Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/ALAD> ?p ?o }
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- ALAD entrezgene "210".
- ALAD wikiPageID "14167645".
- ALAD wikiPageLength "8401".
- ALAD wikiPageOutDegree "10".
- ALAD wikiPageRevisionID "691897118".
- ALAD wikiPageWikiLink Anemia.
- ALAD wikiPageWikiLink Enzyme.
- ALAD wikiPageWikiLink Erythropoietin.
- ALAD wikiPageWikiLink Gene.
- ALAD wikiPageWikiLink Heme.
- ALAD wikiPageWikiLink Lead.
- ALAD wikiPageWikiLink Porphyria.
- ALAD wikiPageWikiLink Porphyrin.
- ALAD wikiPageWikiLink Red_blood_cell.
- ALAD wikiPageWikiLink Robert_J._Desnick.
- ALAD wikiPageWikiLinkText "ALAD".
- ALAD wikiPageWikiLinkText "Delta-aminolevulinic acid dehydratase".
- ALAD requireManualInspection "no".
- ALAD summaryText "The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen . ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead, beginning at blood lead levels that were once considered to be safe and continuing to correlate negatively across the range from 5 to 95 μg/dL. Inhibition of ALAD by lead leads to anemia primarily because it both inhibits heme synthesis and shortenis the lifespan of circulating red blood cells, but also by stimulating the excessive production of the hormone erythropoietin, leading to inadequate maturation of red cells from their progenitors. A defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternatively spliced transcript variants encoding different isoforms have been identified.".
- ALAD updateCitations "yes".
- ALAD updatePage "yes".
- ALAD updateProteinBox "yes".
- ALAD updateSummary "yes".
- ALAD wikiPageUsesTemplate Template:Cite_journal.
- ALAD wikiPageUsesTemplate Template:Gene-9-stub.
- ALAD wikiPageUsesTemplate Template:PBB.
- ALAD wikiPageUsesTemplate Template:PBB_Controls.
- ALAD wikiPageUsesTemplate Template:PBB_Further_reading.
- ALAD wikiPageUsesTemplate Template:PBB_Summary.
- ALAD wikiPageUsesTemplate Template:PDB_Gallery.
- ALAD wikiPageUsesTemplate Template:Refbegin.
- ALAD wikiPageUsesTemplate Template:Refend.
- ALAD wikiPageUsesTemplate Template:Reflist.
- ALAD hypernym Enzyme.
- ALAD type Biomolecule.
- ALAD type Protein.
- ALAD type Thing.
- ALAD type Q206229.
- ALAD type Q8054.
- ALAD comment "Delta-aminolevulinic acid dehydratase is an enzyme that in humans is encoded by the ALAD gene.The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity.".
- ALAD label "ALAD".
- ALAD sameAs Q17816567.
- ALAD sameAs 5-amminolevulinato_deidratasi.
- ALAD sameAs m.03cwnzl.
- ALAD sameAs Q17816567.
- ALAD wasDerivedFrom ALAD?oldid=691897118.
- ALAD isPrimaryTopicOf ALAD.