Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/ATP-binding_cassette_transporter> ?p ?o }
- ATP-binding_cassette_transporter abstract "ATP-binding cassette transporters (ABC transporters) are members of a transport system superfamily that is one of the largest and is possibly one of the oldest families with representatives in all extant phyla from prokaryotes to humans. ABC transporter often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated ATPases. The ATPase subunits that utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to energize the translocation of various substrates across membranes, either for uptake or for export of the substrate. Most but not all uptake systems also have an extracytoplasmic receptor, a solute binding protein. Some homologous ATPases function in non-transport-related processes such as translation of RNA and DNA repair. ABC transporters are considered to be with the ABC superfamily based on the sequence and organization of their ATP-binding cassette (ABC) domains, even though the integral membrane proteins may have evolved independently several times, and thus comprise different protein families. The integral membrane proteins of ABC exporters appear to have evolved independently at least three times. ABC1 exporters evolved by intragenic triplication of a 2 TMS precursor to give 6 TMS proteins. ABC2 exporters evolved by intragenic duplication of a 3 TMS precursor, and ABC3 exporters evolved from a 4 TMS precursor which duplicated either extragenicly to give two 4 TMS proteins, both required for transport function, or intragenicly to give 8 or 10 TMS proteins. The 10 TMS proteins appear to have two extra TMSs between the two 4 TMS repeat units. Similarly, it is possible that the integral membrane proteins of ABC uptake systems evolved at least 3 times independently, based on their high resolution 3-dimensional structures. ABC uptake porters take up a large variety of nutrients, biosynthetic precursors, trace metals and vitamins, while exporters transport lipids, sterols, drugs, and a large variety of primary and secondary metabolites. Some of these exporters in humans are involved in tumor resistance, cystic fibrosis and a range of other inherited human diseases. High level expression of the genes encoding some of these exporters in both prokaryotic and eukaryotic organisms (including human) result in the development of resistance to multiple drugs such as antibiotics and anti-cancer agents.Hundreds of ABC transporters have been characterized from both prokaryotes and eukaryotes. ABC genes are essential for many processes in the cell, and mutations in human genes cause or contribute to several human genetic diseases. Forty eight ABC genes have been reported in humans. Among these, many have been of these have been characterized and shown to be causally related to diseases present in humans such as cystic fibrosis, adrenoleukodystrophy, Stargadt’s disease, drug-resistant tumors, Dubin-Johnson syndrome, Byler’s disease, progressive familiar intrahepatic cholestasis, X-linked sideroblastic anemia, ataxia, and persistent and hyperinsulimenic hypoglycemia. ABC transporters are also involved in multiple drug resistance, and this is how some of them were first identified. When the ABC transport proteins are overexpressed in cancer cells, they can export anticancer drugs and render tumors resistant.".
- ATP-binding_cassette_transporter symbol "ABC_tran".
- ATP-binding_cassette_transporter thumbnail 1l7v_opm.png?width=300.
- ATP-binding_cassette_transporter wikiPageExternalLink humanabc.htm.
- ATP-binding_cassette_transporter wikiPageExternalLink resolve?urn=urn:nbn:se:uu:diva-8371.
- ATP-binding_cassette_transporter wikiPageExternalLink www-abcdb.biotoul.fr.
- ATP-binding_cassette_transporter wikiPageExternalLink 41670.
- ATP-binding_cassette_transporter wikiPageExternalLink result.php?tc=3.A.1.9.
- ATP-binding_cassette_transporter wikiPageExternalLink index.php?tc=3.A.1.
- ATP-binding_cassette_transporter wikiPageExternalLink 7371.html.
- ATP-binding_cassette_transporter wikiPageID "1551873".
- ATP-binding_cassette_transporter wikiPageLength "105862".
- ATP-binding_cassette_transporter wikiPageOutDegree "237".
- ATP-binding_cassette_transporter wikiPageRevisionID "702274709".
- ATP-binding_cassette_transporter wikiPageWikiLink ABCA1.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCA12.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCA4.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCB11.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCB5.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCC1.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCC6.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCD1.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCE1.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCF1.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCF2.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCG1.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCG2.
- ATP-binding_cassette_transporter wikiPageWikiLink ABCdb.
- ATP-binding_cassette_transporter wikiPageWikiLink ATP-binding_cassette_transporter.
- ATP-binding_cassette_transporter wikiPageWikiLink ATP-binding_domain_of_ABC_transporters.
- ATP-binding_cassette_transporter wikiPageWikiLink ATP_hydrolysis.
- ATP-binding_cassette_transporter wikiPageWikiLink ATPase.
- ATP-binding_cassette_transporter wikiPageWikiLink ATPase_assay.
- ATP-binding_cassette_transporter wikiPageWikiLink Active_transport.
- ATP-binding_cassette_transporter wikiPageWikiLink Adenosine_diphosphate.
- ATP-binding_cassette_transporter wikiPageWikiLink Adenosine_triphosphate.
- ATP-binding_cassette_transporter wikiPageWikiLink Adrenoleukodystrophy.
- ATP-binding_cassette_transporter wikiPageWikiLink Aldosterone.
- ATP-binding_cassette_transporter wikiPageWikiLink Alpha_helix.
- ATP-binding_cassette_transporter wikiPageWikiLink Amide.
- ATP-binding_cassette_transporter wikiPageWikiLink Amino_acid.
- ATP-binding_cassette_transporter wikiPageWikiLink Annamycin.
- ATP-binding_cassette_transporter wikiPageWikiLink Antibiotics.
- ATP-binding_cassette_transporter wikiPageWikiLink Aspartic_acid.
- ATP-binding_cassette_transporter wikiPageWikiLink Ataxia.
- ATP-binding_cassette_transporter wikiPageWikiLink Auxin.
- ATP-binding_cassette_transporter wikiPageWikiLink Bacteriocin.
- ATP-binding_cassette_transporter wikiPageWikiLink Blood–brain_barrier.
- ATP-binding_cassette_transporter wikiPageWikiLink Calcein.
- ATP-binding_cassette_transporter wikiPageWikiLink Catalysis.
- ATP-binding_cassette_transporter wikiPageWikiLink Category:ABC_transporters.
- ATP-binding_cassette_transporter wikiPageWikiLink Category:Protein_families.
- ATP-binding_cassette_transporter wikiPageWikiLink Cell_membrane.
- ATP-binding_cassette_transporter wikiPageWikiLink Chemotherapy.
- ATP-binding_cassette_transporter wikiPageWikiLink Cholestasis.
- ATP-binding_cassette_transporter wikiPageWikiLink Cholesterol.
- ATP-binding_cassette_transporter wikiPageWikiLink Chromosomal_translocation.
- ATP-binding_cassette_transporter wikiPageWikiLink Chromosome.
- ATP-binding_cassette_transporter wikiPageWikiLink Corneal_dystrophy.
- ATP-binding_cassette_transporter wikiPageWikiLink Cortisol.
- ATP-binding_cassette_transporter wikiPageWikiLink Cross-link.
- ATP-binding_cassette_transporter wikiPageWikiLink Cyclophosphamide.
- ATP-binding_cassette_transporter wikiPageWikiLink Cystic_fibrosis.
- ATP-binding_cassette_transporter wikiPageWikiLink Cystic_fibrosis_transmembrane_conductance_regulator.
- ATP-binding_cassette_transporter wikiPageWikiLink Cytochrome.
- ATP-binding_cassette_transporter wikiPageWikiLink Cytoplasm.
- ATP-binding_cassette_transporter wikiPageWikiLink Dendrite.
- ATP-binding_cassette_transporter wikiPageWikiLink Dexamethasone.
- ATP-binding_cassette_transporter wikiPageWikiLink Diazoxide.
- ATP-binding_cassette_transporter wikiPageWikiLink Doxorubicin.
- ATP-binding_cassette_transporter wikiPageWikiLink Drosophila_melanogaster.
- ATP-binding_cassette_transporter wikiPageWikiLink Drug.
- ATP-binding_cassette_transporter wikiPageWikiLink Drug_interaction.
- ATP-binding_cassette_transporter wikiPageWikiLink Dubin–Johnson_syndrome.
- ATP-binding_cassette_transporter wikiPageWikiLink Electron_crystallography.
- ATP-binding_cassette_transporter wikiPageWikiLink Electron_paramagnetic_resonance.
- ATP-binding_cassette_transporter wikiPageWikiLink Enterobactin.
- ATP-binding_cassette_transporter wikiPageWikiLink Eukaryote.
- ATP-binding_cassette_transporter wikiPageWikiLink Extracellular_fluid.
- ATP-binding_cassette_transporter wikiPageWikiLink Fatty_acid_metabolism.
- ATP-binding_cassette_transporter wikiPageWikiLink Flippase.
- ATP-binding_cassette_transporter wikiPageWikiLink Fluorescence.
- ATP-binding_cassette_transporter wikiPageWikiLink Fluorouracil.
- ATP-binding_cassette_transporter wikiPageWikiLink Galactose.
- ATP-binding_cassette_transporter wikiPageWikiLink Gene.
- ATP-binding_cassette_transporter wikiPageWikiLink Gene_cassette.
- ATP-binding_cassette_transporter wikiPageWikiLink Glucocerebroside.
- ATP-binding_cassette_transporter wikiPageWikiLink Glucose.
- ATP-binding_cassette_transporter wikiPageWikiLink Glutamic_acid.
- ATP-binding_cassette_transporter wikiPageWikiLink Glutamine.
- ATP-binding_cassette_transporter wikiPageWikiLink Glycine.
- ATP-binding_cassette_transporter wikiPageWikiLink Gram-negative_bacteria.
- ATP-binding_cassette_transporter wikiPageWikiLink Gram-positive_bacteria.
- ATP-binding_cassette_transporter wikiPageWikiLink HeLa.
- ATP-binding_cassette_transporter wikiPageWikiLink Heme.
- ATP-binding_cassette_transporter wikiPageWikiLink Hemolysin.
- ATP-binding_cassette_transporter wikiPageWikiLink Hemolysis.
- ATP-binding_cassette_transporter wikiPageWikiLink Histidine.
- ATP-binding_cassette_transporter wikiPageWikiLink Hydrolase.
- ATP-binding_cassette_transporter wikiPageWikiLink Hydrolysis.