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- AT-076 abstract "AT-076 is a so-called opioid \"pan\" antagonist and is the first reasonably balanced antagonist known of all four opioid receptor types. It acts as a silent antagonist of all four of the opioid receptors, behaving as a competitive antagonist of the μ-opioid receptor (Ki = 1.67 nM) and δ-opioid receptor (Ki = 19.6 nM) and as a noncompetitive antagonist of the κ-opioid receptor (Ki = 1.14 nM) and nociceptin receptor (Ki = 1.75 nM). AT-076 was derived from the selective κ-opioid receptor antagonist JDTic via removal of the 3,4-dimethyl group of the trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine antagonist scaffold, which increased affinity for the nociceptin receptor by 10-fold and for the μ- and δ-opioid receptors by 3-6-fold.".
- AT-076 iupacName "(3R)-7-hydroxy-N-[(2S)-1-[4-(3-hydroxyphenyl)piperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide".
- AT-076 thumbnail AT-076_structure.png?width=300.
- AT-076 wikiPageID "46401622".
- AT-076 wikiPageLength "2931".
- AT-076 wikiPageOutDegree "23".
- AT-076 wikiPageRevisionID "696163182".
- AT-076 wikiPageWikiLink BU09059.
- AT-076 wikiPageWikiLink Buprenorphine.
- AT-076 wikiPageWikiLink Category:Carboxamides.
- AT-076 wikiPageWikiLink Category:Kappa_antagonists.
- AT-076 wikiPageWikiLink Category:Nociceptin_receptor_antagonists.
- AT-076 wikiPageWikiLink Category:Opioid_antagonists.
- AT-076 wikiPageWikiLink Category:Phenols.
- AT-076 wikiPageWikiLink Category:Piperidines.
- AT-076 wikiPageWikiLink Category:Synthetic_opioids.
- AT-076 wikiPageWikiLink Category:Tetrahydroisoquinolines.
- AT-076 wikiPageWikiLink Cebranopadol.
- AT-076 wikiPageWikiLink Competitive_antagonist.
- AT-076 wikiPageWikiLink JDTic.
- AT-076 wikiPageWikiLink Ligand_(biochemistry).
- AT-076 wikiPageWikiLink Nociceptin_receptor.
- AT-076 wikiPageWikiLink Opioid_antagonist.
- AT-076 wikiPageWikiLink Opioid_receptor.
- AT-076 wikiPageWikiLink Receptor_antagonist.
- AT-076 wikiPageWikiLink Δ-opioid_receptor.
- AT-076 wikiPageWikiLink Κ-opioid_receptor.
- AT-076 wikiPageWikiLink Μ-opioid_receptor.
- AT-076 wikiPageWikiLinkText "AT-076".
- AT-076 c "26".
- AT-076 h "35".
- AT-076 iupacName "-7".
- AT-076 molecularWeight "437.573".
- AT-076 n "3".
- AT-076 o "3".
- AT-076 smiles "C4c1ccccc1CNC4CNCCNCCC3ccc2O".
- AT-076 wikiPageUsesTemplate Template:Drugbox.
- AT-076 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- AT-076 wikiPageUsesTemplate Template:Opioidergics.
- AT-076 wikiPageUsesTemplate Template:Reflist.
- AT-076 subject Category:Carboxamides.
- AT-076 subject Category:Kappa_antagonists.
- AT-076 subject Category:Nociceptin_receptor_antagonists.
- AT-076 subject Category:Opioid_antagonists.
- AT-076 subject Category:Phenols.
- AT-076 subject Category:Piperidines.
- AT-076 subject Category:Synthetic_opioids.
- AT-076 subject Category:Tetrahydroisoquinolines.
- AT-076 hypernym Opioid.
- AT-076 type ChemicalSubstance.
- AT-076 type Drug.
- AT-076 type ChemicalObject.
- AT-076 type Thing.
- AT-076 type Q8386.
- AT-076 comment "AT-076 is a so-called opioid \"pan\" antagonist and is the first reasonably balanced antagonist known of all four opioid receptor types. It acts as a silent antagonist of all four of the opioid receptors, behaving as a competitive antagonist of the μ-opioid receptor (Ki = 1.67 nM) and δ-opioid receptor (Ki = 19.6 nM) and as a noncompetitive antagonist of the κ-opioid receptor (Ki = 1.14 nM) and nociceptin receptor (Ki = 1.75 nM).".
- AT-076 label "AT-076".
- AT-076 sameAs Q19903375.
- AT-076 sameAs m.0134891x.
- AT-076 sameAs Q19903375.
- AT-076 wasDerivedFrom AT-076?oldid=696163182.
- AT-076 depiction AT-076_structure.png.
- AT-076 isPrimaryTopicOf AT-076.