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- ASD_(database) abstract "Allostery is the most direct and efficient way for regulation of biological macromolecule function induced by the binding of a ligand at an allosteric site topographically distinct from the orthosteric site. Due to the inherent high receptor selectivity and lower target-based toxicity, it is also expected to play a more positive role in drug discovery and bioengineering, leading to rapid growth on allosteric findings.Allosteric Database (ASD) provides a central resource for the display, search and analysis of the structure, function and related annotation for allosteric molecules. Currently, ASD contains allosteric proteins from more than 100 species and modulators in three categories (activators, inhibitors, and regulators). Each protein is annotated with a detailed description of allostery, biological process and related diseases, and each modulator with binding affinity, physicochemical properties and therapeutic area. Integrating the information of allosteric proteins in ASD should allow for the prediction of allostery for unknown proteins and eventually make them ideal targets for experimental validation. In addition, modulators curated in ASD can be used to investigate potent allosteric targets for the query compound, and also help chemists implement structure modifications for novel allosteric drug designs. Therefore, ASD could be a platform and a starting point for biologists and medicinal chemists for furthering allosteric research.".
- ASD_(database) thumbnail Database.png?width=300.
- ASD_(database) title "AlloSteric Database".
- ASD_(database) wikiPageExternalLink ASD.
- ASD_(database) wikiPageID "30351926".
- ASD_(database) wikiPageLength "3155".
- ASD_(database) wikiPageOutDegree "14".
- ASD_(database) wikiPageRevisionID "674417876".
- ASD_(database) wikiPageWikiLink Allosteric_regulation.
- ASD_(database) wikiPageWikiLink Binding_selectivity.
- ASD_(database) wikiPageWikiLink Biochemistry.
- ASD_(database) wikiPageWikiLink Biological_engineering.
- ASD_(database) wikiPageWikiLink Category:Biological_databases.
- ASD_(database) wikiPageWikiLink Category:Enzyme_kinetics.
- ASD_(database) wikiPageWikiLink Category:Proteins.
- ASD_(database) wikiPageWikiLink Dissociation_constant.
- ASD_(database) wikiPageWikiLink Ligand_(biochemistry).
- ASD_(database) wikiPageWikiLink Macromolecule.
- ASD_(database) wikiPageWikiLink File:Database.png.
- ASD_(database) wikiPageWikiLinkText "ASD (database)".
- ASD_(database) wikiPageWikiLinkText "ASD database".
- ASD_(database) center "Shanghai Jiao Tong University School of Medicine".
- ASD_(database) description "ASD: a comprehensive database of allosteric proteins and modulators.".
- ASD_(database) laboratory "Molecular Design Laboratory, Department of Pathophysiology".
- ASD_(database) logo File:Database.png.
- ASD_(database) pmid "PMID 21051350".
- ASD_(database) released "2012".
- ASD_(database) title "AlloSteric Database".
- ASD_(database) url ASD.
- ASD_(database) wikiPageUsesTemplate Template:Biodatabase-stub.
- ASD_(database) wikiPageUsesTemplate Template:Infobox_biodatabase.
- ASD_(database) wikiPageUsesTemplate Template:Reflist.
- ASD_(database) description "ASD: a comprehensive database of allosteric proteins and modulators.".
- ASD_(database) subject Category:Biological_databases.
- ASD_(database) subject Category:Enzyme_kinetics.
- ASD_(database) subject Category:Proteins.
- ASD_(database) type BiologicalDatabase.
- ASD_(database) type Biomolecule.
- ASD_(database) type Database.
- ASD_(database) type Work.
- ASD_(database) type Biomolecule.
- ASD_(database) type Nutrient.
- ASD_(database) type CreativeWork.
- ASD_(database) type InformationObject.
- ASD_(database) type Thing.
- ASD_(database) type Q386724.
- ASD_(database) comment "Allostery is the most direct and efficient way for regulation of biological macromolecule function induced by the binding of a ligand at an allosteric site topographically distinct from the orthosteric site.".
- ASD_(database) label "ASD (database)".
- ASD_(database) sameAs Q4654160.
- ASD_(database) sameAs m.0g5rft1.
- ASD_(database) sameAs Q4654160.
- ASD_(database) wasDerivedFrom ASD_(database)?oldid=674417876.
- ASD_(database) depiction Database.png.
- ASD_(database) homepage ASD.
- ASD_(database) isPrimaryTopicOf ASD_(database).