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- Afamelanotide abstract "Note: this article describes afamelanotide which is also known by the name melanotan I. afamelanotide should not be confused with melanotan II.Afamelanotide (/ˌæfəmɛˈlænoʊtaɪd/ (INN) (brand name Scenesse), also known as melanotan I (or melanotan-1), originally developed at the University of Arizona and now by Clinuvel Pharmaceuticals, is a synthetic peptide and analogue of the naturally occurring melanocortin peptide hormone α-melanocyte stimulating hormone (α-MSH) that has been shown to induce the production of darkening dermal pigmentation through melanogenesis and thereby subsequently reduce sun (UV) damage to UV light-exposed skin in preliminary research and human clinical trials. Its amino acid sequence is Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, and it is additionally known as [Nle4,D-Phe7]-α-MSH, which is sometimes abbreviated as NDP-MSH or NDP-α-MSH (especially in the scientific literature).Afamelanotide is the International Nonproprietary Name for the molecule [Nle4,D-Phe7]α-MSH initially researched and developed as melanotan-1 /mɛˈlænoʊtæn/ and later, CUV1647 (by Clinuvel). A marketing trade name for one brand of afamelanotide was approved in 2010 by the European Medicines Agency (EMA) Name Review Group (NRG) and the agency's Committee for Medicinal Products for Human Use (CHMP) as Scenesse (pronounced \"sen-esse\"). On May 5, 2010 the Italian Medicines Agency (AIFA, or Agenzia Italiana del Farmaco) became the first governmental health organization ever (even before the drug received approval in Europe) to authorize afamelanotide as a medicine for therapeutic treatment of Italian citizens to reduce painful dermal photosensitivity stemming from the orphan disease erythropoietic protoporphyria (EPP). This approval allowed the drug to be immediately available for prescription in Italy and reimbursable under the country's national health system. Authorities in Switzerland have also allowed prescription of the drug for EPP with reimbursement approved by two unnamed insurers. Afamelanotide is currently being trialed in the form of a \"grain of rice\"-sized bioabsorbable subcutaneous implant as a potential therapeutic photoprotection-inducing agent for a series of light-related skin indications as well as a potential dermal repigmentation agent for vitiligo. Afamelanotide, as of October 24, 2014, has been approved by the EMA in Europe for the treatment of EPP. Clinuvel now intends to seek approval of afamelanotide in the United States.Unlicensed and untested powders sold as \"melanotan\" are found on the Internet and are reported to be used by tens of thousands of members of the general public for sunless tanning. Multiple regulatory bodies have warned consumers that the peptides may be unsafe and ineffective in usage, with one regulatory agency warning that consumers who purchase any product labeled \"melanotan\" risk buying a counterfeit drug. Clinuvel Pharmaceuticals, the developer of afamelanotide, and medical researchers have warned consumers that counterfeit products sold using the names \"melanotan I and II\", could \"pose a hazard to public health\". Clinuvel has stated publicly that products sold online as \"melanotan\" are not afamelanotide.".
- Afamelanotide atcPrefix "D02".
- Afamelanotide atcSuffix "BB02".
- Afamelanotide casNumber "75921-69-6".
- Afamelanotide fdaUniiCode "QW68W3J66U".
- Afamelanotide iupacName "N-acetyl-(L)-seryl-(L)-tyrosyl-(L)-seryl-(L)-norleucyl-(L)-α-glutamyl-(L)-histidyl-(D)-phenylalanyl-(L)-arginyl-(L)-tryptophylglycyl-(L)-lysyl-(L)-prolyl-(L)-valinamide".
- Afamelanotide pubchem "16154396".
- Afamelanotide thumbnail Melanotan.png?width=300.
- Afamelanotide wikiPageExternalLink summary.cgi?sid=734258.
- Afamelanotide wikiPageExternalLink www.clinuvel.com.
- Afamelanotide wikiPageID "17981721".
- Afamelanotide wikiPageLength "47661".
- Afamelanotide wikiPageOutDegree "192".
- Afamelanotide wikiPageRevisionID "707140220".
- Afamelanotide wikiPageWikiLink ACTH_receptor.
- Afamelanotide wikiPageWikiLink Academia.
- Afamelanotide wikiPageWikiLink Actinic_keratosis.
- Afamelanotide wikiPageWikiLink Adenosine_triphosphate.
- Afamelanotide wikiPageWikiLink Adenylyl_cyclase.
- Afamelanotide wikiPageWikiLink Agonist.
- Afamelanotide wikiPageWikiLink Allele.
- Afamelanotide wikiPageWikiLink Alpha-Melanocyte-stimulating_hormone.
- Afamelanotide wikiPageWikiLink Alzheimers_disease.
- Afamelanotide wikiPageWikiLink Animal_testing.
- Afamelanotide wikiPageWikiLink Australia.
- Afamelanotide wikiPageWikiLink BMS-470,539.
- Afamelanotide wikiPageWikiLink Binding_selectivity.
- Afamelanotide wikiPageWikiLink Biological_pigment.
- Afamelanotide wikiPageWikiLink Biological_system.
- Afamelanotide wikiPageWikiLink Biomimetics.
- Afamelanotide wikiPageWikiLink Brain-derived_neurotrophic_factor.
- Afamelanotide wikiPageWikiLink Bremelanotide.
- Afamelanotide wikiPageWikiLink CREB.
- Afamelanotide wikiPageWikiLink Carcinogen.
- Afamelanotide wikiPageWikiLink Category:Melanocortin_receptor_agonists.
- Afamelanotide wikiPageWikiLink Category:Peptides.
- Afamelanotide wikiPageWikiLink Cell_(biology).
- Afamelanotide wikiPageWikiLink Clinical_trial.
- Afamelanotide wikiPageWikiLink Committee_for_Medicinal_Products_for_Human_Use.
- Afamelanotide wikiPageWikiLink Counterfeit_medications.
- Afamelanotide wikiPageWikiLink Cyclic_adenosine_monophosphate.
- Afamelanotide wikiPageWikiLink Danish_Medicines_Agency.
- Afamelanotide wikiPageWikiLink Domestic_policy.
- Afamelanotide wikiPageWikiLink Dopachrome_tautomerase.
- Afamelanotide wikiPageWikiLink Editorial.
- Afamelanotide wikiPageWikiLink Efficacy.
- Afamelanotide wikiPageWikiLink Endogeny_(biology).
- Afamelanotide wikiPageWikiLink Enzyme.
- Afamelanotide wikiPageWikiLink Epidermis.
- Afamelanotide wikiPageWikiLink Erythropoietic_protoporphyria.
- Afamelanotide wikiPageWikiLink Europe.
- Afamelanotide wikiPageWikiLink European_Medicines_Agency.
- Afamelanotide wikiPageWikiLink Export.
- Afamelanotide wikiPageWikiLink FDA_Warning_Letter.
- Afamelanotide wikiPageWikiLink Federal_Food,_Drug,_and_Cosmetic_Act.
- Afamelanotide wikiPageWikiLink Fitzpatrick_scale.
- Afamelanotide wikiPageWikiLink Food_and_Drug_Administration.
- Afamelanotide wikiPageWikiLink Gene.
- Afamelanotide wikiPageWikiLink Gunther_disease.
- Afamelanotide wikiPageWikiLink Half-life.
- Afamelanotide wikiPageWikiLink Healthcare_in_Italy.
- Afamelanotide wikiPageWikiLink Human_skin.
- Afamelanotide wikiPageWikiLink Hypothesis.
- Afamelanotide wikiPageWikiLink Import.
- Afamelanotide wikiPageWikiLink In_vitro.
- Afamelanotide wikiPageWikiLink In_vivo.
- Afamelanotide wikiPageWikiLink Indication_(medicine).
- Afamelanotide wikiPageWikiLink Injection_(medicine).
- Afamelanotide wikiPageWikiLink Insufflation_(medicine).
- Afamelanotide wikiPageWikiLink International_nonproprietary_name.
- Afamelanotide wikiPageWikiLink Intramuscular_injection.
- Afamelanotide wikiPageWikiLink Intravenous_therapy.
- Afamelanotide wikiPageWikiLink Italians.
- Afamelanotide wikiPageWikiLink Journalist.
- Afamelanotide wikiPageWikiLink Light.
- Afamelanotide wikiPageWikiLink Liverpool_John_Moores_University.
- Afamelanotide wikiPageWikiLink Malignancy.
- Afamelanotide wikiPageWikiLink Mammal.
- Afamelanotide wikiPageWikiLink Mechanism_of_action.
- Afamelanotide wikiPageWikiLink Medical_research.
- Afamelanotide wikiPageWikiLink Medicines_and_Healthcare_Products_Regulatory_Agency.
- Afamelanotide wikiPageWikiLink Melanin.
- Afamelanotide wikiPageWikiLink Melanocortin.
- Afamelanotide wikiPageWikiLink Melanocortin_1_receptor.
- Afamelanotide wikiPageWikiLink Melanocortin_3_receptor.
- Afamelanotide wikiPageWikiLink Melanocortin_4_receptor.
- Afamelanotide wikiPageWikiLink Melanocortin_5_receptor.
- Afamelanotide wikiPageWikiLink Melanocortin_receptor.
- Afamelanotide wikiPageWikiLink Melanocyte.
- Afamelanotide wikiPageWikiLink Melanocyte-stimulating_hormone.
- Afamelanotide wikiPageWikiLink Melanoma.
- Afamelanotide wikiPageWikiLink Melanotan_II.
- Afamelanotide wikiPageWikiLink Metastasis.
- Afamelanotide wikiPageWikiLink Microphthalmia-associated_transcription_factor.
- Afamelanotide wikiPageWikiLink Model_organism.
- Afamelanotide wikiPageWikiLink Modimelanotide.
- Afamelanotide wikiPageWikiLink Molecular_binding.
- Afamelanotide wikiPageWikiLink National_Cancer_Institute.
- Afamelanotide wikiPageWikiLink Natural_product.
- Afamelanotide wikiPageWikiLink Needle_exchange_programme.