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- 4,16-Androstadien-3β-ol abstract "4,16-Androstadien-3β-ol (developmental code name PH94B; tentative commercial name Aloradine or Aloradine IN) is a pherine which is under development by Pherin Pharmaceuticals, Inc. in a nasal spray formulation for the acute (p.r.n.) treatment of social anxiety disorder in women. It is also being investigated by Pherin Pharmaceuticals for the treatment of generalized anxiety disorder in women. As of 2015, it is in phase III clinical trials.The compound lacks affinity for steroid hormone receptors and has instead been found to directly activate isolated human vomeronasal receptor cells at nanomolar concentrations (EC50 = 200 nM).The pheromone androstenol has been found to act as a potent positive allosteric modulator of the GABAA receptor, and it has been proposed that this action may mediate its pheromone effects. It produces anxiolytic-like effects in animals. Androstadienol, androstadienone, and androstenone, all of which are also pheromones, have been found to be converted into androstenol, and as such, it may be responsible for their pheromone effects. As 4,16-androstadien-3β-ol is very closely related structurally to androstadienol (which is 5,16-androstadien-3β-ol), being a positional isomer of the steroid, the mechanism of action of 4,16-androstadien-3β-ol could similarly be potentiation of the GABAA receptor.".
- 4,16-Androstadien-3β-ol atcPrefix "None".
- 4,16-Androstadien-3β-ol casNumber "23062-06-8".
- 4,16-Androstadien-3β-ol drugbank "DB04968".
- 4,16-Androstadien-3β-ol iupacName "(3S,8S,9S,10R,13R,14S)-10,13-Dimethyl-2,3,6,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol".
- 4,16-Androstadien-3β-ol pubchem "9925482".
- 4,16-Androstadien-3β-ol thumbnail 4,16-Androstadien-3β-ol.svg?width=300.
- 4,16-Androstadien-3β-ol wikiPageExternalLink 800014893.
- 4,16-Androstadien-3β-ol wikiPageExternalLink products.html.
- 4,16-Androstadien-3β-ol wikiPageID "46784921".
- 4,16-Androstadien-3β-ol wikiPageLength "6654".
- 4,16-Androstadien-3β-ol wikiPageOutDegree "33".
- 4,16-Androstadien-3β-ol wikiPageRevisionID "700587254".
- 4,16-Androstadien-3β-ol wikiPageWikiLink Allosteric_modulator.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Androstadienol.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Androstadienone.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Androstenol.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Androstenone.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Androsterone.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Anxiolytic.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Category:Anxiolytics.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Category:Pherines.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Category:Steroids.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Cell_(biology).
- 4,16-Androstadien-3β-ol wikiPageWikiLink Clinical_trial.
- 4,16-Androstadien-3β-ol wikiPageWikiLink EC50.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Estratetraenol.
- 4,16-Androstadien-3β-ol wikiPageWikiLink GABAA_receptor.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Generalized_anxiety_disorder.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Insufflation_(medicine).
- 4,16-Androstadien-3β-ol wikiPageWikiLink Ligand_(biochemistry).
- 4,16-Androstadien-3β-ol wikiPageWikiLink Molar_concentration.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Nasal_spray.
- 4,16-Androstadien-3β-ol wikiPageWikiLink PH10_(drug).
- 4,16-Androstadien-3β-ol wikiPageWikiLink Phases_of_clinical_research.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Pherin_Pharmaceuticals,_Inc..
- 4,16-Androstadien-3β-ol wikiPageWikiLink Pherine.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Pregna-4,20-dien-3,6-dione.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Pro_re_nata.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Social_anxiety_disorder.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Steroid_hormone_receptor.
- 4,16-Androstadien-3β-ol wikiPageWikiLink Vomeronasal_receptor.
- 4,16-Androstadien-3β-ol wikiPageWikiLinkText "4,16-Androstadien-3β-ol".
- 4,16-Androstadien-3β-ol wikiPageWikiLinkText "PH94B".
- 4,16-Androstadien-3β-ol atcPrefix "None".
- 4,16-Androstadien-3β-ol c "19".
- 4,16-Androstadien-3β-ol casNumber "23062".
- 4,16-Androstadien-3β-ol chemspiderid "8101117".
- 4,16-Androstadien-3β-ol drugbank "DB04968".
- 4,16-Androstadien-3β-ol h "28".
- 4,16-Androstadien-3β-ol inchi "1".
- 4,16-Androstadien-3β-ol inchikey "NYVFCEPOUVGTNP-DYKIIFRCSA-N".
- 4,16-Androstadien-3β-ol iupacName "-1013".
- 4,16-Androstadien-3β-ol o "1".
- 4,16-Androstadien-3β-ol pubchem "9925482".
- 4,16-Androstadien-3β-ol routesOfAdministration Insufflation_(medicine).
- 4,16-Androstadien-3β-ol smiles "C[C@]12CC[C@H]3[C@H]CCC4=C[C@H]O".
- 4,16-Androstadien-3β-ol synonyms "3".
- 4,16-Androstadien-3β-ol width "200".
- 4,16-Androstadien-3β-ol wikiPageUsesTemplate Template:Anxiolytics.
- 4,16-Androstadien-3β-ol wikiPageUsesTemplate Template:Drugbox.
- 4,16-Androstadien-3β-ol wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- 4,16-Androstadien-3β-ol wikiPageUsesTemplate Template:Pheromones_and_pherines.
- 4,16-Androstadien-3β-ol wikiPageUsesTemplate Template:Reflist.
- 4,16-Androstadien-3β-ol wikiPageUsesTemplate Template:Steroid-stub.
- 4,16-Androstadien-3β-ol subject Category:Anxiolytics.
- 4,16-Androstadien-3β-ol subject Category:Pherines.
- 4,16-Androstadien-3β-ol subject Category:Steroids.
- 4,16-Androstadien-3β-ol hypernym Pherine.
- 4,16-Androstadien-3β-ol type ChemicalSubstance.
- 4,16-Androstadien-3β-ol type Drug.
- 4,16-Androstadien-3β-ol type ChemicalObject.
- 4,16-Androstadien-3β-ol type Thing.
- 4,16-Androstadien-3β-ol type Q8386.
- 4,16-Androstadien-3β-ol comment "4,16-Androstadien-3β-ol (developmental code name PH94B; tentative commercial name Aloradine or Aloradine IN) is a pherine which is under development by Pherin Pharmaceuticals, Inc. in a nasal spray formulation for the acute (p.r.n.) treatment of social anxiety disorder in women. It is also being investigated by Pherin Pharmaceuticals for the treatment of generalized anxiety disorder in women.".
- 4,16-Androstadien-3β-ol label "4,16-Androstadien-3β-ol".
- 4,16-Androstadien-3β-ol sameAs Q20707597.
- 4,16-Androstadien-3β-ol sameAs m.0139v42d.
- 4,16-Androstadien-3β-ol sameAs Q20707597.
- 4,16-Androstadien-3β-ol wasDerivedFrom 4,16-Androstadien-3β-ol?oldid=700587254.
- 4,16-Androstadien-3β-ol depiction 4,16-Androstadien-3β-ol.svg.
- 4,16-Androstadien-3β-ol isPrimaryTopicOf 4,16-Androstadien-3β-ol.