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- Alan_Fairlamb abstract "Alan Hutchison Fairlamb, CBE, FRSE, FLS, FMedSci, FSB (born 30 April 1947, Newcastle upon Tyne, England) is a Wellcome Trust Principal Research Fellow and Professor of Biochemistry in the Division of Biological Chemistry and Drug Discovery at the University of Dundee, Scotland. From 2006-2011 he was a member of the Scientific and Technical Advisory Committee of the Special Programme for Research and Training in Tropical Diseases (TDR) -- an independent global programme of scientific collaboration co-sponsored by UNICEF, UNDP, the World Bank and WHO. Currently he is a member of the governing board of the Tres Cantos Open Lab Foundation, whose aim is to accelerate the discovery and development of medicines to tackle diseases of the developing world in an open collaborative manner.Professor Alan Fairlamb, and his team study the protozoan parasites causing three different diseases - sleeping sickness, Chagas disease and leishmaniasis. He was one of the 250 scientists involved in the genome sequencing of these parasites.In 1985, Alan Fairlamb discovered a unique thiol compound present in these parasites, and named it trypanothione. This thiol metabolite is quite different from its human equivalent, glutathione. Trypanothione allows the parasites to fend off free radicals and other toxic oxidants produced by the immune system of the infected patient, and was shown to be vital for parasite survival and virulence. For instance, antimonials neutralize the Leishmania parasite’s antioxidant defence system, allowing the patient to clear the infection. Studies on the effect of drugs on trypanothione metabolism resulted in the discovery that fexinidzole is a potential oral treatment for visceral leishmaniasis.Since 2006, Alan Fairlamb and Mike Ferguson have been co-directors of the Drug Discovery Unit at the University of Dundee. The new centre, opened in 2005, has facilities for high-throughput screening and medicinal chemistry. These will take the drug discovery/development process further than any other UK university, to a stage where pharmaceutical companies will have sufficient data to move into the production stage.".
- Alan_Fairlamb birthDate "1947-04-30".
- Alan_Fairlamb birthYear "1947".
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- Alan_Fairlamb wikiPageWikiLink Academy_of_Medical_Sciences,_United_Kingdom.
- Alan_Fairlamb wikiPageWikiLink African_trypanosomiasis.
- Alan_Fairlamb wikiPageWikiLink Biochemistry.
- Alan_Fairlamb wikiPageWikiLink Category:1947_births.
- Alan_Fairlamb wikiPageWikiLink Category:Academics_of_the_University_of_Dundee.
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- Alan_Fairlamb wikiPageWikiLink Chagas_disease.
- Alan_Fairlamb wikiPageWikiLink England.
- Alan_Fairlamb wikiPageWikiLink Glutathione.
- Alan_Fairlamb wikiPageWikiLink High-throughput_screening.
- Alan_Fairlamb wikiPageWikiLink Leishmania.
- Alan_Fairlamb wikiPageWikiLink Leishmaniasis.
- Alan_Fairlamb wikiPageWikiLink Linnean_Society_of_London.
- Alan_Fairlamb wikiPageWikiLink Medicinal_chemistry.
- Alan_Fairlamb wikiPageWikiLink Newcastle_upon_Tyne.
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- Alan_Fairlamb wikiPageWikiLink Oxidizing_agent.
- Alan_Fairlamb wikiPageWikiLink Parasitism.
- Alan_Fairlamb wikiPageWikiLink Radical_(chemistry).
- Alan_Fairlamb wikiPageWikiLink Royal_Society_of_Biology.
- Alan_Fairlamb wikiPageWikiLink Royal_Society_of_Edinburgh.
- Alan_Fairlamb wikiPageWikiLink Thiol.
- Alan_Fairlamb wikiPageWikiLink Trypanothione.
- Alan_Fairlamb wikiPageWikiLink UNICEF.
- Alan_Fairlamb wikiPageWikiLink United_Nations_Development_Programme.
- Alan_Fairlamb wikiPageWikiLink University_of_Dundee.
- Alan_Fairlamb wikiPageWikiLink Wellcome_Trust.
- Alan_Fairlamb wikiPageWikiLink Whole_genome_sequencing.
- Alan_Fairlamb wikiPageWikiLink World_Bank.
- Alan_Fairlamb wikiPageWikiLink World_Health_Organization.
- Alan_Fairlamb wikiPageWikiLink File:TSH.png.
- Alan_Fairlamb wikiPageWikiLinkText "Alan Fairlamb".
- Alan_Fairlamb wikiPageWikiLinkText "Professor Alan Hutchinson Fairlamb".
- Alan_Fairlamb dateOfBirth "1947-04-30".
- Alan_Fairlamb name "Fairlamb, Alan".
- Alan_Fairlamb shortDescription "British biochemist".
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- Alan_Fairlamb description "British biochemist".
- Alan_Fairlamb description "British biochemist".
- Alan_Fairlamb subject Category:1947_births.
- Alan_Fairlamb subject Category:Academics_of_the_University_of_Dundee.
- Alan_Fairlamb subject Category:British_parasitologists.
- Alan_Fairlamb subject Category:Commanders_of_the_Order_of_the_British_Empire.
- Alan_Fairlamb subject Category:English_biochemists.
- Alan_Fairlamb subject Category:Fellows_of_the_Linnean_Society_of_London.
- Alan_Fairlamb subject Category:Fellows_of_the_Royal_Society_of_Edinburgh.
- Alan_Fairlamb subject Category:Living_people.
- Alan_Fairlamb subject Category:People_from_Newcastle_upon_Tyne.
- Alan_Fairlamb hypernym Fellow.
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- Alan_Fairlamb comment "Alan Hutchison Fairlamb, CBE, FRSE, FLS, FMedSci, FSB (born 30 April 1947, Newcastle upon Tyne, England) is a Wellcome Trust Principal Research Fellow and Professor of Biochemistry in the Division of Biological Chemistry and Drug Discovery at the University of Dundee, Scotland.".
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- Alan_Fairlamb givenName "Alan".
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- Alan_Fairlamb name "Alan Fairlamb".
- Alan_Fairlamb name "Fairlamb, Alan".
- Alan_Fairlamb surname "Fairlamb".