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- Active_zone abstract "The active zone or synaptic active zone is a term first used by Couteaux and Pecot-Dechavassinein in 1970 to define the site of neurotransmitter release. Two neurons make contact through structures called synapses allowing them to communicate with each other. As shown in the diagram on the right, a synapse consists of the presynaptic bouton of one neuron which stores vesicles containing neurotransmitter (uppermost in the picture) and a second, postsynaptic neuron which bears receptors for the neurotransmitter (at the bottom). When an action potential reaches the presynaptic bouton, the contents of the vesicles are released into the synaptic cleft and the released neurotransmitter travels across the cleft to the postsynaptic neuron (the lower structure in the picture) and activates the receptors on the postsynaptic membrane.The active zone is the region in the presynaptic bouton that mediates neurotransmitter release and is composed of the presynaptic membrane and a dense collection of proteins called the cytomatrix at the active zone (CAZ). The CAZ is seen under the electron microscope to be a dark (electron dense) area close to the membrane. Proteins within the CAZ tether synaptic vesicles to the presynaptic membrane and mediate synaptic vesicle fusion, thereby allowing neurotransmitter to be released reliably and rapidly when an action potential arrives.".
- Active_zone thumbnail Neuron_synapse.png?width=300.
- Active_zone wikiPageID "31153340".
- Active_zone wikiPageLength "20490".
- Active_zone wikiPageOutDegree "69".
- Active_zone wikiPageRevisionID "663254593".
- Active_zone wikiPageWikiLink Actin.
- Active_zone wikiPageWikiLink Action_potential.
- Active_zone wikiPageWikiLink Beta-catenin.
- Active_zone wikiPageWikiLink CAMK.
- Active_zone wikiPageWikiLink CASK.
- Active_zone wikiPageWikiLink Calcineurin.
- Active_zone wikiPageWikiLink Capacitor.
- Active_zone wikiPageWikiLink Category:Cell_signaling.
- Active_zone wikiPageWikiLink Category:Cellular_neuroscience.
- Active_zone wikiPageWikiLink Category:Molecular_neuroscience.
- Active_zone wikiPageWikiLink Category:Neurobiology.
- Active_zone wikiPageWikiLink Category:Neurophysiology.
- Active_zone wikiPageWikiLink Category:Signal_transduction.
- Active_zone wikiPageWikiLink Cell_adhesion.
- Active_zone wikiPageWikiLink Chemical_synapse.
- Active_zone wikiPageWikiLink Clathrin.
- Active_zone wikiPageWikiLink Complexin.
- Active_zone wikiPageWikiLink Dephosphorylation.
- Active_zone wikiPageWikiLink Drosophila.
- Active_zone wikiPageWikiLink ERC2_(gene).
- Active_zone wikiPageWikiLink Endocytosis.
- Active_zone wikiPageWikiLink Exocytosis.
- Active_zone wikiPageWikiLink G_protein–coupled_receptor.
- Active_zone wikiPageWikiLink Glutamatergic.
- Active_zone wikiPageWikiLink Golgi_apparatus.
- Active_zone wikiPageWikiLink ITSN1.
- Active_zone wikiPageWikiLink Ligand-gated_ion_channel.
- Active_zone wikiPageWikiLink Liprin-alpha-1.
- Active_zone wikiPageWikiLink Micrograph.
- Active_zone wikiPageWikiLink Munc-18.
- Active_zone wikiPageWikiLink Myosin.
- Active_zone wikiPageWikiLink NRXN1.
- Active_zone wikiPageWikiLink Neural_facilitation.
- Active_zone wikiPageWikiLink Neuroligin.
- Active_zone wikiPageWikiLink Neuron.
- Active_zone wikiPageWikiLink Neurotransmitter.
- Active_zone wikiPageWikiLink PCLO.
- Active_zone wikiPageWikiLink Patch_clamp.
- Active_zone wikiPageWikiLink Postsynaptic_density.
- Active_zone wikiPageWikiLink Postsynaptic_potential.
- Active_zone wikiPageWikiLink RIMS1.
- Active_zone wikiPageWikiLink SNAP25.
- Active_zone wikiPageWikiLink SNARE_(protein).
- Active_zone wikiPageWikiLink Spectrin.
- Active_zone wikiPageWikiLink Synapse.
- Active_zone wikiPageWikiLink Synapsin.
- Active_zone wikiPageWikiLink Synaptic_vesicle.
- Active_zone wikiPageWikiLink Synaptotagmin_1.
- Active_zone wikiPageWikiLink Syntaxin.
- Active_zone wikiPageWikiLink Tubulin.
- Active_zone wikiPageWikiLink UNC13B.
- Active_zone wikiPageWikiLink VAMP2.
- Active_zone wikiPageWikiLink Vesicle_(biology_and_chemistry).
- Active_zone wikiPageWikiLink Vesicle_fusion.
- Active_zone wikiPageWikiLink Voltage-dependent_calcium_channel.
- Active_zone wikiPageWikiLink File:AZ_detail.png.
- Active_zone wikiPageWikiLink File:Active_zone3.JPG.
- Active_zone wikiPageWikiLink File:Exocytosis-machinery.jpg.
- Active_zone wikiPageWikiLink File:Membrane_capacitance.JPG.
- Active_zone wikiPageWikiLinkText "Active zone".
- Active_zone wikiPageWikiLinkText "Presynaptic active zone".
- Active_zone wikiPageWikiLinkText "active zone".
- Active_zone wikiPageWikiLinkText "presynaptic membrane".
- Active_zone wikiPageWikiLinkText "releasable vesicles".
- Active_zone caption "A diagram of a typical central nervous system synapse. The proteins of the active zone are represented as dark brown pyramids on the upper neuron terminal".
- Active_zone latin "zona activa".
- Active_zone name "Active zone".
- Active_zone wikiPageUsesTemplate Template:Infobox_anatomy.
- Active_zone wikiPageUsesTemplate Template:Main.
- Active_zone wikiPageUsesTemplate Template:Nervous_tissue.
- Active_zone wikiPageUsesTemplate Template:Portal.
- Active_zone wikiPageUsesTemplate Template:Reflist.
- Active_zone wikiPageUsesTemplate Template:TerminologiaHistologica.
- Active_zone wikiPageUsesTemplate Template:Vesicular_transport_proteins.
- Active_zone subject Category:Cell_signaling.
- Active_zone subject Category:Cellular_neuroscience.
- Active_zone subject Category:Molecular_neuroscience.
- Active_zone subject Category:Neurobiology.
- Active_zone subject Category:Neurophysiology.
- Active_zone subject Category:Signal_transduction.
- Active_zone hypernym Term.
- Active_zone type AnatomicalStructure.
- Active_zone type Thing.
- Active_zone type Q4936952.
- Active_zone comment "The active zone or synaptic active zone is a term first used by Couteaux and Pecot-Dechavassinein in 1970 to define the site of neurotransmitter release. Two neurons make contact through structures called synapses allowing them to communicate with each other.".
- Active_zone label "Active zone".
- Active_zone sameAs Q4677599.
- Active_zone sameAs m.0gh8x76.
- Active_zone sameAs Q4677599.
- Active_zone wasDerivedFrom Active_zone?oldid=663254593.
- Active_zone depiction Neuron_synapse.png.
- Active_zone isPrimaryTopicOf Active_zone.
- Active_zone name "Active zone".