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- 2-Methoxyestradiol abstract "2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem. It prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor.It also acts as a vasodilator.2ME2 is derived from estrogen, although it binds poorly to known estrogen receptors.It induces apoptosis in some cancer cell lines.It has undergone Phase 1 clinical trials against breast cancer.A phase II trial of 18 advanced ovarian cancer patients reported encouraging results in Oct 2007.Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Several studies have been conducted showing 2ME2 is a microtubule-inhibitor and effective against prostate cancer in rodents.The CAS name for 2ME2 is (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol.".
- 2-Methoxyestradiol casNumber "362-07-2".
- 2-Methoxyestradiol chEBI "28955".
- 2-Methoxyestradiol fdaUniiCode "6I2QW73SR5".
- 2-Methoxyestradiol iupacName "(8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol".
- 2-Methoxyestradiol pubchem "66414".
- 2-Methoxyestradiol thumbnail 2-Methoxyestradiol.svg?width=300.
- 2-Methoxyestradiol wikiPageExternalLink detail.go?type=chem&acc=C022830.
- 2-Methoxyestradiol wikiPageExternalLink dispprod.php?ItemId=78389.
- 2-Methoxyestradiol wikiPageID "1300633".
- 2-Methoxyestradiol wikiPageLength "5302".
- 2-Methoxyestradiol wikiPageOutDegree "19".
- 2-Methoxyestradiol wikiPageRevisionID "699036022".
- 2-Methoxyestradiol wikiPageWikiLink Angiogenesis.
- 2-Methoxyestradiol wikiPageWikiLink Angiogenesis_inhibitor.
- 2-Methoxyestradiol wikiPageWikiLink Apoptosis.
- 2-Methoxyestradiol wikiPageWikiLink Blood_vessel.
- 2-Methoxyestradiol wikiPageWikiLink Breast_cancer.
- 2-Methoxyestradiol wikiPageWikiLink Category:Steroids.
- 2-Methoxyestradiol wikiPageWikiLink Chemical_Abstracts_Service.
- 2-Methoxyestradiol wikiPageWikiLink Clinical_trial.
- 2-Methoxyestradiol wikiPageWikiLink Comparative_Toxicogenomics_Database.
- 2-Methoxyestradiol wikiPageWikiLink Drug_development.
- 2-Methoxyestradiol wikiPageWikiLink Estradiol.
- 2-Methoxyestradiol wikiPageWikiLink Estrogen.
- 2-Methoxyestradiol wikiPageWikiLink Inflammation.
- 2-Methoxyestradiol wikiPageWikiLink Neoplasm.
- 2-Methoxyestradiol wikiPageWikiLink Ovarian_cancer.
- 2-Methoxyestradiol wikiPageWikiLink Receptor_(biochemistry).
- 2-Methoxyestradiol wikiPageWikiLink Rheumatoid_arthritis.
- 2-Methoxyestradiol wikiPageWikiLink Vasodilation.
- 2-Methoxyestradiol wikiPageWikiLinkText "2-Methoxyestradiol".
- 2-Methoxyestradiol c "19".
- 2-Methoxyestradiol casNumber "0362-07-02".
- 2-Methoxyestradiol chebi "28955".
- 2-Methoxyestradiol chembl "299613".
- 2-Methoxyestradiol chemspiderid "59788".
- 2-Methoxyestradiol h "26".
- 2-Methoxyestradiol inchi "1".
- 2-Methoxyestradiol inchikey "CQOQDQWUFQDJMK-SSTWWWIQBL".
- 2-Methoxyestradiol iupacName "-2".
- 2-Methoxyestradiol molecularWeight "302.408".
- 2-Methoxyestradiol o "3".
- 2-Methoxyestradiol pubchem "66414".
- 2-Methoxyestradiol smiles "Oc1cc3c[C@H]2CC[C@@]4C".
- 2-Methoxyestradiol stdinchi "1".
- 2-Methoxyestradiol stdinchikey "CQOQDQWUFQDJMK-SSTWWWIQSA-N".
- 2-Methoxyestradiol unii "6".
- 2-Methoxyestradiol verifiedfields "changed".
- 2-Methoxyestradiol verifiedrevid "477213877".
- 2-Methoxyestradiol wikiPageUsesTemplate Template:Cascite.
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- 2-Methoxyestradiol wikiPageUsesTemplate Template:Ebicite.
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- 2-Methoxyestradiol subject Category:Steroids.
- 2-Methoxyestradiol hypernym Metabolite.
- 2-Methoxyestradiol type ChemicalCompound.
- 2-Methoxyestradiol type ChemicalSubstance.
- 2-Methoxyestradiol type Drug.
- 2-Methoxyestradiol type Lipid.
- 2-Methoxyestradiol type Chemical.
- 2-Methoxyestradiol type Lipid.
- 2-Methoxyestradiol type Redirect.
- 2-Methoxyestradiol type Steroid.
- 2-Methoxyestradiol type Terpene.
- 2-Methoxyestradiol type ChemicalObject.
- 2-Methoxyestradiol type Thing.
- 2-Methoxyestradiol type Q8386.
- 2-Methoxyestradiol comment "2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem.".
- 2-Methoxyestradiol label "2-Methoxyestradiol".
- 2-Methoxyestradiol sameAs Q4596897.
- 2-Methoxyestradiol sameAs m.04r33q.
- 2-Methoxyestradiol sameAs 2-Metoksiestradiol.
- 2-Methoxyestradiol sameAs 2-Metoksiestradiol.
- 2-Methoxyestradiol sameAs Q4596897.
- 2-Methoxyestradiol wasDerivedFrom 2-Methoxyestradiol?oldid=699036022.
- 2-Methoxyestradiol depiction 2-Methoxyestradiol.svg.
- 2-Methoxyestradiol isPrimaryTopicOf 2-Methoxyestradiol.