Matches in DBpedia 2016-04 for { ?s ?p "Upjohn dihydroxylation is an organic reaction converting an alkene to a cis vicinal diol, and was developed by V. VanRheenen, R. C. Kelly and D. Y. Cha of the Upjohn Company, USA in 1976. It is a catalytic system using N-methylmorpholine N-oxide (NMO) as stoichiometric re-oxidant for the Osmium tetroxide, and is superior to previous catalytic methods. Prior to this method, use of stoichiometric amounts of the toxic and expensive osmium tetroxide was often necessary. The Upjohn dihydroxylation is still often used for the formation of cis-vicinal diols, however it can be slow and is prone to over-oxidation of the substrate to the vicinal di-ketone. One of the peculiarities of the dihydroxylation of olefins is that the standard \"racemic\" method (the Upjohn dihydroxyation) is slower and often lower yielding than the asymmetric method (the Sharpless asymmetric dihydroxylation)."@en }
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- Upjohn_dihydroxylation abstract "Upjohn dihydroxylation is an organic reaction converting an alkene to a cis vicinal diol, and was developed by V. VanRheenen, R. C. Kelly and D. Y. Cha of the Upjohn Company, USA in 1976. It is a catalytic system using N-methylmorpholine N-oxide (NMO) as stoichiometric re-oxidant for the Osmium tetroxide, and is superior to previous catalytic methods. Prior to this method, use of stoichiometric amounts of the toxic and expensive osmium tetroxide was often necessary. The Upjohn dihydroxylation is still often used for the formation of cis-vicinal diols, however it can be slow and is prone to over-oxidation of the substrate to the vicinal di-ketone. One of the peculiarities of the dihydroxylation of olefins is that the standard \"racemic\" method (the Upjohn dihydroxyation) is slower and often lower yielding than the asymmetric method (the Sharpless asymmetric dihydroxylation).".