Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Ambroxol> ?p ?o }
- Ambroxol abstract "Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Mucobrox, Mucol, Lasolvan, Mucoangin, Surbronc, Ambolar, and Lysopain. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract, which play an important role in the body’s natural defence mechanisms. It stimulates synthesis and release of surfactant by type II pneumocytes. Surfactant acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents. Ambroxol is often administered as an active ingredient in cough syrup.Ambroxol is indicated as \"secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply\".There are many different formulations developed since the first marketing authorisation in 1978. Ambroxol is available as syrup, tablets, pastilles, dry powder sachets, inhalation solution, drops and ampules as well as effervescent tablets.Ambroxol also provides pain relief in acute sore throat. Pain in sore throat is the hallmark of acute pharyngitis. Sore throat is usually caused by a viral infection. The infection is self limited and the patient recovers normally after a few days. What is most bothering for the patient is the continuous pain in the throat maximized when the patient is swallowing. The main goal of treatment is thus to reduce pain. The main property of Ambroxol for treating sore throat is the local anaesthetic effect, described first in the late 1970s, but explained and confirmed in more recent work.Ambroxol is a potent inhibitor of the neuronal Na+ channels. This property led to the development of a lozenge containing 20 mg of ambroxol. Many state-of-the-art clinical studies have demonstrated the efficacy of Ambroxol in relieving pain in acute sore throat, with a rapid onset of action, with its effect lasting at least three hours. Ambroxol is also anti-inflammatory, reducing redness in a sore throat.Ambroxol has recently been shown to increase activity of the lysosomal enzyme glucocerebrosidase. Because of this it may be a useful therapeutic agent for both Gaucher disease and Parkinson's disease.It was also recently shown that Ambroxol triggers exocytosis of lysosomes by releasing calcium from acidic cellular calcium stores. This occurs by diffusion of Ambroxol into lysosomes and lysosomal pH neutralization. This mechanism is most likely responsible for the mucolytic effects of the drug, but may also explain the reported activity in Gaucher and Parkinson's disease.".
- Ambroxol atcPrefix "R05".
- Ambroxol atcSuffix "CB06".
- Ambroxol casNumber "18683-91-5".
- Ambroxol fdaUniiCode "200168S0CL".
- Ambroxol iupacName "trans-4-(2-Amino-3,5-dibrombenzylamino)-cyclohexanol".
- Ambroxol pubchem "2132".
- Ambroxol thumbnail Ambroxol_structural_formulae.png?width=300.
- Ambroxol wikiPageID "8798984".
- Ambroxol wikiPageLength "9211".
- Ambroxol wikiPageOutDegree "32".
- Ambroxol wikiPageRevisionID "707202302".
- Ambroxol wikiPageWikiLink Alveolar_cells.
- Ambroxol wikiPageWikiLink Ampoule.
- Ambroxol wikiPageWikiLink Anesthetic.
- Ambroxol wikiPageWikiLink Anti-inflammatory.
- Ambroxol wikiPageWikiLink Biosynthesis.
- Ambroxol wikiPageWikiLink Bronchus.
- Ambroxol wikiPageWikiLink Category:Alcohols.
- Ambroxol wikiPageWikiLink Category:Amines.
- Ambroxol wikiPageWikiLink Category:Anilines.
- Ambroxol wikiPageWikiLink Category:Bromoarenes.
- Ambroxol wikiPageWikiLink Category:Expectorants.
- Ambroxol wikiPageWikiLink Cough.
- Ambroxol wikiPageWikiLink Cough_medicine.
- Ambroxol wikiPageWikiLink Drug.
- Ambroxol wikiPageWikiLink Effervescent_tablet.
- Ambroxol wikiPageWikiLink Infection.
- Ambroxol wikiPageWikiLink Mucus.
- Ambroxol wikiPageWikiLink Neuron.
- Ambroxol wikiPageWikiLink Pastille.
- Ambroxol wikiPageWikiLink Pharyngitis.
- Ambroxol wikiPageWikiLink Respiratory_system.
- Ambroxol wikiPageWikiLink Respiratory_tract.
- Ambroxol wikiPageWikiLink Sachet.
- Ambroxol wikiPageWikiLink Secretomotor.
- Ambroxol wikiPageWikiLink Sodium_channel.
- Ambroxol wikiPageWikiLink Surfactant.
- Ambroxol wikiPageWikiLink Tablet_(pharmacy).
- Ambroxol wikiPageWikiLink Throat_lozenge.
- Ambroxol wikiPageWikiLink Viral_disease.
- Ambroxol wikiPageWikiLink File:Ambroxol_synthesis.png.
- Ambroxol wikiPageWikiLink File:Antbron_15mg_by_Towa_Pharmaceutical.jpg.
- Ambroxol wikiPageWikiLinkText "Ambroxol ".
- Ambroxol wikiPageWikiLinkText "Ambroxol".
- Ambroxol wikiPageWikiLinkText "ambroxol".
- Ambroxol atcPrefix "R05".
- Ambroxol atcSuffix "CB06".
- Ambroxol br "2".
- Ambroxol c "13".
- Ambroxol casNumber "18683".
- Ambroxol chembl "153479".
- Ambroxol chemspiderid "10276826".
- Ambroxol h "18".
- Ambroxol image "Ambroxol ball-and-stick.png".
- Ambroxol inchi "1".
- Ambroxol inchikey "JBDGDEWWOUBZPM-XYPYZODXBS".
- Ambroxol iupacName "trans-4--cyclohexanol".
- Ambroxol kegg "D07442".
- Ambroxol molecularWeight "378.1".
- Ambroxol n "2".
- Ambroxol o "1".
- Ambroxol pubchem "2132".
- Ambroxol smiles "O[C@H]2CC[C@H]CC2".
- Ambroxol stdinchi "1".
- Ambroxol stdinchikey "JBDGDEWWOUBZPM-XYPYZODXSA-N".
- Ambroxol unii "200168".
- Ambroxol verifiedfields "changed".
- Ambroxol verifiedrevid "464186402".
- Ambroxol wikiPageUsesTemplate Template:Cascite.
- Ambroxol wikiPageUsesTemplate Template:Chemspidercite.
- Ambroxol wikiPageUsesTemplate Template:Commons_category.
- Ambroxol wikiPageUsesTemplate Template:Cough_and_cold_preparations.
- Ambroxol wikiPageUsesTemplate Template:Drugbankcite.
- Ambroxol wikiPageUsesTemplate Template:Drugbox.
- Ambroxol wikiPageUsesTemplate Template:Drugs.com.
- Ambroxol wikiPageUsesTemplate Template:Ebicite.
- Ambroxol wikiPageUsesTemplate Template:Fdacite.
- Ambroxol wikiPageUsesTemplate Template:Keggcite.
- Ambroxol wikiPageUsesTemplate Template:Reflist.
- Ambroxol wikiPageUsesTemplate Template:Stdinchicite.
- Ambroxol subject Category:Alcohols.
- Ambroxol subject Category:Amines.
- Ambroxol subject Category:Anilines.
- Ambroxol subject Category:Bromoarenes.
- Ambroxol subject Category:Expectorants.
- Ambroxol hypernym Agent.
- Ambroxol type ChemicalSubstance.
- Ambroxol type Drug.
- Ambroxol type Group.
- Ambroxol type Alcohol.
- Ambroxol type Chemical.
- Ambroxol type Drug.
- Ambroxol type Enamine.
- Ambroxol type Group.
- Ambroxol type Organohalide.
- Ambroxol type Redirect.
- Ambroxol type Organohalide.
- Ambroxol type ChemicalObject.
- Ambroxol type Thing.