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- Antitarget abstract "In pharmacology, an antitarget is a receptor, enzyme, or other biological target that, when affected by a drug, causes undesirable side-effects. During drug design and development, it is important for pharmaceutical companies to ensure that new drugs do not show significant activity at any of a range of antitargets, most of which are discovered largely by chance.Among the best-known and most significant antitargets are the hERG channel and the 5-HT2B receptor, both of which causing long-term problems with heart function that can prove fatal (long QT syndrome and cardiac fibrosis, respectively), in a small but unpredictable proportion of users. Both of these targets were discovered as a result of high levels of distinctive side-effects during the marketing of certain medicines, and, while some older drugs with significant hERG activity are still used with caution, most drugs that have been found to be strong 5-HT2B agonists were withdrawn from the market, and any new compound will almost always be discontinued from further development if initial screening shows high affinity for these targets.".
- Antitarget wikiPageID "24510339".
- Antitarget wikiPageLength "5119".
- Antitarget wikiPageOutDegree "14".
- Antitarget wikiPageRevisionID "699788948".
- Antitarget wikiPageWikiLink 5-HT2B_receptor.
- Antitarget wikiPageWikiLink Adverse_effect.
- Antitarget wikiPageWikiLink Biological_target.
- Antitarget wikiPageWikiLink Cardiac_fibrosis.
- Antitarget wikiPageWikiLink Category:Drug_discovery.
- Antitarget wikiPageWikiLink Category:Medicinal_chemistry.
- Antitarget wikiPageWikiLink Category:Pharmaceutical_industry.
- Antitarget wikiPageWikiLink Drug_design.
- Antitarget wikiPageWikiLink Drug_development.
- Antitarget wikiPageWikiLink Enzyme.
- Antitarget wikiPageWikiLink HERG.
- Antitarget wikiPageWikiLink Long_QT_syndrome.
- Antitarget wikiPageWikiLink Pharmacology.
- Antitarget wikiPageWikiLink Receptor_(biochemistry).
- Antitarget wikiPageWikiLinkText "Antitarget".
- Antitarget wikiPageWikiLinkText "antitarget".
- Antitarget wikiPageUsesTemplate Template:Reflist.
- Antitarget subject Category:Drug_discovery.
- Antitarget subject Category:Medicinal_chemistry.
- Antitarget subject Category:Pharmaceutical_industry.
- Antitarget hypernym Receptor.
- Antitarget type Protein.
- Antitarget type Science.
- Antitarget comment "In pharmacology, an antitarget is a receptor, enzyme, or other biological target that, when affected by a drug, causes undesirable side-effects.".
- Antitarget label "Antitarget".
- Antitarget sameAs Q4775330.
- Antitarget sameAs Antitarget.
- Antitarget sameAs m.080dgx3.
- Antitarget sameAs Q4775330.
- Antitarget sameAs 抗靶标.
- Antitarget wasDerivedFrom Antitarget?oldid=699788948.
- Antitarget isPrimaryTopicOf Antitarget.