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- 12-O-Tetradecanoylphorbol-13-acetate abstract "12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA), is a diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol. TPA is a small molecule drug.In ROS biology, superoxide, but not hydrogen peroxide, hydroxyl radical, peroxynitrite, was identified as the major ROS species induced by TPA/PMA but not by ionomycin in mouse macrophages. Thus, TPA/PMA has been routinely used as an inducer for endogenous superoxide production.TPA is also being studied as a drug in the treatment of hematologic cancerTPA has a specific use in cancer diagnostics as a B-cell specific mitogen in cytogenetic testing. To view the chromosomes, a cytogenetic test requires dividing cells. TPA is used to stimulate division of B-cells during cytogenetic diagnosis of B-cell cancers such as chronic lymphocytic leukemia.TPA is also commonly used together with ionomycin to stimulate T-cell activation, proliferation, and cytokine production, and is used in protocols for intracellular staining of these cytokines.TPA was first found in the croton plant, a shrub found in Southeast Asia, exposure to which provokes a poison ivy-like rash. It underwent a phase 1 clinical trial.".
- 12-O-Tetradecanoylphorbol-13-acetate iupacName "(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl myristate".
- 12-O-Tetradecanoylphorbol-13-acetate thumbnail 12-O-Tetradecanoylphorbol-13-acetate.svg?width=300.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageID "1300599".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageLength "5695".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageOutDegree "29".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageRevisionID "692362549".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink B-cell_chronic_lymphocytic_leukemia.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Cancer.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Category:Acetate_esters.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Category:Carcinogens.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Category:Cyclopropanes.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Category:Diterpenes.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Clinical_trial.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Croton_(plant).
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Cytogenetics.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Diglyceride.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Enzyme.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Hematology.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Hydrogen_peroxide.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Hydroxyl_radical.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Ionomycin.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Mitogen.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Peroxynitrite.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Pharmaceutical_drug.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Phorbol.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Protein_kinase_C.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Reactive_oxygen_species.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Signal_transduction.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Small_molecule.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Superoxide.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Toxicodendron_radicans.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLink Tumor_promotion.
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLinkText "12-''O''-Tetradecanoylphorbol-13-acetate".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLinkText "12-''O''-tetradecanoylphorbol-13-acetate".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLinkText "12-O-Tetradecanoylphorbol-13-acetate".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLinkText "PMA".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLinkText "TPA".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLinkText "phorbol 12-myristate 13-acetate".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLinkText "phorbol ester".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageWikiLinkText "phorbol myristate acetate".
- 12-O-Tetradecanoylphorbol-13-acetate imagefile "12".
- 12-O-Tetradecanoylphorbol-13-acetate imagename "TPA".
- 12-O-Tetradecanoylphorbol-13-acetate imagesize "300".
- 12-O-Tetradecanoylphorbol-13-acetate iupacname "-9".
- 12-O-Tetradecanoylphorbol-13-acetate name "12".
- 12-O-Tetradecanoylphorbol-13-acetate othernames "TPA, PMA, Phorbol myristate acetate,".
- 12-O-Tetradecanoylphorbol-13-acetate othernames "Tetradecanoylphorbol acetate.".
- 12-O-Tetradecanoylphorbol-13-acetate verifiedfields "changed".
- 12-O-Tetradecanoylphorbol-13-acetate verifiedrevid "477208864".
- 12-O-Tetradecanoylphorbol-13-acetate watchedfields "changed".
- 12-O-Tetradecanoylphorbol-13-acetate wikiPageUsesTemplate Template:Cascite.
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- 12-O-Tetradecanoylphorbol-13-acetate subject Category:Acetate_esters.
- 12-O-Tetradecanoylphorbol-13-acetate subject Category:Carcinogens.
- 12-O-Tetradecanoylphorbol-13-acetate subject Category:Cyclopropanes.
- 12-O-Tetradecanoylphorbol-13-acetate subject Category:Diterpenes.
- 12-O-Tetradecanoylphorbol-13-acetate hypernym Diester.
- 12-O-Tetradecanoylphorbol-13-acetate type ChemicalCompound.
- 12-O-Tetradecanoylphorbol-13-acetate type ChemicalSubstance.
- 12-O-Tetradecanoylphorbol-13-acetate type Chemical.
- 12-O-Tetradecanoylphorbol-13-acetate type Diterpene.
- 12-O-Tetradecanoylphorbol-13-acetate type Ester.
- 12-O-Tetradecanoylphorbol-13-acetate type Redirect.
- 12-O-Tetradecanoylphorbol-13-acetate type Terpene.
- 12-O-Tetradecanoylphorbol-13-acetate type ChemicalObject.
- 12-O-Tetradecanoylphorbol-13-acetate type Thing.
- 12-O-Tetradecanoylphorbol-13-acetate type Q11173.
- 12-O-Tetradecanoylphorbol-13-acetate comment "12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA), is a diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol.".
- 12-O-Tetradecanoylphorbol-13-acetate label "12-O-Tetradecanoylphorbol-13-acetate".
- 12-O-Tetradecanoylphorbol-13-acetate sameAs Q416716.
- 12-O-Tetradecanoylphorbol-13-acetate sameAs Phorbol-12-myristat-13-acetat.
- 12-O-Tetradecanoylphorbol-13-acetate sameAs ۱۲-او-تترادکانویلفوربویل-۱۳-استات.
- 12-O-Tetradecanoylphorbol-13-acetate sameAs 12-O-テトラデカノイルホルボール_13-アセタート.
- 12-O-Tetradecanoylphorbol-13-acetate sameAs m.04r2_v.
- 12-O-Tetradecanoylphorbol-13-acetate sameAs 12-O-Tetradekanoilforbol-13-acetat.
- 12-O-Tetradecanoylphorbol-13-acetate sameAs 12-O-Tetradekanoilforbol-13-acetat.
- 12-O-Tetradecanoylphorbol-13-acetate sameAs Q416716.
- 12-O-Tetradecanoylphorbol-13-acetate sameAs 佛波醇-12-十四烷酰-13-乙酸酯.
- 12-O-Tetradecanoylphorbol-13-acetate wasDerivedFrom 12-O-Tetradecanoylphorbol-13-acetate?oldid=692362549.
- 12-O-Tetradecanoylphorbol-13-acetate depiction 12-O-Tetradecanoylphorbol-13-acetate.svg.
- 12-O-Tetradecanoylphorbol-13-acetate isPrimaryTopicOf 12-O-Tetradecanoylphorbol-13-acetate.
- 12-O-Tetradecanoylphorbol-13-acetate name "12-O-Tetradecanoylphorbol-13-acetate".