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- Amidase abstract "In enzymology, an amidase (EC 3.5.1.4, acylamidase, acylase (misleading), amidohydrolase (ambiguous), deaminase (ambiguous), fatty acylamidase, N-acetylaminohydrolase (ambiguous)) is an enzyme that catalyzes the hydrolysis of an amide:400pxThus, the two substrates of this enzyme are monocarboxylic acid amide and H2O, whereas its two products are monocarboxylate and NH3.This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is acylamide amidohydrolase. Other names in common use include acylamidase, acylase, amidohydrolase, deaminase, fatty acylamidase, and N-acetylaminohydrolase. This enzyme participates in 6 metabolic pathways: urea cycle and metabolism of amino groups, phenylalanine metabolism, tryptophan metabolism, cyanoamino acid metabolism, benzoate degradation via coa ligation, and styrene degradation. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence. They are widespread, being found in both prokaryotes and eukaryotes. AS enzymes catalyse the hydrolysis of amide bonds (CO-NH2), although the family has diverged widely with regard to substrate specificity and function. Nonetheless, these enzymes maintain a core alpha/beta/alpha structure, where the topologies of the N- and C-terminal halves are similar. AS enzymes characteristically have a highly conserved C-terminal region rich in serine and glycine residues, but devoid of aspartic acid and histidine residues, therefore they differ from classical serine hydrolases. These enzymes possess a unique, highly conserved Ser-Ser-Lys catalytic triad used for amide hydrolysis, although the catalytic mechanism for acyl-enzyme intermediate formation can differ between enzymes.Examples of AS signature-containing enzymes include:Peptide amidase (Pam), which catalyses the hydrolysis of the C-terminal amide bond of peptides. Fatty acid amide hydrolases, which hydrolyse fatty acid amid substrates (e.g. cannabinoid anandamide and sleep-inducing oleamide), thereby controlling the level and duration of signalling induced by this diverse class of lipid transmitters. Malonamidase E2, which catalyses the hydrolysis of malonamate into malonate and ammonia, and which is involved in the transport of fixed nitrogen from bacteroids to plant cells in symbiotic nitrogen metabolism. Subunit A of Glu-tRNA(Gln) amidotransferase,a heterotrimeric enzyme that catalyses the formation of Gln-tRNA(Gln) by the transamidation of misacylated Glu-tRNA(Gln) via amidolysis of glutamine.↑ 1.0 1.1 ↑ ↑ ↑".
- Amidase ecNumber "3.5.1.4".
- Amidase thumbnail PDB_1m22_EBI.jpg?width=300.
- Amidase wikiPageID "14501996".
- Amidase wikiPageLength "6592".
- Amidase wikiPageOutDegree "64".
- Amidase wikiPageRevisionID "701835935".
- Amidase wikiPageWikiLink Amide.
- Amidase wikiPageWikiLink Amino_acid.
- Amidase wikiPageWikiLink Ammonia.
- Amidase wikiPageWikiLink Anandamide.
- Amidase wikiPageWikiLink Aspartic_acid.
- Amidase wikiPageWikiLink Benzoate_degradation_via_coa_ligation.
- Amidase wikiPageWikiLink Biocatalysis.
- Amidase wikiPageWikiLink Biomolecular_structure.
- Amidase wikiPageWikiLink Catalysis.
- Amidase wikiPageWikiLink Catalytic_triad.
- Amidase wikiPageWikiLink Category:EC_3.5.1.
- Amidase wikiPageWikiLink Category:Enzymes_of_known_structure.
- Amidase wikiPageWikiLink Category:Protein_families.
- Amidase wikiPageWikiLink Cell_(biology).
- Amidase wikiPageWikiLink Cell_signaling.
- Amidase wikiPageWikiLink Chemical_bond.
- Amidase wikiPageWikiLink Class_(biology).
- Amidase wikiPageWikiLink Conserved_sequence.
- Amidase wikiPageWikiLink Cyanoamino_acid_metabolism.
- Amidase wikiPageWikiLink Enzyme.
- Amidase wikiPageWikiLink Eukaryote.
- Amidase wikiPageWikiLink Fatty_acid.
- Amidase wikiPageWikiLink Glutamine.
- Amidase wikiPageWikiLink Heterotrimeric.
- Amidase wikiPageWikiLink Histidine.
- Amidase wikiPageWikiLink Hydrolase.
- Amidase wikiPageWikiLink Hydrolysis.
- Amidase wikiPageWikiLink Lipid.
- Amidase wikiPageWikiLink Metabolism.
- Amidase wikiPageWikiLink Monocarboxylate.
- Amidase wikiPageWikiLink Monocarboxylic_acid_amide.
- Amidase wikiPageWikiLink Nitrogen.
- Amidase wikiPageWikiLink Nitrogen_cycle.
- Amidase wikiPageWikiLink Peptide.
- Amidase wikiPageWikiLink Phenylalanine.
- Amidase wikiPageWikiLink Plant.
- Amidase wikiPageWikiLink Product_(chemistry).
- Amidase wikiPageWikiLink Prokaryote.
- Amidase wikiPageWikiLink Protein_Data_Bank.
- Amidase wikiPageWikiLink Reaction_intermediate.
- Amidase wikiPageWikiLink Regulation_of_gene_expression.
- Amidase wikiPageWikiLink Sequence_(biology).
- Amidase wikiPageWikiLink Serine.
- Amidase wikiPageWikiLink Styrene_degradation.
- Amidase wikiPageWikiLink Substrate_(chemistry).
- Amidase wikiPageWikiLink Symbiosis.
- Amidase wikiPageWikiLink Transport.
- Amidase wikiPageWikiLink Tryptophan.
- Amidase wikiPageWikiLink Urea_cycle.
- Amidase wikiPageWikiLink Water.
- Amidase wikiPageWikiLink File:Amide_hydrolysis_Amidase.png.
- Amidase wikiPageWikiLinkText "Amidase".
- Amidase wikiPageWikiLinkText "acylase".
- Amidase wikiPageWikiLinkText "amidase".
- Amidase caption "x-ray structure of native peptide amidase from stenotrophomonas maltophilia at 1.4 a".
- Amidase casNumber "9012".
- Amidase ecNumber "3.5".
- Amidase goCode "4040".
- Amidase interpro "IPR000120".
- Amidase iubmbEcNumber "3".
- Amidase name "Amidase".
- Amidase name "amidase".
- Amidase opmFamily "72".
- Amidase opmProtein "1".
- Amidase pfam "PF01425".
- Amidase prosite "PDOC00494".
- Amidase scop "1".
- Amidase symbol "Amidase".
- Amidase wikiPageUsesTemplate Template:Carbon-nitrogen_non-peptide_hydrolases.
- Amidase wikiPageUsesTemplate Template:Cite_journal.
- Amidase wikiPageUsesTemplate Template:EC_number.
- Amidase wikiPageUsesTemplate Template:Enzyme.
- Amidase wikiPageUsesTemplate Template:Enzymes.
- Amidase wikiPageUsesTemplate Template:Hydrolase-stub.
- Amidase wikiPageUsesTemplate Template:Infobox_protein_family.
- Amidase wikiPageUsesTemplate Template:InterPro_content.
- Amidase wikiPageUsesTemplate Template:PDB_link.
- Amidase wikiPageUsesTemplate Template:Portal_bar.
- Amidase wikiPageUsesTemplate Template:Reflist.
- Amidase subject Category:EC_3.5.1.
- Amidase subject Category:Enzymes_of_known_structure.
- Amidase subject Category:Protein_families.
- Amidase hypernym Enzyme.
- Amidase type Biomolecule.
- Amidase type Enzyme.
- Amidase type Protein.
- Amidase type Chemical.
- Amidase type Thing.
- Amidase type Q206229.
- Amidase type Q8047.
- Amidase comment "In enzymology, an amidase (EC 3.5.1.4, acylamidase, acylase (misleading), amidohydrolase (ambiguous), deaminase (ambiguous), fatty acylamidase, N-acetylaminohydrolase (ambiguous)) is an enzyme that catalyzes the hydrolysis of an amide:400pxThus, the two substrates of this enzyme are monocarboxylic acid amide and H2O, whereas its two products are monocarboxylate and NH3.This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. ".
- Amidase label "Amidase".
- Amidase sameAs Q408149.