Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Amitifadine> ?p ?o }
Showing triples 1 to 87 of
87
with 100 triples per page.
- Amitifadine abstract "Amitifadine (am-i-TIF-a-deen), also known as DOV-21,947 or EB-1010, is an antidepressant drug being developed by Euthymics Bioscience Inc. It is a so-called triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).It is the (+)-enantiomer of DOV-216,303, and its (−)-enantiomer is DOV-102,677. Ki values for SERT, NET, and DAT are 99 nM, 262 nM, and 213 nM. The IC50 values for serotonin, norepinephrine and dopamine uptake are 12, 23 and 96 nM, respectivelyAmitifadine reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (MED) of 5 mg/kg. This antidepressant-like effect manifests in the absence of significant increases in motor activity at doses of up to 20 mg/kg. Amitifadine also produces a dose-dependent reduction in immobility in the tail suspension test, with an oral MED of 5 mg/kg. In microdialysis studies, amitifadine increased extracellular levels of serotonin, norepinephrine and dopamine in brain regions and did not induce hyperactivity in rats.Results in a small clinical trial indicated that amitifadine had statistically significant antidepressant effects and was well tolerated.".
- Amitifadine casNumber "410074-73-6".
- Amitifadine iupacName "(1R,5S)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane".
- Amitifadine pubchem "11658655".
- Amitifadine thumbnail Amitifadine.svg?width=300.
- Amitifadine wikiPageExternalLink euthymics-bioscience.
- Amitifadine wikiPageID "32643765".
- Amitifadine wikiPageLength "5342".
- Amitifadine wikiPageOutDegree "17".
- Amitifadine wikiPageRevisionID "705476475".
- Amitifadine wikiPageWikiLink Antidepressant.
- Amitifadine wikiPageWikiLink Behavioural_despair_test.
- Amitifadine wikiPageWikiLink Bicifadine.
- Amitifadine wikiPageWikiLink Category:Chloroarenes.
- Amitifadine wikiPageWikiLink Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- Amitifadine wikiPageWikiLink DOV-102,677.
- Amitifadine wikiPageWikiLink DOV-216,303.
- Amitifadine wikiPageWikiLink Dopamine_transporter.
- Amitifadine wikiPageWikiLink Drug.
- Amitifadine wikiPageWikiLink Enantiomer.
- Amitifadine wikiPageWikiLink GSK1360707F.
- Amitifadine wikiPageWikiLink IC50.
- Amitifadine wikiPageWikiLink Norepinephrine_transporter.
- Amitifadine wikiPageWikiLink Serotonin_transporter.
- Amitifadine wikiPageWikiLink Serotonin–norepinephrine–dopamine_reuptake_inhibitor.
- Amitifadine wikiPageWikiLink Tail_suspension_test.
- Amitifadine wikiPageWikiLink File:DOV_stereochemistry.svg.
- Amitifadine wikiPageWikiLinkText "Amitifadine".
- Amitifadine wikiPageWikiLinkText "amitifadine".
- Amitifadine c "11".
- Amitifadine casNumber "410074".
- Amitifadine chembl "592374".
- Amitifadine chemspiderid "9833390".
- Amitifadine cl "2".
- Amitifadine h "11".
- Amitifadine inchi "1".
- Amitifadine inchikey "BSMNRYCSBFHEMQ-KCJUWKMLBI".
- Amitifadine iupacName "-1".
- Amitifadine kegg "D10088".
- Amitifadine legalStatus "Investigational New Drug".
- Amitifadine molecularWeight "228.118".
- Amitifadine n "1".
- Amitifadine pubchem "11658655".
- Amitifadine smiles "C1[C@@]CC=CCl".
- Amitifadine stdinchi "1".
- Amitifadine stdinchikey "BSMNRYCSBFHEMQ-KCJUWKMLSA-N".
- Amitifadine verifiedrevid "458275864".
- Amitifadine width "200".
- Amitifadine wikiPageUsesTemplate Template:Adrenergics.
- Amitifadine wikiPageUsesTemplate Template:Antidepressants.
- Amitifadine wikiPageUsesTemplate Template:Chemspidercite.
- Amitifadine wikiPageUsesTemplate Template:Clear_left.
- Amitifadine wikiPageUsesTemplate Template:Dopaminergics.
- Amitifadine wikiPageUsesTemplate Template:Drugbankcite.
- Amitifadine wikiPageUsesTemplate Template:Drugbox.
- Amitifadine wikiPageUsesTemplate Template:Ebicite.
- Amitifadine wikiPageUsesTemplate Template:Fdacite.
- Amitifadine wikiPageUsesTemplate Template:Keggcite.
- Amitifadine wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Amitifadine wikiPageUsesTemplate Template:Reflist.
- Amitifadine wikiPageUsesTemplate Template:Respell.
- Amitifadine wikiPageUsesTemplate Template:Serotonergics.
- Amitifadine wikiPageUsesTemplate Template:Stdinchicite.
- Amitifadine subject Category:Chloroarenes.
- Amitifadine subject Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- Amitifadine hypernym Drug.
- Amitifadine type ChemicalSubstance.
- Amitifadine type Drug.
- Amitifadine type Chemical.
- Amitifadine type Drug.
- Amitifadine type Inhibitor.
- Amitifadine type Organohalide.
- Amitifadine type Organohalide.
- Amitifadine type ChemicalObject.
- Amitifadine type Thing.
- Amitifadine type Q8386.
- Amitifadine comment "Amitifadine (am-i-TIF-a-deen), also known as DOV-21,947 or EB-1010, is an antidepressant drug being developed by Euthymics Bioscience Inc. It is a so-called triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).It is the (+)-enantiomer of DOV-216,303, and its (−)-enantiomer is DOV-102,677. Ki values for SERT, NET, and DAT are 99 nM, 262 nM, and 213 nM.".
- Amitifadine label "Amitifadine".
- Amitifadine sameAs Q2843568.
- Amitifadine sameAs Amitifadine.
- Amitifadine sameAs m.05zwcmh.
- Amitifadine sameAs Amitifadin.
- Amitifadine sameAs Amitifadin.
- Amitifadine sameAs Q2843568.
- Amitifadine wasDerivedFrom Amitifadine?oldid=705476475.
- Amitifadine depiction Amitifadine.svg.
- Amitifadine isPrimaryTopicOf Amitifadine.