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- ADH-1 abstract "ADH-1 (brand name Exherin) is a small, cyclic pentapeptide vascular-targeting drug.ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell–cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels.In a pilot study (phase I trial) at Duke Comprehensive Cancer Center, ADH-1 intravenous pretreatment before chemotherapy in metastatic melanoma completely destroyed tumors in half the patients, normally a very deadly cancer. It is being investigated for advanced extremity melanoma in phase II trials.".
- ADH-1 thumbnail ADH-1.svg?width=300.
- ADH-1 wikiPageID "21852860".
- ADH-1 wikiPageLength "3794".
- ADH-1 wikiPageOutDegree "14".
- ADH-1 wikiPageRevisionID "681497753".
- ADH-1 wikiPageWikiLink Apoptosis.
- ADH-1 wikiPageWikiLink CDH2.
- ADH-1 wikiPageWikiLink Cadherin.
- ADH-1 wikiPageWikiLink Category:Cyclic_peptides.
- ADH-1 wikiPageWikiLink Category:Experimental_cancer_drugs.
- ADH-1 wikiPageWikiLink Cell_adhesion.
- ADH-1 wikiPageWikiLink Chemotherapy.
- ADH-1 wikiPageWikiLink Duke.
- ADH-1 wikiPageWikiLink Melanoma.
- ADH-1 wikiPageWikiLink NCI-designated_Cancer_Center.
- ADH-1 wikiPageWikiLink Pericyte.
- ADH-1 wikiPageWikiLink Phases_of_clinical_research.
- ADH-1 wikiPageWikiLinkText "ADH-1".
- ADH-1 atcPrefix "none".
- ADH-1 c "22".
- ADH-1 casNumber "229971".
- ADH-1 chemspiderid "8091706".
- ADH-1 h "34".
- ADH-1 inchi "1".
- ADH-1 inchikey "FQVLRGLGWNWPSS-BXBUPLCLBT".
- ADH-1 molecularWeight "570.69".
- ADH-1 n "8".
- ADH-1 o "6".
- ADH-1 pubchem "9916058".
- ADH-1 s "2".
- ADH-1 smiles "O=CC".
- ADH-1 stdinchi "1".
- ADH-1 stdinchikey "FQVLRGLGWNWPSS-BXBUPLCLSA-N".
- ADH-1 tradename "Exherin".
- ADH-1 wikiPageUsesTemplate Template:About.
- ADH-1 wikiPageUsesTemplate Template:Antineoplastic-drug-stub.
- ADH-1 wikiPageUsesTemplate Template:Infobox_drug.
- ADH-1 wikiPageUsesTemplate Template:Orphan.
- ADH-1 wikiPageUsesTemplate Template:Reflist.
- ADH-1 subject Category:Cyclic_peptides.
- ADH-1 subject Category:Experimental_cancer_drugs.
- ADH-1 type ChemicalSubstance.
- ADH-1 type Drug.
- ADH-1 type Drug.
- ADH-1 type ChemicalObject.
- ADH-1 type Thing.
- ADH-1 type Q8386.
- ADH-1 comment "ADH-1 (brand name Exherin) is a small, cyclic pentapeptide vascular-targeting drug.ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.".
- ADH-1 label "ADH-1".
- ADH-1 sameAs Q4651113.
- ADH-1 sameAs m.05p4pfq.
- ADH-1 sameAs Q4651113.
- ADH-1 wasDerivedFrom ADH-1?oldid=681497753.
- ADH-1 depiction ADH-1.svg.
- ADH-1 isPrimaryTopicOf ADH-1.