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- AU-rich_element abstract "Adenylate-uridylate-rich elements (AU-rich elements; AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors, and cytokines. AREs are one of the most common determinants of RNA stability in mammalian cells.AREs are defined as a region with frequent adenine and uridine bases in a mRNA. They usually target the mRNA for rapid degradation.ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines, and transcription inhibitors. These observations suggest that AREs play a critical role in the regulation of gene transcription during cell growth and differentiation, and the immune response.AREs have been divided into three classes with different sequences. The best characterised adenylate uridylate (AU)-rich Elements have a core sequence of AUUUA within Urich sequences (for example WWWU(AUUUA)UUUW where W is A or U). This lies within a 50-150 base sequence, repeats of the core AUUUA element are often required for function.A number of different proteins (e.g. HuA, HuB, HuC, HuD, HuR) bind to these elements and stabilise the mRNA while others (AUF1, TTP, BRF1, TIA-1, TIAR, and KSRP) destabilise the mRNA, miRNAs may also bind to some of them. HuD (also called ELAVL4) binds to AREs and increases the half-life of ARE-bearing mRNAs in neurons during brain development and plasticity.AREsite - a database for ARE containing genes - has recently been developed with the aim to provide detailed bioinformatic characterization of AU-rich elements.".
- AU-rich_element thumbnail Animation455.gif?width=300.
- AU-rich_element wikiPageExternalLink ARED.
- AU-rich_element wikiPageExternalLink RNAMotif?PatID=T0024.
- AU-rich_element wikiPageExternalLink AREsite.cgi.
- AU-rich_element wikiPageExternalLink RNAMotif.html.
- AU-rich_element wikiPageExternalLink abstract?uid=PII0092867486903417.
- AU-rich_element wikiPageExternalLink 852.
- AU-rich_element wikiPageID "16286691".
- AU-rich_element wikiPageLength "8727".
- AU-rich_element wikiPageOutDegree "37".
- AU-rich_element wikiPageRevisionID "668655592".
- AU-rich_element wikiPageWikiLink AREsite.
- AU-rich_element wikiPageWikiLink Adenine.
- AU-rich_element wikiPageWikiLink C-Fos.
- AU-rich_element wikiPageWikiLink C-jun.
- AU-rich_element wikiPageWikiLink CUGBP2.
- AU-rich_element wikiPageWikiLink Category:Cis-regulatory_RNA_elements.
- AU-rich_element wikiPageWikiLink Category:Gene_expression.
- AU-rich_element wikiPageWikiLink Category:RNA.
- AU-rich_element wikiPageWikiLink Cytokine.
- AU-rich_element wikiPageWikiLink ELAVL1.
- AU-rich_element wikiPageWikiLink Granulocyte_macrophage_colony-stimulating_factor.
- AU-rich_element wikiPageWikiLink HNRPD.
- AU-rich_element wikiPageWikiLink HuD_(protein).
- AU-rich_element wikiPageWikiLink Messenger_RNA.
- AU-rich_element wikiPageWikiLink MicroRNA.
- AU-rich_element wikiPageWikiLink Myc.
- AU-rich_element wikiPageWikiLink Prostaglandin.
- AU-rich_element wikiPageWikiLink Prostaglandin-endoperoxide_synthase_2.
- AU-rich_element wikiPageWikiLink Protein.
- AU-rich_element wikiPageWikiLink RNA_recognition_motif.
- AU-rich_element wikiPageWikiLink Three_prime_untranslated_region.
- AU-rich_element wikiPageWikiLink Transcription_factor.
- AU-rich_element wikiPageWikiLink Uridine.
- AU-rich_element wikiPageWikiLink File:Animation455.gif.
- AU-rich_element wikiPageWikiLinkText "AREs".
- AU-rich_element wikiPageWikiLinkText "AU-rich element".
- AU-rich_element wikiPageWikiLinkText "AU-rich elements (AREs)".
- AU-rich_element wikiPageWikiLinkText "adenylate-uridylate-rich element".
- AU-rich_element wikiPageUsesTemplate Template:Reflist.
- AU-rich_element subject Category:Cis-regulatory_RNA_elements.
- AU-rich_element subject Category:Gene_expression.
- AU-rich_element subject Category:RNA.
- AU-rich_element type Element.
- AU-rich_element type Process.
- AU-rich_element comment "Adenylate-uridylate-rich elements (AU-rich elements; AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors, and cytokines. AREs are one of the most common determinants of RNA stability in mammalian cells.AREs are defined as a region with frequent adenine and uridine bases in a mRNA.".
- AU-rich_element label "AU-rich element".
- AU-rich_element sameAs Q4654967.
- AU-rich_element sameAs Elemento_rico_en_AU.
- AU-rich_element sameAs m.03wg1nc.
- AU-rich_element sameAs ARE.
- AU-rich_element sameAs Q4654967.
- AU-rich_element wasDerivedFrom AU-rich_element?oldid=668655592.
- AU-rich_element depiction Animation455.gif.
- AU-rich_element isPrimaryTopicOf AU-rich_element.