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- AdipoRon abstract "AdipoRon is a selective, orally active, synthetic small-molecule agonist of the adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) (Kd = 1.8 μM and 3.1 μM, respectively). It activates AMPK and PPARα signaling and ameliorates insulin resistance, dyslipidemia, and glucose intolerance in db/db mice (an animal model for type II diabetes and obesity). Moreover, AdipoRon has been found to extend the lifespans of db/db mice fed a high-fat diet, as well as improve exercise endurance. The compound was discovered by Japanese researchers in 2013 via screening of a compound library, and is the first orally active, small-molecule agonist of the adiponectin receptors to be identified.Adiponectin receptor agonists such as AdipoRon have attracted interest as potential therapies for obesity, diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and a panoply of other conditions. In addition, adiponectin has recently been elucidated to mediate the antidepressant, anxiolytic, and neurogenic effects of physical exercise. Dysregulation of adiponectin expression has also been implicated in the pathology of mood disorders, anxiety disorders, eating disorders, neurodegenerative disorders, and various other neuropsychiatric disorders. Also, it has been determined that exercise improves insulin resistance via activation of AdipoR1. As such, adiponectin receptor agonists are a highly interesting therapeutic target for a variety of different conditions. Moreover, it has been suggested they could potentially be used as a substitute for exercise to achieve similar physical and mental health benefits.".
- AdipoRon atcPrefix "None".
- AdipoRon casNumber "924416-43-3".
- AdipoRon iupacName "2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide".
- AdipoRon pubchem "16307093".
- AdipoRon thumbnail AdipoRon.svg?width=300.
- AdipoRon wikiPageID "48816476".
- AdipoRon wikiPageLength "7231".
- AdipoRon wikiPageOutDegree "37".
- AdipoRon wikiPageRevisionID "703064690".
- AdipoRon wikiPageWikiLink AMP-activated_protein_kinase.
- AdipoRon wikiPageWikiLink Adiponectin.
- AdipoRon wikiPageWikiLink Adiponectin_receptor.
- AdipoRon wikiPageWikiLink Adiponectin_receptor_1.
- AdipoRon wikiPageWikiLink Adiponectin_receptor_2.
- AdipoRon wikiPageWikiLink Agonist.
- AdipoRon wikiPageWikiLink Antidepressant.
- AdipoRon wikiPageWikiLink Anxiety_disorder.
- AdipoRon wikiPageWikiLink Anxiolytic.
- AdipoRon wikiPageWikiLink Cardiovascular_disease.
- AdipoRon wikiPageWikiLink Category:Acetamides.
- AdipoRon wikiPageWikiLink Category:Anti-diabetic_drugs.
- AdipoRon wikiPageWikiLink Category:Antidepressants.
- AdipoRon wikiPageWikiLink Category:Antiobesity_drugs.
- AdipoRon wikiPageWikiLink Category:Piperidines.
- AdipoRon wikiPageWikiLink Category:Receptor_agonists.
- AdipoRon wikiPageWikiLink Cell_signaling.
- AdipoRon wikiPageWikiLink Diabetes_mellitus.
- AdipoRon wikiPageWikiLink Diabetes_mellitus_type_2.
- AdipoRon wikiPageWikiLink Dyslipidemia.
- AdipoRon wikiPageWikiLink Eating_disorder.
- AdipoRon wikiPageWikiLink Endurance.
- AdipoRon wikiPageWikiLink Impaired_glucose_tolerance.
- AdipoRon wikiPageWikiLink Insulin_resistance.
- AdipoRon wikiPageWikiLink Mental_disorder.
- AdipoRon wikiPageWikiLink Model_organism.
- AdipoRon wikiPageWikiLink Mood_disorder.
- AdipoRon wikiPageWikiLink Nervous_system.
- AdipoRon wikiPageWikiLink Neurodegeneration.
- AdipoRon wikiPageWikiLink Non-alcoholic_fatty_liver_disease.
- AdipoRon wikiPageWikiLink Obesity.
- AdipoRon wikiPageWikiLink Oral_administration.
- AdipoRon wikiPageWikiLink Pathology.
- AdipoRon wikiPageWikiLink Peroxisome_proliferator-activated_receptor_alpha.
- AdipoRon wikiPageWikiLink Physical_exercise.
- AdipoRon wikiPageWikiLink Small_molecule.
- AdipoRon wikiPageWikiLinkText "AdipoRon".
- AdipoRon atcPrefix "None".
- AdipoRon c "27".
- AdipoRon casNumber "924416".
- AdipoRon chemspiderid "11029953".
- AdipoRon h "28".
- AdipoRon inchi "InChI=1S/C27H28N2O3/c30-2620-32-25-13-11-232722-9-5-2-6-10-22/h1-14,24H,15-20H2,".
- AdipoRon inchikey "SHHUPGSHGSNPDB-UHFFFAOYSA-N".
- AdipoRon iupacName "2".
- AdipoRon molecularWeight "428.52282".
- AdipoRon n "2".
- AdipoRon o "3".
- AdipoRon pubchem "16307093".
- AdipoRon routesOfAdministration Oral_administration.
- AdipoRon smiles "C1CNCC4=CC=CC=C4".
- AdipoRon wikiPageUsesTemplate Template:Drugbox.
- AdipoRon wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- AdipoRon wikiPageUsesTemplate Template:Neuropeptidergics.
- AdipoRon wikiPageUsesTemplate Template:Reflist.
- AdipoRon wikiPageUsesTemplate Template:Research_help.
- AdipoRon wikiPageUsesTemplate Template:Systemic-hormonal-drug-stub.
- AdipoRon subject Category:Acetamides.
- AdipoRon subject Category:Anti-diabetic_drugs.
- AdipoRon subject Category:Antidepressants.
- AdipoRon subject Category:Antiobesity_drugs.
- AdipoRon subject Category:Piperidines.
- AdipoRon subject Category:Receptor_agonists.
- AdipoRon type ChemicalSubstance.
- AdipoRon type Drug.
- AdipoRon type ChemicalObject.
- AdipoRon type Thing.
- AdipoRon type Q8386.
- AdipoRon comment "AdipoRon is a selective, orally active, synthetic small-molecule agonist of the adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) (Kd = 1.8 μM and 3.1 μM, respectively). It activates AMPK and PPARα signaling and ameliorates insulin resistance, dyslipidemia, and glucose intolerance in db/db mice (an animal model for type II diabetes and obesity). Moreover, AdipoRon has been found to extend the lifespans of db/db mice fed a high-fat diet, as well as improve exercise endurance.".
- AdipoRon label "AdipoRon".
- AdipoRon wasDerivedFrom AdipoRon?oldid=703064690.
- AdipoRon depiction AdipoRon.svg.
- AdipoRon isPrimaryTopicOf AdipoRon.