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- Abscopal_effect abstract "The abscopal effect is a phenomenon in the treatment of metastatic cancer where localized treatment of a tumor causes not only a shrinking of the treated tumor but also a shrinking of tumors in different compartments from the treated tumor. Initially associated with single-tumor, localized radiation therapy, the term has also come to encompass other types of localized treatments such as electroporation and intra-tumoral injection of therapeutics. While this phenomenon is extremely rare, its effect on the cancer can be stunning, leading to the disappearance of malignant growths throughout the entire body. Such success has been described for a variety of cancers, including melanoma, cutaneous lymphomas, and kidney cancer.Scientists are not certain how the abscopal effect works to eliminate cancer in patients. Studies in mice suggest that the effect may depend upon activation of the immune system. In a case study reported at Memorial Sloan-Kettering Cancer Center in New York City, changes in a metastatic melanoma patient’s immune system were measured over the course of treatment. The team observed changes in tumor-directed antibody levels and immune cell populations that occurred at the time of the abscopal effect. These findings support the idea that a localized treatment may broadly stimulate the immune system to fight cancer. At this time, various immune system cells, including T-cells and dendritic cells, are believed to play a primary role.Effects in tissues adjacent to the irradiated area are bystander effects and are not necessarily mediated by the same mechanisms as abscopal effects.".
- Abscopal_effect wikiPageID "35026040".
- Abscopal_effect wikiPageLength "2328".
- Abscopal_effect wikiPageOutDegree "13".
- Abscopal_effect wikiPageRevisionID "703054426".
- Abscopal_effect wikiPageWikiLink Bystander_effect_(radiobiology).
- Abscopal_effect wikiPageWikiLink Category:Cancer_treatments.
- Abscopal_effect wikiPageWikiLink Category:Medical_treatments.
- Abscopal_effect wikiPageWikiLink Dendritic_cell.
- Abscopal_effect wikiPageWikiLink Immune_system.
- Abscopal_effect wikiPageWikiLink Kidney_cancer.
- Abscopal_effect wikiPageWikiLink Lymphoma.
- Abscopal_effect wikiPageWikiLink Malignancy.
- Abscopal_effect wikiPageWikiLink Melanoma.
- Abscopal_effect wikiPageWikiLink Memorial_Sloan_Kettering_Cancer_Center.
- Abscopal_effect wikiPageWikiLink Metastasis.
- Abscopal_effect wikiPageWikiLink New_York_City.
- Abscopal_effect wikiPageWikiLink T_cell.
- Abscopal_effect wikiPageWikiLinkText "Abscopal effect".
- Abscopal_effect wikiPageWikiLinkText "abscopal effect".
- Abscopal_effect wikiPageUsesTemplate Template:Reflist.
- Abscopal_effect wikiPageUsesTemplate Template:Research_help.
- Abscopal_effect subject Category:Cancer_treatments.
- Abscopal_effect subject Category:Medical_treatments.
- Abscopal_effect hypernym Phenomenon.
- Abscopal_effect type Disease.
- Abscopal_effect comment "The abscopal effect is a phenomenon in the treatment of metastatic cancer where localized treatment of a tumor causes not only a shrinking of the treated tumor but also a shrinking of tumors in different compartments from the treated tumor. Initially associated with single-tumor, localized radiation therapy, the term has also come to encompass other types of localized treatments such as electroporation and intra-tumoral injection of therapeutics.".
- Abscopal_effect label "Abscopal effect".
- Abscopal_effect sameAs Q4669679.
- Abscopal_effect sameAs Effet_abscopal.
- Abscopal_effect sameAs m.0j62kft.
- Abscopal_effect sameAs Q4669679.
- Abscopal_effect wasDerivedFrom Abscopal_effect?oldid=703054426.
- Abscopal_effect isPrimaryTopicOf Abscopal_effect.