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- A-834,735 abstract "A-834,735 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors, with a Ki of 12nM at CB1 and 0.21nM at CB2. Replacing the aromatic 3-benzoyl or 3-naphthoyl group found in most indole derived cannabinoids, with the 3-tetramethylcyclopropylmethanone group of A-834,735 and related compounds, imparts significant selectivity for CB2, with most compounds from this group found to be highly selective CB2 agonists with little affinity for CB1. However low nanomolar CB1 binding affinity is retained with certain heterocyclic 1-position substituents such as (N-methylpiperidin-2-yl)methyl (cf. AM-1220, AM-1248), or the (tetrahydropyran-4-yl)methyl substituent of A-834,735, resulting in compounds that still show significant affinity and efficacy at both receptors despite being CB2 selective overall.".
- A-834,735 casNumber "895155-57-4".
- A-834,735 iupacName "{1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl}-(2,2,3,3-tetramethylcyclopropyl)methanone".
- A-834,735 pubchem "11544639".
- A-834,735 thumbnail A-834735_structure.png?width=300.
- A-834,735 wikiPageID "30404865".
- A-834,735 wikiPageLength "4513".
- A-834,735 wikiPageOutDegree "22".
- A-834,735 wikiPageRevisionID "683539147".
- A-834,735 wikiPageWikiLink A-796,260.
- A-834,735 wikiPageWikiLink AB-001.
- A-834,735 wikiPageWikiLink AB-005.
- A-834,735 wikiPageWikiLink AM-1220.
- A-834,735 wikiPageWikiLink AM-1248.
- A-834,735 wikiPageWikiLink Abbott_Laboratories.
- A-834,735 wikiPageWikiLink Agonist.
- A-834,735 wikiPageWikiLink Cannabinoid.
- A-834,735 wikiPageWikiLink Cannabinoid_receptor_type_1.
- A-834,735 wikiPageWikiLink Cannabinoid_receptor_type_2.
- A-834,735 wikiPageWikiLink Category:Cannabinoids.
- A-834,735 wikiPageWikiLink Category:Cyclopropanes.
- A-834,735 wikiPageWikiLink Category:Pyrans.
- A-834,735 wikiPageWikiLink Category:Tetramethylcyclopropanoylindoles.
- A-834,735 wikiPageWikiLink Dissociation_constant.
- A-834,735 wikiPageWikiLink FUB-144.
- A-834,735 wikiPageWikiLink Indole.
- A-834,735 wikiPageWikiLink JTE_7-31.
- A-834,735 wikiPageWikiLink Receptor_(biochemistry).
- A-834,735 wikiPageWikiLink UR-144.
- A-834,735 wikiPageWikiLink XLR-11_(drug).
- A-834,735 wikiPageWikiLinkText "A-834,735".
- A-834,735 c "22".
- A-834,735 casNumber "895155".
- A-834,735 chembl "271158".
- A-834,735 chemspiderid "9719418".
- A-834,735 h "29".
- A-834,735 iupacName "{1-[methyl]-1H-indol-3-yl}-methanone".
- A-834,735 n "1".
- A-834,735 o "2".
- A-834,735 pubchem "11544639".
- A-834,735 smiles "C4COCCC4Cnc2ccccc2c3CC1CC1C".
- A-834,735 stdinchi "1".
- A-834,735 stdinchikey "NQTMRZNYLIGQCF-UHFFFAOYSA-N".
- A-834,735 verifiedfields "changed".
- A-834,735 verifiedrevid "456505675".
- A-834,735 wikiPageUsesTemplate Template:Cannabinoid-stub.
- A-834,735 wikiPageUsesTemplate Template:Cannabinoids.
- A-834,735 wikiPageUsesTemplate Template:Cascite.
- A-834,735 wikiPageUsesTemplate Template:Chemspidercite.
- A-834,735 wikiPageUsesTemplate Template:Drugbankcite.
- A-834,735 wikiPageUsesTemplate Template:Drugbox.
- A-834,735 wikiPageUsesTemplate Template:Ebicite.
- A-834,735 wikiPageUsesTemplate Template:Reflist.
- A-834,735 wikiPageUsesTemplate Template:Stdinchicite.
- A-834,735 subject Category:Cannabinoids.
- A-834,735 subject Category:Cyclopropanes.
- A-834,735 subject Category:Pyrans.
- A-834,735 subject Category:Tetramethylcyclopropanoylindoles.
- A-834,735 hypernym Drug.
- A-834,735 type ChemicalSubstance.
- A-834,735 type Drug.
- A-834,735 type Cannabinoid.
- A-834,735 type Chemical.
- A-834,735 type Drug.
- A-834,735 type Heterocycle.
- A-834,735 type ChemicalObject.
- A-834,735 type Thing.
- A-834,735 type Q8386.
- A-834,735 comment "A-834,735 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors, with a Ki of 12nM at CB1 and 0.21nM at CB2.".
- A-834,735 label "A-834,735".
- A-834,735 sameAs Q4646879.
- A-834,735 sameAs m.0g5scsc.
- A-834,735 sameAs A-834,735.
- A-834,735 sameAs A-834,735.
- A-834,735 sameAs Q4646879.
- A-834,735 wasDerivedFrom A-834,735?oldid=683539147.
- A-834,735 depiction A-834735_structure.png.
- A-834,735 isPrimaryTopicOf A-834,735.