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- 5α-Androstane-3β,17β-diol abstract "5α-Androstane-3β,17β-diol, also called 3β-androstanediol, and often shortened to 3β-diol, is an endogenous steroid hormone. It is a 5α-reduced and 17β-hydroxylated metabolite of dehydroepiandrosterone (DHEA) as well as a 3β-hydroxylated metabolite of dihydrotestosterone (DHT). 3β-Diol is a selective, potent, high-affinity full agonist of the ERβ, and hence, an estrogen. It has higher affinity for this receptor than estradiol. In contrast to ERβ, 3β-diol does not bind to the androgen receptor (AR). 3β-Diol has been reported to also bind to ERα with low nanomolar affinity, with several-fold lower affinity relative to ERβ. Unlike its 3α-isomer, 3α-androstanediol (3α-diol), 3β-diol does not bind to the GABAA receptor.3β-Diol appears to be the endogenous ligand of ERβ in the prostate gland, and as a result of activation of the ERβ, 3β-diol has antiproliferative effects against prostate cancer cells. Through the ERβ, 3β-diol positively regulates oxytocin neurons and signaling in the paraventricular nucleus of hypothalamus (PVN), and has been found to have antidepressant, anxiolytic, cognitive-enhancing, and stress-relieving effects via this action. Androgens, including testosterone and dihydrotestosterone (DHT), are known to downregulate the hypothalamic-pituitary-adrenal axis, and this has been found to be due in part or full to their conversion into 3β-diol rather than to activation of the AR.A determination of the circulating levels of 3β-diol in humans found concentrations of 239 ± 76 pg/ml and 82 ± 45 pg/ml of the compound in normal male and female serum, respectively.An orally active synthetic analogue of 3β-diol, 17α-ethynyl-5α-androstane-3α,17β-diol (HE3235, Apoptone), was formerly under investigation for the treatment of prostate cancer and breast cancer.".
- 5α-Androstane-3β,17β-diol iupacName "(3β,5α,17β)-Androstane-3,17-diol".
- 5α-Androstane-3β,17β-diol thumbnail 3beta-Androstanediol.svg?width=300.
- 5α-Androstane-3β,17β-diol wikiPageID "35965214".
- 5α-Androstane-3β,17β-diol wikiPageLength "9911".
- 5α-Androstane-3β,17β-diol wikiPageOutDegree "49".
- 5α-Androstane-3β,17β-diol wikiPageRevisionID "700145187".
- 5α-Androstane-3β,17β-diol wikiPageWikiLink 17Beta_Hydroxysteroid_dehydrogenase.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink 17α-ethynyl-5α-androstane-3α,17β-diol.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink 3beta-Hydroxysteroid_dehydrogenase.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink 3α-Androstanediol.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink 5-alpha_reductase.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Agonist.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Androgen_receptor.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Antidepressant.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Anxiolytic.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Breast_cancer.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Category:Antidepressants.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Category:Anxiolytics.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Category:Estrogens.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Category:Selective_ERβ_agonists.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Category:Steroids.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Cell_(biology).
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Cell_signaling.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Concentration.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Cytostasis.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Dehydroepiandrosterone.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Dihydrotestosterone.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Endogeny_(biology).
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Epiandrosterone.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Estradiol.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Estrogen.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Estrogen_receptor_alpha.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Estrogen_receptor_beta.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Female.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink GABAA_receptor.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Human.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Hypothalamic–pituitary–adrenal_axis.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Ligand_(biochemistry).
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Male.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Metabolite.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Molar_concentration.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Neuron.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Nootropic.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Oxytocin.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Paraventricular_nucleus_of_hypothalamus.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Prostate.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Prostate_cancer.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Serum_(blood).
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Steroid_hormone.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Stress_management.
- 5α-Androstane-3β,17β-diol wikiPageWikiLink Testosterone.
- 5α-Androstane-3β,17β-diol wikiPageWikiLinkText "5α-Androstane-3β,17β-diol".
- 5α-Androstane-3β,17β-diol imagefile "3".
- 5α-Androstane-3β,17β-diol iupacname "-Androstane-3,17-diol".
- 5α-Androstane-3β,17β-diol othernames "3".
- 5α-Androstane-3β,17β-diol systematicname "-215".
- 5α-Androstane-3β,17β-diol wikiPageUsesTemplate Template:Chembox.
- 5α-Androstane-3β,17β-diol wikiPageUsesTemplate Template:Chembox_Hazards.
- 5α-Androstane-3β,17β-diol wikiPageUsesTemplate Template:Chembox_Identifiers.
- 5α-Androstane-3β,17β-diol wikiPageUsesTemplate Template:Chembox_Properties.
- 5α-Androstane-3β,17β-diol wikiPageUsesTemplate Template:Estrogenics.
- 5α-Androstane-3β,17β-diol wikiPageUsesTemplate Template:Reflist.
- 5α-Androstane-3β,17β-diol wikiPageUsesTemplate Template:Steroid_hormones.
- 5α-Androstane-3β,17β-diol subject Category:Antidepressants.
- 5α-Androstane-3β,17β-diol subject Category:Anxiolytics.
- 5α-Androstane-3β,17β-diol subject Category:Estrogens.
- 5α-Androstane-3β,17β-diol subject Category:Selective_ERβ_agonists.
- 5α-Androstane-3β,17β-diol subject Category:Steroids.
- 5α-Androstane-3β,17β-diol hypernym Hormone.
- 5α-Androstane-3β,17β-diol type ChemicalCompound.
- 5α-Androstane-3β,17β-diol type ChemicalSubstance.
- 5α-Androstane-3β,17β-diol type Lipid.
- 5α-Androstane-3β,17β-diol type Protein.
- 5α-Androstane-3β,17β-diol type Agonist.
- 5α-Androstane-3β,17β-diol type Androgen.
- 5α-Androstane-3β,17β-diol type Chemical.
- 5α-Androstane-3β,17β-diol type Estrogen.
- 5α-Androstane-3β,17β-diol type Hormone.
- 5α-Androstane-3β,17β-diol type Lipid.
- 5α-Androstane-3β,17β-diol type Redirect.
- 5α-Androstane-3β,17β-diol type Steroid.
- 5α-Androstane-3β,17β-diol type Terpene.
- 5α-Androstane-3β,17β-diol type ChemicalObject.
- 5α-Androstane-3β,17β-diol type Thing.
- 5α-Androstane-3β,17β-diol type Q11173.
- 5α-Androstane-3β,17β-diol comment "5α-Androstane-3β,17β-diol, also called 3β-androstanediol, and often shortened to 3β-diol, is an endogenous steroid hormone. It is a 5α-reduced and 17β-hydroxylated metabolite of dehydroepiandrosterone (DHEA) as well as a 3β-hydroxylated metabolite of dihydrotestosterone (DHT). 3β-Diol is a selective, potent, high-affinity full agonist of the ERβ, and hence, an estrogen. It has higher affinity for this receptor than estradiol.".
- 5α-Androstane-3β,17β-diol label "5α-Androstane-3β,17β-diol".
- 5α-Androstane-3β,17β-diol sameAs Q4641516.
- 5α-Androstane-3β,17β-diol sameAs ۳بتا-آندروستندیال.
- 5α-Androstane-3β,17β-diol sameAs m.04y9t_w.
- 5α-Androstane-3β,17β-diol sameAs 3β-Androstandiol.
- 5α-Androstane-3β,17β-diol sameAs 3β-Androstandiol.
- 5α-Androstane-3β,17β-diol sameAs Q4641516.
- 5α-Androstane-3β,17β-diol wasDerivedFrom 5α-Androstane-3β,17β-diol?oldid=700145187.
- 5α-Androstane-3β,17β-diol depiction 3beta-Androstanediol.svg.
- 5α-Androstane-3β,17β-diol isPrimaryTopicOf 5α-Androstane-3β,17β-diol.