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- Antigenic_escape abstract "Antigenic escape occurs when the immune system is unable to respond to an infectious agent. This means that the response mechanisms a host's immune system normally utilizes to recognize and eliminate a virus or pathogen is no longer able to do so. This process can occur in a number of different mechanism of both genetic and environmental nature. Such mechanisms include homologous recombination, and manipulation and resistance of the host's immune responses.Different antigens are able to escape through a variety of mechanisms. For example, the African Trypanosome parasites are able to clear the host's antibodies, as well as resist lysis and inhibit parts of the innate immune response. Another bacteria, Bordetella pertussis, is able to escape the immune response by inhibiting neutrophils and macrophages from invading the infection site early on. One cause of Antigenic escape is that a pathogen's epitopes (the binding sites for immune cells) become too similar to a person's naturally occurring MHC-1 epitopes. The immune system becomes unable to distinguish the infection from self-cells.Antigenic escape is not only crucial for resistance of a host's natural immune response, but also for the resistance against vaccinations. The problem of antigenic escape has greatly deterred the process of creating new vaccines. Because vaccines generally cover a small ratio of strains of one virus, the recombination of antigenic DNA that lead to diverse pathogens allows these invaders to resist even newly developed vaccinations. Some antigens may even target pathways different than those the vaccine had originally intended to target. Recent research on many vaccines, including the malaria vaccine, has focused on how to anticipate this diversity and create vaccinations that can cover a broader spectrum of antigenic variation.".
- Antigenic_escape wikiPageID "11026468".
- Antigenic_escape wikiPageLength "7532".
- Antigenic_escape wikiPageOutDegree "7".
- Antigenic_escape wikiPageRevisionID "707647632".
- Antigenic_escape wikiPageWikiLink Category:Cell_biology.
- Antigenic_escape wikiPageWikiLink Epitope.
- Antigenic_escape wikiPageWikiLink Immune_system.
- Antigenic_escape wikiPageWikiLink MHC_class_I.
- Antigenic_escape wikiPageWikiLink Pathogen.
- Antigenic_escape wikiPageWikiLink White_blood_cell.
- Antigenic_escape wikiPageUsesTemplate Template:Orphan.
- Antigenic_escape wikiPageUsesTemplate Template:Reflist.
- Antigenic_escape subject Category:Cell_biology.
- Antigenic_escape comment "Antigenic escape occurs when the immune system is unable to respond to an infectious agent. This means that the response mechanisms a host's immune system normally utilizes to recognize and eliminate a virus or pathogen is no longer able to do so. This process can occur in a number of different mechanism of both genetic and environmental nature.".
- Antigenic_escape label "Antigenic escape".
- Antigenic_escape sameAs Q4774740.
- Antigenic_escape sameAs هروب_مستضدي.
- Antigenic_escape sameAs m.02qyhqb.
- Antigenic_escape sameAs Q4774740.
- Antigenic_escape wasDerivedFrom Antigenic_escape?oldid=707647632.
- Antigenic_escape isPrimaryTopicOf Antigenic_escape.