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- Adaptive_response abstract "The adaptive response is a form of direct DNA repair in E. coli that protects DNA from damage by external agents or by errors during replication. It is initiated against alkylation, particularly methylation, of guanine or thymine nucleotides or phosphate groups on the sugar-phosphate backbone of DNA. Under sustained exposure to low-level treatment with alkylating mutagens, E. coli can adapt to the presence of the mutagen, rendering subsequent treatment with high doses of the same agent less effective.This mechanism has four related genes, also known as “SOS genes”: ada, alkA, alkB, and aidB, each one working in specific residues, all regulated by Ada protein.The adaptive response is mediated by the ada protein (a part of the Ada regulon), which covalently transfers alkyl groups from the damaged DNA to one of its two active methyl acceptor cysteine residues: Cys69 and Cys321. Ada protein can repair the damage by transferring methyl groups from O6-methylguanine or O4-methylthymine to Cys321 and also from methylphosphotriesters to Cys69 residue This process is irreversible. and it can convert the protein from a weak to a strong activator of transcription, increasing alkylating repair activity.".
- Adaptive_response wikiPageID "7360123".
- Adaptive_response wikiPageLength "4836".
- Adaptive_response wikiPageOutDegree "29".
- Adaptive_response wikiPageRevisionID "692644420".
- Adaptive_response wikiPageWikiLink AP_site.
- Adaptive_response wikiPageWikiLink Ada_(protein).
- Adaptive_response wikiPageWikiLink Ada_regulon.
- Adaptive_response wikiPageWikiLink Adenosine_deaminase.
- Adaptive_response wikiPageWikiLink AidB.
- Adaptive_response wikiPageWikiLink AlkB.
- Adaptive_response wikiPageWikiLink Alkylation.
- Adaptive_response wikiPageWikiLink Amino_acid.
- Adaptive_response wikiPageWikiLink Category:DNA_repair.
- Adaptive_response wikiPageWikiLink Category:Gene_expression.
- Adaptive_response wikiPageWikiLink Covalent_bond.
- Adaptive_response wikiPageWikiLink Cysteine.
- Adaptive_response wikiPageWikiLink DNA.
- Adaptive_response wikiPageWikiLink DNA-3-methyladenine_glycosylase_II.
- Adaptive_response wikiPageWikiLink DNA_repair.
- Adaptive_response wikiPageWikiLink Escherichia_coli.
- Adaptive_response wikiPageWikiLink Flavin_group.
- Adaptive_response wikiPageWikiLink Glycosylase.
- Adaptive_response wikiPageWikiLink Guanine.
- Adaptive_response wikiPageWikiLink Iron.
- Adaptive_response wikiPageWikiLink Methylation.
- Adaptive_response wikiPageWikiLink Mutagen.
- Adaptive_response wikiPageWikiLink Nucleotide.
- Adaptive_response wikiPageWikiLink Operon.
- Adaptive_response wikiPageWikiLink Oxidoreductase.
- Adaptive_response wikiPageWikiLink Phosphate.
- Adaptive_response wikiPageWikiLink Thymine.
- Adaptive_response wikiPageWikiLinkText "adaptive response".
- Adaptive_response wikiPageUsesTemplate Template:Cell-biology-stub.
- Adaptive_response subject Category:DNA_repair.
- Adaptive_response subject Category:Gene_expression.
- Adaptive_response hypernym Form.
- Adaptive_response type Process.
- Adaptive_response comment "The adaptive response is a form of direct DNA repair in E. coli that protects DNA from damage by external agents or by errors during replication. It is initiated against alkylation, particularly methylation, of guanine or thymine nucleotides or phosphate groups on the sugar-phosphate backbone of DNA. Under sustained exposure to low-level treatment with alkylating mutagens, E.".
- Adaptive_response label "Adaptive response".
- Adaptive_response sameAs Q4680759.
- Adaptive_response sameAs m.025_89d.
- Adaptive_response sameAs Адаптивный_ответ.
- Adaptive_response sameAs Q4680759.
- Adaptive_response wasDerivedFrom Adaptive_response?oldid=692644420.
- Adaptive_response isPrimaryTopicOf Adaptive_response.