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- AlkD abstract "AlkD (Alkylpurine glycosylase D) is an enzyme belonging to a family of DNA glycosylases that are involved in DNA repair. It was discovered by a team of Norwegian biologists from Oslo in 2006. It was isolated from a soil-dwelling Gram-positive bacteria Bacillus cereus, along with another enzyme AlkC. AlkC and AlkD are most probably derived from the same protein as indicated by their close resemblance. They are also found in other prokaryotes. Among eukaryotes, they are found only in the single-celled species only, such as Entamoeba histolytica and Dictyostelium discoideum. The enzyme specifically targets 7mG (methyl-guanine) in the DNA, and is, therefore, unique among DNA glycosylases. It can also act on other methylpurines with less affinity. It indicates that the enzyme is specific for locating and cutting (excision) of chemically modified bases from DNA, exactly at 7mG, whenever there are errors in replication. It accelerates the rate of 7mG hydrolysis 100-fold over the spontaneous depurination. Thus, it protects the genome from harmful changes induced by chemical and environmental agents. Its crystal structure was described in 2008. It is the first HEAT repeat protein identified to interact with nucleic acids or to contain enzymatic activity.".
- AlkD thumbnail AlkD_recognizes_DNA.png?width=300.
- AlkD wikiPageID "48430909".
- AlkD wikiPageLength "6038".
- AlkD wikiPageOutDegree "28".
- AlkD wikiPageRevisionID "704881847".
- AlkD wikiPageWikiLink Alkylation.
- AlkD wikiPageWikiLink Amino_acid.
- AlkD wikiPageWikiLink Aromaticity.
- AlkD wikiPageWikiLink Atomic_mass_unit.
- AlkD wikiPageWikiLink Bacillus_cereus.
- AlkD wikiPageWikiLink Category:DNA_repair.
- AlkD wikiPageWikiLink Category:Hydrolases.
- AlkD wikiPageWikiLink Crystal_structure.
- AlkD wikiPageWikiLink DNA_glycosylase.
- AlkD wikiPageWikiLink DNA_repair.
- AlkD wikiPageWikiLink DNA_replication.
- AlkD wikiPageWikiLink Dictyostelium_discoideum.
- AlkD wikiPageWikiLink Entamoeba_histolytica.
- AlkD wikiPageWikiLink Enzyme.
- AlkD wikiPageWikiLink Eukaryote.
- AlkD wikiPageWikiLink Gram-positive_bacteria.
- AlkD wikiPageWikiLink Guanine.
- AlkD wikiPageWikiLink HEAT_repeat_domain.
- AlkD wikiPageWikiLink Helix.
- AlkD wikiPageWikiLink Hydrolysis.
- AlkD wikiPageWikiLink Nucleic_acid.
- AlkD wikiPageWikiLink Nucleic_acid_structure.
- AlkD wikiPageWikiLink Oslo.
- AlkD wikiPageWikiLink Prokaryote.
- AlkD wikiPageWikiLink Protozoa.
- AlkD wikiPageWikiLink File:AlkD_recognizes_DNA.png.
- AlkD wikiPageWikiLink File:AlkD_with_DNA.tif.
- AlkD wikiPageWikiLinkText "AlkD".
- AlkD wikiPageUsesTemplate Template:Reflist.
- AlkD subject Category:DNA_repair.
- AlkD subject Category:Hydrolases.
- AlkD hypernym Enzyme.
- AlkD type Protein.
- AlkD comment "AlkD (Alkylpurine glycosylase D) is an enzyme belonging to a family of DNA glycosylases that are involved in DNA repair. It was discovered by a team of Norwegian biologists from Oslo in 2006. It was isolated from a soil-dwelling Gram-positive bacteria Bacillus cereus, along with another enzyme AlkC. AlkC and AlkD are most probably derived from the same protein as indicated by their close resemblance. They are also found in other prokaryotes.".
- AlkD label "AlkD".
- AlkD sameAs Q21400335.
- AlkD sameAs AlkD.
- AlkD sameAs Q21400335.
- AlkD wasDerivedFrom AlkD?oldid=704881847.
- AlkD depiction AlkD_recognizes_DNA.png.
- AlkD isPrimaryTopicOf AlkD.