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- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate abstract "(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP or HMB-PP) is an intermediate of the MEP pathway (non-mevalonate pathway) of isoprenoid biosynthesis. The enzyme HMB-PP synthase (GcpE, IspG) catalyzes the conversion of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) into HMB-PP. HMB-PP is then converted further to isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) by HMB-PP reductase (LytB, IspH).HMB-PP is an essential metabolite in most pathogenic bacteria including Mycobacterium tuberculosis as well as in malaria parasites, but is absent from the human host.HMB-PP is the physiological activator (\"phosphoantigen\") for human Vγ9/Vδ2 T cells, the major γδ T cell population in peripheral blood. With a bioactivity of 0.1 nM it is 10,000-10,000,000 times more potent than any other natural compound, such as IPP or alkyl amines. HMB-PP functions in this capacity by binding the B30.2 domain of BTN3A1.".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate iupacName "(E)-4-hydroxy-3-methylbut-2-enoxy-oxidophosphoryl phosphate".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate thumbnail HMB-PP.PNG?width=300.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageID "8399736".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageLength "4686".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageOutDegree "17".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageRevisionID "696163233".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink 2-C-Methyl-D-erythritol-2,4-cyclopyrophosphate.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink 4-Hydroxy-3-methylbut-2-enyl_diphosphate_reductase.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink 4-hydroxy-3-methylbut-2-en-1-yl_diphosphate_synthase.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Butyrophilin,_subfamily_3,_member_A1.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Category:Biomolecules.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Category:Hemiterpenes.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Category:Metabolism.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Category:Organophosphates.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Dimethylallyl_pyrophosphate.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Gamma_delta_T_cell.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Isopentenyl_pyrophosphate.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Malaria.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Mycobacterium_tuberculosis.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Non-mevalonate_pathway.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLink Non-peptidic_antigen.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLinkText "(''E'')-4-hydroxy-3-methyl-but-2-enyl pyrophosphate".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLinkText "(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageWikiLinkText "(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate imagefile "HMB-PP.PNG".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate imagefile "HMBPP-3D-balls.png".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate imagename "Ball-and-stick model, shown here as a 3- ion".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate imagename "Chemical structure of HMB-PP".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate imagesize "190".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate imagesize "240".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate iupacname "-4".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate name "-4".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate othernames "-4".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate othernames "HDMAPP".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate othernames "HMBDP".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate verifiedrevid "477199926".
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- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wikiPageUsesTemplate Template:MeshName.
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- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate subject Category:Biomolecules.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate subject Category:Hemiterpenes.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate subject Category:Metabolism.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate subject Category:Organophosphates.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Biomolecule.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type ChemicalCompound.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type ChemicalSubstance.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Biomolecule.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Chemical.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Ester.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Organophosphate.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Organophosphoru.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Process.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Product.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Redirect.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Terpene.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Organophosphate.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Organophosphoru.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type ChemicalObject.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Thing.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate type Q11173.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate comment "(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP or HMB-PP) is an intermediate of the MEP pathway (non-mevalonate pathway) of isoprenoid biosynthesis. The enzyme HMB-PP synthase (GcpE, IspG) catalyzes the conversion of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) into HMB-PP.".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate label "(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate".
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate sameAs Q2708007.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate sameAs (ایی)_-۴-هیدروکسی-۳-متیل-بوت-۲-انیل_پیروفسفات.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate sameAs (E)-4-hydroksi-3-metyylibut-2-enyylipyrofosfaatti.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate sameAs (E)-4-Hydroxy-3-méthyl-but-2-ényl-pyrophosphate.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate sameAs (E)-4-ヒドロキシ-3-メチル-2-ブテニル二リン酸.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate sameAs m.02724nx.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate sameAs (E)-4-Hidroksi-3-metil-but-2-enil_pirofosfat.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate sameAs (E)-4-Hidroksi-3-metil-but-2-enil_pirofosfat.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate sameAs Q2708007.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate wasDerivedFrom (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate?oldid=696163233.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate depiction HMB-PP.PNG.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate isPrimaryTopicOf (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate.
- (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate name "(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate".
