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- Antifolate abstract "Antifolates are drugs that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR).".
- Antifolate thumbnail Dihydrofolate_reductase_1DRF.png?width=300.
- Antifolate wikiPageID "14250274".
- Antifolate wikiPageLength "8413".
- Antifolate wikiPageOutDegree "43".
- Antifolate wikiPageRevisionID "670157561".
- Antifolate wikiPageWikiLink Bone_marrow.
- Antifolate wikiPageWikiLink Category:Antifolates.
- Antifolate wikiPageWikiLink Chronic_obstructive_pulmonary_disease.
- Antifolate wikiPageWikiLink Competitive_inhibition.
- Antifolate wikiPageWikiLink Dihydrofolate_reductase.
- Antifolate wikiPageWikiLink Drug.
- Antifolate wikiPageWikiLink Drug_resistance.
- Antifolate wikiPageWikiLink Folate_deficiency.
- Antifolate wikiPageWikiLink Folic_acid.
- Antifolate wikiPageWikiLink Goodpasture_syndrome.
- Antifolate wikiPageWikiLink Granulomatosis_with_polyangiitis.
- Antifolate wikiPageWikiLink Hair.
- Antifolate wikiPageWikiLink Listeria.
- Antifolate wikiPageWikiLink Malaria.
- Antifolate wikiPageWikiLink Melioidosis.
- Antifolate wikiPageWikiLink Mesothelioma.
- Antifolate wikiPageWikiLink Methotrexate.
- Antifolate wikiPageWikiLink Non-small-cell_lung_carcinoma.
- Antifolate wikiPageWikiLink Osteosarcoma.
- Antifolate wikiPageWikiLink Pemetrexed.
- Antifolate wikiPageWikiLink Pneumocystis_pneumonia.
- Antifolate wikiPageWikiLink Pralatrexate.
- Antifolate wikiPageWikiLink Proguanil.
- Antifolate wikiPageWikiLink Psoriasis.
- Antifolate wikiPageWikiLink Pyrimethamine.
- Antifolate wikiPageWikiLink Raltitrexed.
- Antifolate wikiPageWikiLink Rheumatoid_arthritis.
- Antifolate wikiPageWikiLink Shigellosis.
- Antifolate wikiPageWikiLink Skin.
- Antifolate wikiPageWikiLink Stevens–Johnson_syndrome.
- Antifolate wikiPageWikiLink Stomatitis.
- Antifolate wikiPageWikiLink Sulfonamide.
- Antifolate wikiPageWikiLink Teratology.
- Antifolate wikiPageWikiLink Toxic_epidermal_necrolysis.
- Antifolate wikiPageWikiLink Toxoplasmosis.
- Antifolate wikiPageWikiLink Trimethoprim.
- Antifolate wikiPageWikiLink Urinary_tract_infection.
- Antifolate wikiPageWikiLink File:Dihydrofolate_reductase_1DRF.png.
- Antifolate wikiPageWikiLink File:Folic_acid.svg.
- Antifolate wikiPageWikiLinkText "Antifolate".
- Antifolate wikiPageWikiLinkText "anti-folates".
- Antifolate wikiPageWikiLinkText "antifolate".
- Antifolate wikiPageWikiLinkText "blocking the making of folate".
- Antifolate wikiPageUsesTemplate Template:Antimalarials.
- Antifolate wikiPageUsesTemplate Template:Chemotherapeutic_agents.
- Antifolate wikiPageUsesTemplate Template:MeshName.
- Antifolate wikiPageUsesTemplate Template:Purinergics.
- Antifolate wikiPageUsesTemplate Template:Reflist.
- Antifolate wikiPageUsesTemplate Template:Sulfonamides_and_trimethoprim.
- Antifolate subject Category:Antifolates.
- Antifolate hypernym Drugs.
- Antifolate type Drug.
- Antifolate type Concept.
- Antifolate comment "Antifolates are drugs that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis.".
- Antifolate label "Antifolate".
- Antifolate sameAs Q4774725.
- Antifolate sameAs مضاد_الفولات.
- Antifolate sameAs Antifolato.
- Antifolate sameAs m.047vls4.
- Antifolate sameAs Antifolat.
- Antifolate sameAs Antifolat.
- Antifolate sameAs Q4774725.
- Antifolate wasDerivedFrom Antifolate?oldid=670157561.
- Antifolate depiction Dihydrofolate_reductase_1DRF.png.
- Antifolate isPrimaryTopicOf Antifolate.