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- ADD3 abstract "Gamma-adducin is a protein that in humans is encoded by the ADD3 gene.Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is composed of two distinct domains. The amino-terminal region is protease-resistant and globular in shape, while the carboxy-terminal region is protease-sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.".
- ADD3 entrezgene "120".
- ADD3 wikiPageID "14879738".
- ADD3 wikiPageLength "6358".
- ADD3 wikiPageOutDegree "26".
- ADD3 wikiPageRevisionID "659774385".
- ADD3 wikiPageWikiLink Actin.
- ADD3 wikiPageWikiLink Adducin.
- ADD3 wikiPageWikiLink C-terminus.
- ADD3 wikiPageWikiLink Calmodulin.
- ADD3 wikiPageWikiLink Cell-cell_contact.
- ADD3 wikiPageWikiLink Epithelium.
- ADD3 wikiPageWikiLink Gene.
- ADD3 wikiPageWikiLink Globular_cluster.
- ADD3 wikiPageWikiLink Haematopoiesis.
- ADD3 wikiPageWikiLink Heteromer.
- ADD3 wikiPageWikiLink Hypertension.
- ADD3 wikiPageWikiLink N-terminus.
- ADD3 wikiPageWikiLink Omnipresence.
- ADD3 wikiPageWikiLink Phosphorylation_site.
- ADD3 wikiPageWikiLink Polymorphism_(biology).
- ADD3 wikiPageWikiLink Protease.
- ADD3 wikiPageWikiLink Protein.
- ADD3 wikiPageWikiLink Protein_dimer.
- ADD3 wikiPageWikiLink Protein_isoform.
- ADD3 wikiPageWikiLink Protein_kinase_C.
- ADD3 wikiPageWikiLink Protein_splicing.
- ADD3 wikiPageWikiLink Red_blood_cell.
- ADD3 wikiPageWikiLink Spectrin.
- ADD3 wikiPageWikiLinkText "ADD3".
- ADD3 requireManualInspection "no".
- ADD3 summaryText "Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is composed of two distinct domains. The amino-terminal region is protease-resistant and globular in shape, while the carboxy-terminal region is protease-sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.".
- ADD3 updateCitations "yes".
- ADD3 updatePage "yes".
- ADD3 updateProteinBox "yes".
- ADD3 updateSummary "yes".
- ADD3 wikiPageUsesTemplate Template:Cite_journal.
- ADD3 wikiPageUsesTemplate Template:Gene-10-stub.
- ADD3 wikiPageUsesTemplate Template:PBB.
- ADD3 wikiPageUsesTemplate Template:PBB_Controls.
- ADD3 wikiPageUsesTemplate Template:PBB_Further_reading.
- ADD3 wikiPageUsesTemplate Template:PBB_Summary.
- ADD3 wikiPageUsesTemplate Template:Refbegin.
- ADD3 wikiPageUsesTemplate Template:Refend.
- ADD3 wikiPageUsesTemplate Template:Reflist.
- ADD3 hypernym Protein.
- ADD3 type Biomolecule.
- ADD3 type Protein.
- ADD3 type Thing.
- ADD3 type Q206229.
- ADD3 type Q8054.
- ADD3 comment "Gamma-adducin is a protein that in humans is encoded by the ADD3 gene.Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues.".
- ADD3 label "ADD3".
- ADD3 sameAs Q17710014.
- ADD3 sameAs m.03h03dm.
- ADD3 sameAs Q17710014.
- ADD3 wasDerivedFrom ADD3?oldid=659774385.
- ADD3 isPrimaryTopicOf ADD3.