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- ADX-71149 abstract "ADX-71149, also known as JNJ-4041183 and JNJ-mGluR2-PAM, is a selective positive allosteric modulator of the mGlu2 receptor. It is being studied by Addex Therapeutics and Janssen Pharmaceuticals for the treatment of schizophrenia. It was also researched by these companies for the treatment of anxious depression (major depressive disorder with anxiety symptoms), but although some efficacy was observed in clinical trials, it was not enough to warrant further development for this indication. As of 2015, ADX-71149 is in phase II clinical trials for schizophrenia.".
- ADX-71149 atcPrefix "None".
- ADX-71149 casNumber "879891-35-7".
- ADX-71149 iupacName "1-[(4-Chloro-2-fluorophenyl)methyl]-5-(4-methoxyphenyl)pyridin-2-one".
- ADX-71149 pubchem "11523023".
- ADX-71149 thumbnail ADX-71149.svg?width=300.
- ADX-71149 wikiPageExternalLink 800030424.
- ADX-71149 wikiPageExternalLink adx71149-for-anxiety.
- ADX-71149 wikiPageExternalLink adx71149-for-schizophrenia.
- ADX-71149 wikiPageID "46790356".
- ADX-71149 wikiPageLength "6005".
- ADX-71149 wikiPageOutDegree "21".
- ADX-71149 wikiPageRevisionID "695420745".
- ADX-71149 wikiPageWikiLink Addex_Therapeutics.
- ADX-71149 wikiPageWikiLink Allosteric_modulator.
- ADX-71149 wikiPageWikiLink Anxiety.
- ADX-71149 wikiPageWikiLink Biphenylindanone_A.
- ADX-71149 wikiPageWikiLink Category:Chloroarenes.
- ADX-71149 wikiPageWikiLink Category:Fluoroarenes.
- ADX-71149 wikiPageWikiLink Category:Ketones.
- ADX-71149 wikiPageWikiLink Category:MGlu5_receptor_antagonists.
- ADX-71149 wikiPageWikiLink Category:Pyridines.
- ADX-71149 wikiPageWikiLink Clinical_trial.
- ADX-71149 wikiPageWikiLink Eglumegad.
- ADX-71149 wikiPageWikiLink Janssen_Pharmaceutica.
- ADX-71149 wikiPageWikiLink LY-379,268.
- ADX-71149 wikiPageWikiLink LY-404,039.
- ADX-71149 wikiPageWikiLink LY-487,379.
- ADX-71149 wikiPageWikiLink Major_depressive_disorder.
- ADX-71149 wikiPageWikiLink Metabotropic_glutamate_receptor_2.
- ADX-71149 wikiPageWikiLink Mixed_anxiety-depressive_disorder.
- ADX-71149 wikiPageWikiLink Phases_of_clinical_research.
- ADX-71149 wikiPageWikiLink Schizophrenia.
- ADX-71149 wikiPageWikiLinkText "ADX-71149".
- ADX-71149 atcPrefix "None".
- ADX-71149 c "19".
- ADX-71149 casNumber "879891".
- ADX-71149 chemspiderid "9697810".
- ADX-71149 cl "1".
- ADX-71149 f "1".
- ADX-71149 h "15".
- ADX-71149 inchi "InChI=1S/C19H15ClFNO2/c1-24-17-7-3-1314-5-9-192212-15-2-6-1610-1821/h2-11H,12H2,1H3".
- ADX-71149 inchikey "VLTLVMNNIVBONY-UHFFFAOYSA-N".
- ADX-71149 iupacName "1".
- ADX-71149 molecularWeight "343.779".
- ADX-71149 n "1".
- ADX-71149 o "2".
- ADX-71149 pubchem "11523023".
- ADX-71149 smiles "COC1=CC=CC2=CNCC3=CF".
- ADX-71149 width "200".
- ADX-71149 wikiPageUsesTemplate Template:Drugbox.
- ADX-71149 wikiPageUsesTemplate Template:Glutamatergics.
- ADX-71149 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- ADX-71149 wikiPageUsesTemplate Template:Reflist.
- ADX-71149 subject Category:Chloroarenes.
- ADX-71149 subject Category:Fluoroarenes.
- ADX-71149 subject Category:Ketones.
- ADX-71149 subject Category:MGlu5_receptor_antagonists.
- ADX-71149 subject Category:Pyridines.
- ADX-71149 hypernym Modulator.
- ADX-71149 type ChemicalSubstance.
- ADX-71149 type Drug.
- ADX-71149 type ChemicalObject.
- ADX-71149 type Thing.
- ADX-71149 type Q8386.
- ADX-71149 comment "ADX-71149, also known as JNJ-4041183 and JNJ-mGluR2-PAM, is a selective positive allosteric modulator of the mGlu2 receptor. It is being studied by Addex Therapeutics and Janssen Pharmaceuticals for the treatment of schizophrenia. It was also researched by these companies for the treatment of anxious depression (major depressive disorder with anxiety symptoms), but although some efficacy was observed in clinical trials, it was not enough to warrant further development for this indication.".
- ADX-71149 label "ADX-71149".
- ADX-71149 sameAs Q20707348.
- ADX-71149 sameAs m.0139v007.
- ADX-71149 sameAs Q20707348.
- ADX-71149 wasDerivedFrom ADX-71149?oldid=695420745.
- ADX-71149 depiction ADX-71149.svg.
- ADX-71149 isPrimaryTopicOf ADX-71149.