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- ALPL abstract "Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene.There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue-nonspecific). The first three are located together on chromosome 2, whereas the tissue-nonspecific form is located on chromosome 1. The product of this gene is a membrane-bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization. However, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation, since this determines age of onset and severity of symptoms.".
- ALPL entrezgene "249".
- ALPL wikiPageExternalLink br.fcgi?book=gene&part=hops.
- ALPL wikiPageID "14297479".
- ALPL wikiPageLength "8688".
- ALPL wikiPageOutDegree "4".
- ALPL wikiPageRevisionID "659775405".
- ALPL wikiPageWikiLink Alkaline_phosphatase.
- ALPL wikiPageWikiLink Enzyme.
- ALPL wikiPageWikiLink Gene.
- ALPL wikiPageWikiLink Hypophosphatasia.
- ALPL wikiPageWikiLinkText "ALPL".
- ALPL wikiPageWikiLinkText "Tissue non-specific alkaline phosphatase".
- ALPL requireManualInspection "no".
- ALPL summaryText "There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney . The first three are located together on chromosome 2, whereas the tissue-nonspecific form is located on chromosome 1. The product of this gene is a membrane-bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization. However, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation, since this determines age of onset and severity of symptoms.".
- ALPL updateCitations "yes".
- ALPL updatePage "yes".
- ALPL updateProteinBox "yes".
- ALPL updateSummary "yes".
- ALPL wikiPageUsesTemplate Template:Cite_journal.
- ALPL wikiPageUsesTemplate Template:Esterases.
- ALPL wikiPageUsesTemplate Template:PBB.
- ALPL wikiPageUsesTemplate Template:PBB_Controls.
- ALPL wikiPageUsesTemplate Template:PBB_Further_reading.
- ALPL wikiPageUsesTemplate Template:PBB_Summary.
- ALPL wikiPageUsesTemplate Template:Refbegin.
- ALPL wikiPageUsesTemplate Template:Refend.
- ALPL wikiPageUsesTemplate Template:Reflist.
- ALPL hypernym Enzyme.
- ALPL type Biomolecule.
- ALPL type Protein.
- ALPL type Thing.
- ALPL type Q206229.
- ALPL type Q8054.
- ALPL comment "Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene.There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue-nonspecific). The first three are located together on chromosome 2, whereas the tissue-nonspecific form is located on chromosome 1.".
- ALPL label "ALPL".
- ALPL sameAs Q17825104.
- ALPL sameAs m.03c_rq5.
- ALPL sameAs Q17825104.
- ALPL wasDerivedFrom ALPL?oldid=659775405.
- ALPL isPrimaryTopicOf ALPL.