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- Antalarmin abstract "Antalarmin is a drug that acts as a CRF-1 antagonist. Corticotropin-releasing factor (CRF), also known as Corticotropin-releasing hormone, is an endogenous peptide hormone released in response to various triggers such as chronic stress and drug addiction. This, then, triggers the release of corticotropin (ACTH), another hormone involved in the physiological response to stress. Chronic release of CRF and ACTH is believed to be directly or indirectly involved in many of the harmful physiological effects of chronic stress, such as excessive glucocorticoid release, stomach ulcers, anxiety, diabetes mellitus, osteoporosis, depression, and development of high blood pressure and consequent cardiovascular problems.Antalarmin is a non-peptide drug that blocks the CRF-1 receptor, and, as a consequence, reduces the release of ACTH in response to chronic stress. This has been demonstrated in animals to reduce the behavioural responses to stressful situations, and it is proposed that antalarmin itself, or more likely newer CRF antagonist drugs still under development, could be useful for reducing the adverse health consequences of chronic stress in humans, as well as having possible uses in the treatment of conditions such as anxiety, depression, and drug addiction.Results so far have had limited success, with various CRF antagonists being tested, which showed some antidepressant effects, but failed to produce an effect comparable with conventional antidepressant drugs. However more positive results were seen when antalarmin was combined with an SSRI antidepressant, suggesting a potential for synergistic effect. Encouraging results have also been observed using antalarmin as a potential treatment for anxiety and stress-induced hypertension.Chronic antalarmin treatment also showed anti-inflammatory effects and has been suggested as having potential uses in the treatment of inflammatory conditions such as arthritis, as well as stress-induced gastrointestinal ulcers and irritable bowel syndrome.Mixed results have been seen in research into the use of antalarmin and other CRF-1 antagonists in the treatment of drug addiction disorders. Tests of antalarmin on cocaine use in cocaine-addicted monkeys produced only slight reductions of use that were not statistically significant, however in tests on cocaine-addicted rats, antalarmin did prevent dose escalation with prolonged use, suggesting that it might stabilise cocaine use and prevent it increasing over time, although without consistently reducing it.Antalarmin also showed positive effects in reducing withdrawal syndrome from chronic opioid use, and significantly reduced self-administration of ethanol in ethanol-addicted rodents.".
- Antalarmin atcPrefix "none".
- Antalarmin casNumber "157284-96-3".
- Antalarmin iupacName "N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[3,2-e]pyrimidin-4-amine".
- Antalarmin pubchem "177990".
- Antalarmin thumbnail Antalarmin.svg?width=300.
- Antalarmin wikiPageExternalLink NL-Spring-05-1.shtml.
- Antalarmin wikiPageID "15803189".
- Antalarmin wikiPageLength "10013".
- Antalarmin wikiPageOutDegree "19".
- Antalarmin wikiPageRevisionID "667228087".
- Antalarmin wikiPageWikiLink Adrenocorticotropic_hormone.
- Antalarmin wikiPageWikiLink Anxiety.
- Antalarmin wikiPageWikiLink Arthritis.
- Antalarmin wikiPageWikiLink CP-154,526.
- Antalarmin wikiPageWikiLink Category:Anxiolytics.
- Antalarmin wikiPageWikiLink Category:CRF-1_antagonists.
- Antalarmin wikiPageWikiLink Category:Corticotropin-releasing_hormone.
- Antalarmin wikiPageWikiLink Category:Pyrrolopyrimidines.
- Antalarmin wikiPageWikiLink Corticotropin-releasing_hormone.
- Antalarmin wikiPageWikiLink Corticotropin-releasing_hormone_antagonist.
- Antalarmin wikiPageWikiLink Corticotropin-releasing_hormone_receptor_1.
- Antalarmin wikiPageWikiLink Depression_(mood).
- Antalarmin wikiPageWikiLink Diabetes_mellitus.
- Antalarmin wikiPageWikiLink Glucocorticoid.
- Antalarmin wikiPageWikiLink Hypertension.
- Antalarmin wikiPageWikiLink Irritable_bowel_syndrome.
- Antalarmin wikiPageWikiLink Osteoporosis.
- Antalarmin wikiPageWikiLink Peptic_ulcer.
- Antalarmin wikiPageWikiLink Pexacerfont.
- Antalarmin wikiPageWikiLinkText "Antalarmin".
- Antalarmin wikiPageWikiLinkText "antalarmin".
- Antalarmin atcPrefix "none".
- Antalarmin c "24".
- Antalarmin casNumber "157284".
- Antalarmin chembl "296641".
- Antalarmin chemspiderid "154945".
- Antalarmin h "34".
- Antalarmin iupacName "N-butyl-N-ethyl-2,5,6-trimethyl-7-pyrrolo[3,2-e]pyrimidin-4-amine".
- Antalarmin iupharLigand "3489".
- Antalarmin legalStatus "Legal".
- Antalarmin molecularWeight "378.55".
- Antalarmin n "4".
- Antalarmin pubchem "177990".
- Antalarmin smiles "n1c2ccC".
- Antalarmin stdinchi "1".
- Antalarmin stdinchikey "IXPROWGEHNVJOY-UHFFFAOYSA-N".
- Antalarmin synonyms "Antalarmin".
- Antalarmin verifiedrevid "413867276".
- Antalarmin width "180".
- Antalarmin wikiPageUsesTemplate Template:Antidepressants.
- Antalarmin wikiPageUsesTemplate Template:Anxiolytics.
- Antalarmin wikiPageUsesTemplate Template:Cascite.
- Antalarmin wikiPageUsesTemplate Template:Chemspidercite.
- Antalarmin wikiPageUsesTemplate Template:Drugbankcite.
- Antalarmin wikiPageUsesTemplate Template:Drugbox.
- Antalarmin wikiPageUsesTemplate Template:Ebicite.
- Antalarmin wikiPageUsesTemplate Template:Neuropeptide_agonists_and_antagonists.
- Antalarmin wikiPageUsesTemplate Template:Reflist.
- Antalarmin wikiPageUsesTemplate Template:Stdinchicite.
- Antalarmin subject Category:Anxiolytics.
- Antalarmin subject Category:CRF-1_antagonists.
- Antalarmin subject Category:Corticotropin-releasing_hormone.
- Antalarmin subject Category:Pyrrolopyrimidines.
- Antalarmin hypernym Drug.
- Antalarmin type ChemicalSubstance.
- Antalarmin type Drug.
- Antalarmin type Antagonist.
- Antalarmin type Drug.
- Antalarmin type Heterocycle.
- Antalarmin type Neuropeptide.
- Antalarmin type ChemicalObject.
- Antalarmin type Thing.
- Antalarmin type Q8386.
- Antalarmin comment "Antalarmin is a drug that acts as a CRF-1 antagonist. Corticotropin-releasing factor (CRF), also known as Corticotropin-releasing hormone, is an endogenous peptide hormone released in response to various triggers such as chronic stress and drug addiction. This, then, triggers the release of corticotropin (ACTH), another hormone involved in the physiological response to stress.".
- Antalarmin label "Antalarmin".
- Antalarmin sameAs Q4770927.
- Antalarmin sameAs m.03nvw01.
- Antalarmin sameAs Antalarmin.
- Antalarmin sameAs Antalarmin.
- Antalarmin sameAs Q4770927.
- Antalarmin wasDerivedFrom Antalarmin?oldid=667228087.
- Antalarmin depiction Antalarmin.svg.
- Antalarmin isPrimaryTopicOf Antalarmin.