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- Apaziquone abstract "Apaziquone (EOquin) is an indolequinone that is a bioreductive prodrug and a chemical analog of the older chemotherapeutic agent mitomycin C. In hypoxic cells, such as those on the inner surface of the urinary bladder, apaziquone is converted to active metabolites by intracellular reductases. The active metabolites alkylate DNA and lead to apoptotic cell death. This activity is preferentially expressed in neoplastic cells.After administration of apaziquone directly into the urinary bladder, the drug and its active metabolite were not detected in plasma, and there were no systemic side effectsApaziquone has been applied in clinical studies sponsored by Spectrum Pharmaceuticals and Allergan, Inc. for the treatment of superficial (non-muscle invasive) bladder cancer. Approximately 70% of all newly diagnosed patients with bladder cancer have non-muscle invasive bladder cancer and over one million patients in the United States and Europe are affected by the disease. The US Food and Drug Administration (FDA) has granted Fast Track review status to apaziquone for this indication.".
- Apaziquone atcPrefix "none".
- Apaziquone casNumber "114560-48-4".
- Apaziquone fdaUniiCode "H464ZO600O".
- Apaziquone iupacName "(E)-5-(1-Azirinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione".
- Apaziquone pubchem "5813717".
- Apaziquone thumbnail Apaziquone.svg?width=300.
- Apaziquone wikiPageID "23150392".
- Apaziquone wikiPageLength "4838".
- Apaziquone wikiPageOutDegree "20".
- Apaziquone wikiPageRevisionID "659014465".
- Apaziquone wikiPageWikiLink Allergan,_Inc..
- Apaziquone wikiPageWikiLink Apoptosis.
- Apaziquone wikiPageWikiLink Blood_plasma.
- Apaziquone wikiPageWikiLink Category:Alcohols.
- Apaziquone wikiPageWikiLink Category:Antineoplastic_drugs.
- Apaziquone wikiPageWikiLink Category:Aziridines.
- Apaziquone wikiPageWikiLink Category:Indoles.
- Apaziquone wikiPageWikiLink Category:Quinones.
- Apaziquone wikiPageWikiLink Chemotherapy.
- Apaziquone wikiPageWikiLink Food_and_Drug_Administration.
- Apaziquone wikiPageWikiLink Hypoxia_(medical).
- Apaziquone wikiPageWikiLink Mitomycins.
- Apaziquone wikiPageWikiLink Neoplasm.
- Apaziquone wikiPageWikiLink Prodrug.
- Apaziquone wikiPageWikiLink Reductase.
- Apaziquone wikiPageWikiLink Side_effect.
- Apaziquone wikiPageWikiLink Spectrum_Pharmaceuticals.
- Apaziquone wikiPageWikiLink Structural_analog.
- Apaziquone wikiPageWikiLink Urinary_bladder.
- Apaziquone wikiPageWikiLinkText "Apaziquone".
- Apaziquone wikiPageWikiLinkText "apaziquone".
- Apaziquone atcPrefix "none".
- Apaziquone c "15".
- Apaziquone casNumber "114560".
- Apaziquone chembl "73822".
- Apaziquone chemspiderid "4710342".
- Apaziquone h "16".
- Apaziquone inchi "1".
- Apaziquone inchikey "MXPOCMVWFLDDLZ-NSCUHMNNSA-N".
- Apaziquone iupacName "-5".
- Apaziquone kegg "D02965".
- Apaziquone molecularWeight "288".
- Apaziquone n "2".
- Apaziquone o "4".
- Apaziquone pubchem "5813717".
- Apaziquone smiles "Cn1c/C=C/CO".
- Apaziquone stdinchi "1".
- Apaziquone stdinchikey "MXPOCMVWFLDDLZ-NSCUHMNNSA-N".
- Apaziquone unii "H464ZO600O".
- Apaziquone verifiedfields "changed".
- Apaziquone verifiedrevid "457134883".
- Apaziquone wikiPageUsesTemplate Template:Cascite.
- Apaziquone wikiPageUsesTemplate Template:Chemspidercite.
- Apaziquone wikiPageUsesTemplate Template:Drugbankcite.
- Apaziquone wikiPageUsesTemplate Template:Drugbox.
- Apaziquone wikiPageUsesTemplate Template:Ebicite.
- Apaziquone wikiPageUsesTemplate Template:Fdacite.
- Apaziquone wikiPageUsesTemplate Template:Keggcite.
- Apaziquone wikiPageUsesTemplate Template:Reflist.
- Apaziquone wikiPageUsesTemplate Template:Stdinchicite.
- Apaziquone subject Category:Alcohols.
- Apaziquone subject Category:Antineoplastic_drugs.
- Apaziquone subject Category:Aziridines.
- Apaziquone subject Category:Indoles.
- Apaziquone subject Category:Quinones.
- Apaziquone hypernym Indolequinone.
- Apaziquone type ChemicalSubstance.
- Apaziquone type Drug.
- Apaziquone type Alcohol.
- Apaziquone type Chemical.
- Apaziquone type Drug.
- Apaziquone type Heterocycle.
- Apaziquone type Ketone.
- Apaziquone type Quinone.
- Apaziquone type ChemicalObject.
- Apaziquone type Thing.
- Apaziquone type Q8386.
- Apaziquone comment "Apaziquone (EOquin) is an indolequinone that is a bioreductive prodrug and a chemical analog of the older chemotherapeutic agent mitomycin C. In hypoxic cells, such as those on the inner surface of the urinary bladder, apaziquone is converted to active metabolites by intracellular reductases. The active metabolites alkylate DNA and lead to apoptotic cell death.".
- Apaziquone label "Apaziquone".
- Apaziquone sameAs Q4779259.
- Apaziquone sameAs m.064kh46.
- Apaziquone sameAs Apazikvon.
- Apaziquone sameAs Apazikvon.
- Apaziquone sameAs Q4779259.
- Apaziquone wasDerivedFrom Apaziquone?oldid=659014465.
- Apaziquone depiction Apaziquone.svg.
- Apaziquone isPrimaryTopicOf Apaziquone.