiction Artificial_enzyme.jpg.
- Artificial_enzyme isPrimaryTopicOf Artificial_enzyme.