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- Anosmin-1 abstract "Anosmin-1 is a secreted, EM associated glycoprotein found in humans and other organisms responsible for normal development, which is expressed in the brain, spinal cord and kidney. Absence or damage to the protein results in Kallmann syndrome in humans, which is characterized by loss of olfactory bulbs and GnRH secretion leading to anosmia and hypothalamic hypogonadotropic hypogonadism. Anosmin-1 is coded by the KAL-1 gene, which is found on the X chromosome. Anosmin-1 is 100 kilodaltons and is expressed on the outside of cells. Because of this and because of its contribution to normal migration of nerve cells, a role in the extracellular matrix has been postulated.During neural crest cell development, anosmin-1 plays a role in cranial neural cell formation by spatiotemporal regulation.Secreated anosmin-1 enhances FGF activity by promoting FGF8-FGFR1 complex formation, whereas inhibits both BMP5 and WNT3A activities. As a results, orchestrated regulation of FGF, BMP, and WNT by anosmin-1 control EMT and MET during neural crest cell development. In human retinal pigment epithelial cell(RPE), the expression of anosmin-1 is regulated by TGF-β which remain to be investigated.".
- Anosmin-1 wikiPageID "4950854".
- Anosmin-1 wikiPageLength "2268".
- Anosmin-1 wikiPageOutDegree "24".
- Anosmin-1 wikiPageRevisionID "667062193".
- Anosmin-1 wikiPageWikiLink Anosmia.
- Anosmin-1 wikiPageWikiLink Atomic_mass_unit.
- Anosmin-1 wikiPageWikiLink Bone_morphogenetic_protein.
- Anosmin-1 wikiPageWikiLink Category:Proteins.
- Anosmin-1 wikiPageWikiLink Epithelial–mesenchymal_transition.
- Anosmin-1 wikiPageWikiLink Extracellular_matrix.
- Anosmin-1 wikiPageWikiLink Fibroblast_growth_factor.
- Anosmin-1 wikiPageWikiLink Glycoprotein.
- Anosmin-1 wikiPageWikiLink Gonadotropin-releasing_hormone.
- Anosmin-1 wikiPageWikiLink Human.
- Anosmin-1 wikiPageWikiLink Hypogonadotropic_hypogonadism.
- Anosmin-1 wikiPageWikiLink Hypothalamus.
- Anosmin-1 wikiPageWikiLink KAL1_gene.
- Anosmin-1 wikiPageWikiLink Kallmann_syndrome.
- Anosmin-1 wikiPageWikiLink Mesenchymal–epithelial_transition.
- Anosmin-1 wikiPageWikiLink Morphogenesis.
- Anosmin-1 wikiPageWikiLink Neural_crest.
- Anosmin-1 wikiPageWikiLink Neuron.
- Anosmin-1 wikiPageWikiLink Olfactory_bulb.
- Anosmin-1 wikiPageWikiLink Organism.
- Anosmin-1 wikiPageWikiLink Transforming_growth_factor_beta.
- Anosmin-1 wikiPageWikiLink WNT3A.
- Anosmin-1 wikiPageWikiLink X_chromosome.
- Anosmin-1 wikiPageWikiLinkText "Anosmin-1".
- Anosmin-1 wikiPageWikiLinkText "anosmin-1".
- Anosmin-1 wikiPageUsesTemplate Template:Cite_journal.
- Anosmin-1 wikiPageUsesTemplate Template:Merge_to.
- Anosmin-1 wikiPageUsesTemplate Template:OMIM.
- Anosmin-1 wikiPageUsesTemplate Template:Protein-stub.
- Anosmin-1 subject Category:Proteins.
- Anosmin-1 hypernym EM.
- Anosmin-1 type Biomolecule.
- Anosmin-1 type Biomolecule.
- Anosmin-1 type Nutrient.
- Anosmin-1 comment "Anosmin-1 is a secreted, EM associated glycoprotein found in humans and other organisms responsible for normal development, which is expressed in the brain, spinal cord and kidney. Absence or damage to the protein results in Kallmann syndrome in humans, which is characterized by loss of olfactory bulbs and GnRH secretion leading to anosmia and hypothalamic hypogonadotropic hypogonadism. Anosmin-1 is coded by the KAL-1 gene, which is found on the X chromosome.".
- Anosmin-1 label "Anosmin-1".
- Anosmin-1 sameAs Q4770182.
- Anosmin-1 sameAs m.0cwr9z.
- Anosmin-1 sameAs Q4770182.
- Anosmin-1 wasDerivedFrom Anosmin-1?oldid=667062193.
- Anosmin-1 isPrimaryTopicOf Anosmin-1.