Matches in DBpedia 2016-04 for { ?s ?p "Smoothened agonist (SAG) was one of the first small-molecule agonists developed for the protein Smoothened, a key part of the hedgehog signaling pathway, which is involved in brain development as well as having a number of other functions in the body. Smoothened agonist has been shown to aid proliferation and survival of developing neurons, and prevent drug-induced brain injury. When injected into the cerebellum of newborn mice with an induced Down's syndrome-like condition, Smoothened agonist was able to stimulate normal cerebellum development, resulting in significant behavioural improvement once the mice had grown to adulthood."@en }
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- Smoothened_agonist abstract "Smoothened agonist (SAG) was one of the first small-molecule agonists developed for the protein Smoothened, a key part of the hedgehog signaling pathway, which is involved in brain development as well as having a number of other functions in the body. Smoothened agonist has been shown to aid proliferation and survival of developing neurons, and prevent drug-induced brain injury. When injected into the cerebellum of newborn mice with an induced Down's syndrome-like condition, Smoothened agonist was able to stimulate normal cerebellum development, resulting in significant behavioural improvement once the mice had grown to adulthood.".
- Q15410188 abstract "Smoothened agonist (SAG) was one of the first small-molecule agonists developed for the protein Smoothened, a key part of the hedgehog signaling pathway, which is involved in brain development as well as having a number of other functions in the body. Smoothened agonist has been shown to aid proliferation and survival of developing neurons, and prevent drug-induced brain injury. When injected into the cerebellum of newborn mice with an induced Down's syndrome-like condition, Smoothened agonist was able to stimulate normal cerebellum development, resulting in significant behavioural improvement once the mice had grown to adulthood.".