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- 27-Hydroxycholesterol abstract "27-Hydroxycholesterol (27-HC) is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.A link between high cholesterol and breast cancer has been identified, and it has been proposed that this is due to 27-HC production by CYP27A1. Because of its estrogenic action, 27-HC stimulates the growth of ER-positive breast cancer cells, and has been implicated in limiting the effectiveness of aromatase inhibitors in the treatment of breast cancer. As such, identified CYP27A1 inhibitors, including the marketed drugs anastrozole, fadrozole, bicalutamide, dexmedetomidine, ravuconazole, and posaconazole, have been proposed as potential adjuvant therapies in ER-positive breast cancer.".
- 27-Hydroxycholesterol iupacName "(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol".
- 27-Hydroxycholesterol thumbnail 27-Hydroxycholesterol.svg?width=300.
- 27-Hydroxycholesterol wikiPageID "41244917".
- 27-Hydroxycholesterol wikiPageLength "3253".
- 27-Hydroxycholesterol wikiPageOutDegree "26".
- 27-Hydroxycholesterol wikiPageRevisionID "679175729".
- 27-Hydroxycholesterol wikiPageWikiLink 20α,22R-Dihydroxycholesterol.
- 27-Hydroxycholesterol wikiPageWikiLink 22R-Hydroxycholesterol.
- 27-Hydroxycholesterol wikiPageWikiLink Adjuvant_therapy.
- 27-Hydroxycholesterol wikiPageWikiLink Agonist.
- 27-Hydroxycholesterol wikiPageWikiLink Agonist–antagonist.
- 27-Hydroxycholesterol wikiPageWikiLink Anastrozole.
- 27-Hydroxycholesterol wikiPageWikiLink Aromatase_inhibitor.
- 27-Hydroxycholesterol wikiPageWikiLink Bicalutamide.
- 27-Hydroxycholesterol wikiPageWikiLink Breast_cancer.
- 27-Hydroxycholesterol wikiPageWikiLink CYP27A1.
- 27-Hydroxycholesterol wikiPageWikiLink Category:Estrogens.
- 27-Hydroxycholesterol wikiPageWikiLink Category:Steroids.
- 27-Hydroxycholesterol wikiPageWikiLink Category:Sterols.
- 27-Hydroxycholesterol wikiPageWikiLink Cholesterol.
- 27-Hydroxycholesterol wikiPageWikiLink Dexmedetomidine.
- 27-Hydroxycholesterol wikiPageWikiLink Endogeny_(biology).
- 27-Hydroxycholesterol wikiPageWikiLink Enzyme.
- 27-Hydroxycholesterol wikiPageWikiLink Estrogen_receptor.
- 27-Hydroxycholesterol wikiPageWikiLink Fadrozole.
- 27-Hydroxycholesterol wikiPageWikiLink Function_(biology).
- 27-Hydroxycholesterol wikiPageWikiLink Liver_X_receptor.
- 27-Hydroxycholesterol wikiPageWikiLink Metabolite.
- 27-Hydroxycholesterol wikiPageWikiLink Oxysterol.
- 27-Hydroxycholesterol wikiPageWikiLink Posaconazole.
- 27-Hydroxycholesterol wikiPageWikiLink Ravuconazole.
- 27-Hydroxycholesterol wikiPageWikiLink Selective_estrogen_receptor_modulator.
- 27-Hydroxycholesterol wikiPageWikiLinkText "27-Hydroxycholesterol".
- 27-Hydroxycholesterol imagefile "27".
- 27-Hydroxycholesterol imagesize "200".
- 27-Hydroxycholesterol iupacname "-17".
- 27-Hydroxycholesterol systematicname "Cholest-5-ene-3-β,26-diol".
- 27-Hydroxycholesterol wikiPageUsesTemplate Template:Chembox.
- 27-Hydroxycholesterol wikiPageUsesTemplate Template:Chembox_Hazards.
- 27-Hydroxycholesterol wikiPageUsesTemplate Template:Chembox_Identifiers.
- 27-Hydroxycholesterol wikiPageUsesTemplate Template:Chembox_Properties.
- 27-Hydroxycholesterol wikiPageUsesTemplate Template:Estrogenics.
- 27-Hydroxycholesterol wikiPageUsesTemplate Template:Nuclear_receptor_ligands.
- 27-Hydroxycholesterol wikiPageUsesTemplate Template:Reflist.
- 27-Hydroxycholesterol wikiPageUsesTemplate Template:Steroid-stub.
- 27-Hydroxycholesterol wikiPageUsesTemplate Template:Steroid_hormones.
- 27-Hydroxycholesterol subject Category:Estrogens.
- 27-Hydroxycholesterol subject Category:Steroids.
- 27-Hydroxycholesterol subject Category:Sterols.
- 27-Hydroxycholesterol hypernym Oxysterol.
- 27-Hydroxycholesterol type ChemicalCompound.
- 27-Hydroxycholesterol type ChemicalSubstance.
- 27-Hydroxycholesterol type ChemicalObject.
- 27-Hydroxycholesterol type Thing.
- 27-Hydroxycholesterol type Q11173.
- 27-Hydroxycholesterol comment "27-Hydroxycholesterol (27-HC) is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR).".
- 27-Hydroxycholesterol label "27-Hydroxycholesterol".
- 27-Hydroxycholesterol sameAs Q15634124.
- 27-Hydroxycholesterol sameAs 27-ヒドロキシコレステロール.
- 27-Hydroxycholesterol sameAs m.0zgccd6.
- 27-Hydroxycholesterol sameAs Q15634124.
- 27-Hydroxycholesterol wasDerivedFrom 27-Hydroxycholesterol?oldid=679175729.
- 27-Hydroxycholesterol depiction 27-Hydroxycholesterol.svg.
- 27-Hydroxycholesterol isPrimaryTopicOf 27-Hydroxycholesterol.