Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/18-Methoxycoronaridine> ?p ?o }
- 18-Methoxycoronaridine abstract "(–)-18-Methoxycoronaridine (18-MC) is a derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley D. Glick from the Albany Medical College and the chemist Martin E. Kuehne from the University of Vermont. In animal studies it has proved to be effective at reducing self-administration of morphine, cocaine, methamphetamine, nicotine and sucrose.18-MC is a α3β4 nicotinic antagonist and, in contrast to ibogaine, has no affinity at the α4β2 subtype nor at NMDA-channels nor at the serotonin transporter, and has significantly reduced affinity for sodium channels and for the σ receptor, but retains modest affinity for μ-opioid receptors where it acts as an antagonist, and κ-opioid receptors. The sites of action in the brain include the medial habenula, interpeduncular nucleus, dorsolateral tegmentum and basolateral amygdala. It has also been shown to produce anorectic effects in obese rats, most likely due to the same actions on the reward system which underlie its anti-addictive effects against drug addiction.18-MC is in the early stages of human testing by Savant HWP. In 2002 the research team started trying to raise funds for human trials, but were unable to secure the estimated $5 million needed. In January 2010, Obiter Research, a chemical manufacturer in Champaign, Illinois, signed a patent license with Albany Medical College and the University of Vermont allowing them the right to synthesize and market 18-MC and other congeners. National Institute on Drug Abuse gave a $6.5 million grant in 2012 to California-based drug developer company Savant HWP for the human trials.A number of derivatives of 18-MC have also been developed, with several of them being superior to 18-MC itself, the methoxyethyl congener ME-18-MC being more potent than 18-MC but with similar efficacy, and the methylamino analogue 18-MAC being more effective than 18-MC but with around the same potency. These compounds were also found to act as selective α3β4 nicotinic acetylcholine antagonists, with little or no effect on NMDA receptors.500px".
- 18-Methoxycoronaridine casNumber "308123-60-6".
- 18-Methoxycoronaridine iupacName "(–)-18-methoxycoronaridine".
- 18-Methoxycoronaridine pubchem "10248465".
- 18-Methoxycoronaridine thumbnail 18-Methoxycoronaridine.svg?width=300.
- 18-Methoxycoronaridine wikiPageID "4573749".
- 18-Methoxycoronaridine wikiPageLength "10101".
- 18-Methoxycoronaridine wikiPageOutDegree "37".
- 18-Methoxycoronaridine wikiPageRevisionID "707163563".
- 18-Methoxycoronaridine wikiPageWikiLink 18-Methylaminocoronaridine.
- 18-Methoxycoronaridine wikiPageWikiLink 2-Methoxyethyl-18-methoxycoronaridinate.
- 18-Methoxycoronaridine wikiPageWikiLink Albany_Medical_College.
- 18-Methoxycoronaridine wikiPageWikiLink Alpha-4_beta-2_nicotinic_receptor.
- 18-Methoxycoronaridine wikiPageWikiLink Anorectic.
- 18-Methoxycoronaridine wikiPageWikiLink Basolateral_amygdala.
- 18-Methoxycoronaridine wikiPageWikiLink Category:Drug_rehabilitation.
- 18-Methoxycoronaridine wikiPageWikiLink Category:Iboga.
- 18-Methoxycoronaridine wikiPageWikiLink Category:Kappa_agonists.
- 18-Methoxycoronaridine wikiPageWikiLink Category:Nicotinic_antagonists.
- 18-Methoxycoronaridine wikiPageWikiLink Category:Opioid_antagonists.
- 18-Methoxycoronaridine wikiPageWikiLink Cocaine.
- 18-Methoxycoronaridine wikiPageWikiLink Coronaridine.
- 18-Methoxycoronaridine wikiPageWikiLink Dorsolateral_tegmentum.
- 18-Methoxycoronaridine wikiPageWikiLink Ganglion_type_nicotinic_receptor.
- 18-Methoxycoronaridine wikiPageWikiLink Habenula.
- 18-Methoxycoronaridine wikiPageWikiLink Ibogaine.
- 18-Methoxycoronaridine wikiPageWikiLink Interpeduncular_nucleus.
- 18-Methoxycoronaridine wikiPageWikiLink Martin_E._Kuehne.
- 18-Methoxycoronaridine wikiPageWikiLink Methamphetamine.
- 18-Methoxycoronaridine wikiPageWikiLink Morphine.
- 18-Methoxycoronaridine wikiPageWikiLink N-Methyl-D-aspartic_acid.
- 18-Methoxycoronaridine wikiPageWikiLink National_Institute_on_Drug_Abuse.
- 18-Methoxycoronaridine wikiPageWikiLink Nicotine.
- 18-Methoxycoronaridine wikiPageWikiLink Nicotinic_acetylcholine_receptor.
- 18-Methoxycoronaridine wikiPageWikiLink Noribogaine.
- 18-Methoxycoronaridine wikiPageWikiLink Serotonin_transporter.
- 18-Methoxycoronaridine wikiPageWikiLink Sigma_receptor.
- 18-Methoxycoronaridine wikiPageWikiLink Sodium_channel.
- 18-Methoxycoronaridine wikiPageWikiLink Stanley_D._Glick.
- 18-Methoxycoronaridine wikiPageWikiLink Sucrose.
- 18-Methoxycoronaridine wikiPageWikiLink University_of_Vermont.
- 18-Methoxycoronaridine wikiPageWikiLink Voacangine.
- 18-Methoxycoronaridine wikiPageWikiLink Κ-opioid_receptor.
- 18-Methoxycoronaridine wikiPageWikiLink Μ-opioid_receptor.
- 18-Methoxycoronaridine wikiPageWikiLink File:Iboga_alkaloids.png.
- 18-Methoxycoronaridine wikiPageWikiLinkText "18-Methoxycoronaridine".
- 18-Methoxycoronaridine c "22".
- 18-Methoxycoronaridine casNumber "308123".
- 18-Methoxycoronaridine chemspiderid "8423952".
- 18-Methoxycoronaridine h "28".
- 18-Methoxycoronaridine inchi "1".
- 18-Methoxycoronaridine inchikey "DTJQBBHYRQYDEG-YHIIEBRDBA".
- 18-Methoxycoronaridine iupacName "-18".
- 18-Methoxycoronaridine legalStatus "US IND filed 2/9/2014".
- 18-Methoxycoronaridine molecularWeight "368.47".
- 18-Methoxycoronaridine n "2".
- 18-Methoxycoronaridine o "3".
- 18-Methoxycoronaridine pubchem "10248465".
- 18-Methoxycoronaridine routesOfAdministration "oral".
- 18-Methoxycoronaridine smiles "O=C[C@@]43c2nc1ccccc1c2CCN5C3[C@H]CCOC".
- 18-Methoxycoronaridine stdinchi "1".
- 18-Methoxycoronaridine stdinchikey "DTJQBBHYRQYDEG-YHIIEBRDSA-N".
- 18-Methoxycoronaridine verifiedfields "changed".
- 18-Methoxycoronaridine verifiedrevid "477209336".
- 18-Methoxycoronaridine width "180".
- 18-Methoxycoronaridine wikiPageUsesTemplate Template:Cascite.
- 18-Methoxycoronaridine wikiPageUsesTemplate Template:Chemspidercite.
- 18-Methoxycoronaridine wikiPageUsesTemplate Template:Cholinergics.
- 18-Methoxycoronaridine wikiPageUsesTemplate Template:Cite_journal.
- 18-Methoxycoronaridine wikiPageUsesTemplate Template:Drugbox.
- 18-Methoxycoronaridine wikiPageUsesTemplate Template:Opioidergics.
- 18-Methoxycoronaridine wikiPageUsesTemplate Template:Reflist.
- 18-Methoxycoronaridine wikiPageUsesTemplate Template:Stdinchicite.
- 18-Methoxycoronaridine subject Category:Drug_rehabilitation.
- 18-Methoxycoronaridine subject Category:Iboga.
- 18-Methoxycoronaridine subject Category:Kappa_agonists.
- 18-Methoxycoronaridine subject Category:Nicotinic_antagonists.
- 18-Methoxycoronaridine subject Category:Opioid_antagonists.
- 18-Methoxycoronaridine hypernym Derivative.
- 18-Methoxycoronaridine type Biomolecule.
- 18-Methoxycoronaridine type ChemicalSubstance.
- 18-Methoxycoronaridine type Drug.
- 18-Methoxycoronaridine type Group.
- 18-Methoxycoronaridine type Agonist.
- 18-Methoxycoronaridine type Alkaloid.
- 18-Methoxycoronaridine type Antagonist.
- 18-Methoxycoronaridine type Biomolecule.
- 18-Methoxycoronaridine type Chemical.
- 18-Methoxycoronaridine type Disorder.
- 18-Methoxycoronaridine type Dissociative.
- 18-Methoxycoronaridine type Entheogen.
- 18-Methoxycoronaridine type Group.
- 18-Methoxycoronaridine type Opioid.
- 18-Methoxycoronaridine type Redirect.
- 18-Methoxycoronaridine type ChemicalObject.
- 18-Methoxycoronaridine type Thing.
- 18-Methoxycoronaridine type Q8386.
- 18-Methoxycoronaridine comment "(–)-18-Methoxycoronaridine (18-MC) is a derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley D. Glick from the Albany Medical College and the chemist Martin E. Kuehne from the University of Vermont.".
- 18-Methoxycoronaridine label "18-Methoxycoronaridine".
- 18-Methoxycoronaridine sameAs Q200107.