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- Acid-sensing_ion_channel abstract "Acid-Sensing Ion Channels (ASICs) are neuronal voltage-insensitive cationic channels activated by extracellular protons. ASIC proteins are a subfamily of the ENaC/Deg superfamily of ion channels. To date six proteins of the ASIC family have been identified that arise from four genes, ASIC1, ASIC2, ASIC3, and ASIC4. ASIC1a, 1b and 2a, 2b are splice variants. ASICs are trimeric and can be made up of different combinations of subunits. ASIC2b is non functional on its own but modulates channel activity when participating in heteromultimers. ASIC4 has no known function. All ASICs are expressed in the peripheral nervous system while ASIC1a, 2a, 2b, 3 and 4 are expressed in the central nervous system. ASICs are Na+ permeable with ASIC1a showing low Ca++ permeability.The crystal structure of chicken ASIC1a was solved in 2007. The structure of ASIC1a has also served as model to understand the structure of the homologous epithelial sodium channel ENaC. In contrast to ASIC1 structure that is a homotrimer, ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ encoded by SCNN1A, SCNN1B, SCNN1G, and SCNN1D.".
- Acid-sensing_ion_channel wikiPageID "25327696".
- Acid-sensing_ion_channel wikiPageLength "5074".
- Acid-sensing_ion_channel wikiPageOutDegree "31".
- Acid-sensing_ion_channel wikiPageRevisionID "702088892".
- Acid-sensing_ion_channel wikiPageWikiLink ACCN1.
- Acid-sensing_ion_channel wikiPageWikiLink ACCN2.
- Acid-sensing_ion_channel wikiPageWikiLink ACCN3.
- Acid-sensing_ion_channel wikiPageWikiLink ACCN4.
- Acid-sensing_ion_channel wikiPageWikiLink Alternative_splicing.
- Acid-sensing_ion_channel wikiPageWikiLink Amiloride.
- Acid-sensing_ion_channel wikiPageWikiLink Analgesic.
- Acid-sensing_ion_channel wikiPageWikiLink Black_mamba.
- Acid-sensing_ion_channel wikiPageWikiLink Category:Articles_containing_video_clips.
- Acid-sensing_ion_channel wikiPageWikiLink Category:Electrophysiology.
- Acid-sensing_ion_channel wikiPageWikiLink Category:Integral_membrane_proteins.
- Acid-sensing_ion_channel wikiPageWikiLink Category:Ion_channels.
- Acid-sensing_ion_channel wikiPageWikiLink Central_nervous_system.
- Acid-sensing_ion_channel wikiPageWikiLink Epithelial_sodium_channel.
- Acid-sensing_ion_channel wikiPageWikiLink Ion_channel.
- Acid-sensing_ion_channel wikiPageWikiLink Mambalgins.
- Acid-sensing_ion_channel wikiPageWikiLink Morphine.
- Acid-sensing_ion_channel wikiPageWikiLink Nature_(journal).
- Acid-sensing_ion_channel wikiPageWikiLink Neuron.
- Acid-sensing_ion_channel wikiPageWikiLink Nociceptor.
- Acid-sensing_ion_channel wikiPageWikiLink Peptide.
- Acid-sensing_ion_channel wikiPageWikiLink Peripheral_nervous_system.
- Acid-sensing_ion_channel wikiPageWikiLink SCNN1A.
- Acid-sensing_ion_channel wikiPageWikiLink SCNN1B.
- Acid-sensing_ion_channel wikiPageWikiLink SCNN1D.
- Acid-sensing_ion_channel wikiPageWikiLink SCNN1G.
- Acid-sensing_ion_channel wikiPageWikiLink Side_effect.
- Acid-sensing_ion_channel wikiPageWikiLink Venom.
- Acid-sensing_ion_channel wikiPageWikiLink File:Inherent-Dynamics-of-the-Acid-Sensing-Ion-Channel-1-Correlates-with-the-Gating-Mechanism-pbio.1000151.s008.ogv.
- Acid-sensing_ion_channel wikiPageWikiLinkText "ASIC ionic channels".
- Acid-sensing_ion_channel wikiPageWikiLinkText "ASIC".
- Acid-sensing_ion_channel wikiPageWikiLinkText "ASIC-mediated".
- Acid-sensing_ion_channel wikiPageWikiLinkText "ASICs".
- Acid-sensing_ion_channel wikiPageWikiLinkText "Acid-sensing ion channel".
- Acid-sensing_ion_channel wikiPageWikiLinkText "acid-sensing ion channel 1 (ASIC1)".
- Acid-sensing_ion_channel wikiPageWikiLinkText "acid-sensing ion channel".
- Acid-sensing_ion_channel wikiPageUsesTemplate Template:Ion_channels.
- Acid-sensing_ion_channel wikiPageUsesTemplate Template:Molecular-cell-biology-stub.
- Acid-sensing_ion_channel wikiPageUsesTemplate Template:Reflist.
- Acid-sensing_ion_channel subject Category:Articles_containing_video_clips.
- Acid-sensing_ion_channel subject Category:Electrophysiology.
- Acid-sensing_ion_channel subject Category:Integral_membrane_proteins.
- Acid-sensing_ion_channel subject Category:Ion_channels.
- Acid-sensing_ion_channel hypernym Channels.
- Acid-sensing_ion_channel type TelevisionStation.
- Acid-sensing_ion_channel type Biophysic.
- Acid-sensing_ion_channel type Channel.
- Acid-sensing_ion_channel comment "Acid-Sensing Ion Channels (ASICs) are neuronal voltage-insensitive cationic channels activated by extracellular protons. ASIC proteins are a subfamily of the ENaC/Deg superfamily of ion channels. To date six proteins of the ASIC family have been identified that arise from four genes, ASIC1, ASIC2, ASIC3, and ASIC4. ASIC1a, 1b and 2a, 2b are splice variants. ASICs are trimeric and can be made up of different combinations of subunits.".
- Acid-sensing_ion_channel label "Acid-sensing ion channel".
- Acid-sensing_ion_channel sameAs Q4222244.
- Acid-sensing_ion_channel sameAs Récepteurs_ASIC.
- Acid-sensing_ion_channel sameAs m.09gpkf_.
- Acid-sensing_ion_channel sameAs Кислото-чувствительные_ионные_каналы.
- Acid-sensing_ion_channel sameAs Q4222244.
- Acid-sensing_ion_channel wasDerivedFrom Acid-sensing_ion_channel?oldid=702088892.
- Acid-sensing_ion_channel isPrimaryTopicOf Acid-sensing_ion_channel.